GPER1相关文献与解析，生知库 | 链接生命科学的每一步

Pérez-Escudero, Natalia; Cabas, Isabel; Corbalán-Vélez, Raúl; Martínez-Menchón, Teresa; Ferri, Belén; Cayuela, María L; García-Moreno, Diana; García-Ayala, Alfonsa; Mulero, Victoriano

炎症

炎症/感染

PER1

GPER1 as a therapeutic target in MASLD: evidence for steatosis attenuation by agonist G1 in preclinical models.

GPER1 作为 MASLD 的治疗靶点：临床前模型中激动剂 G1 可减轻脂肪变性的证据。

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2026.1764287

Correction: AOH induces oxidative stress and DNA damage in ovarian cancer cells via modulation of GPER1 and HIF1α/PI3K/CLDNs signaling pathway

更正：AOH通过调节GPER1和HIF1α/PI3K/CLDNs信号通路诱导卵巢癌细胞氧化应激和DNA损伤

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-36730-9

Kozieł-Leszczyńska, Marta Justyna; Habrowska-Górczyńska, Dominika Ewa; Leszczyński, Kacper Piotr; Urbanek, Kinga Anna; Piastowska-Ciesielska, Agnieszka Wanda; Kowalska, Karolina

N-(2-Hydroxyphenyl)-2-propylpentanamide Modulates HDAC1 and GPER1 Expression in a Rodent Model of Triple-Negative Breast Cancer

N-(2-羟基苯基)-2-丙基戊酰胺在三阴性乳腺癌啮齿动物模型中调节HDAC1和GPER1的表达

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines14020322

Ramírez-Farías, Cynthia; Ventura-Juárez, Javier; Calvillo-Robledo, Argelia; Ávila-Blanco, Manuel Enrique; González-Blas, Daniel; Correa-Basurto, José; Quintanar Stephano, Andrés

GPER1 activation regulates renal purinergic P2Y(2) receptor natriuretic pathway

GPER1激活调节肾脏嘌呤能P2Y(2)受体利钠通路

期刊:American Journal of Physiology-Regulatory Integrative and Comparative Physiology

影响因子:2.3

doi:10.1152/ajpregu.00123.2025

Kulthinee, Supaporn; Nasci, Victoria L; Pollock, David M; Gohar, Eman Y

Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.

GPER1 的过表达通过激活 cAMP 通路抑制食管癌的生长。

期刊:European Journal of Histochemistry

影响因子:2.1

doi:10.4081/ejh.2026.4422

Yin Hongmei, Han Xiumei, Zhang Qun, Li Duojie, Wang Fan

AOH induces oxidative stress and DNA damage in ovarian cancer cells via modulation of GPER1 and HIF1α/PI3K/CLDNs signaling pathway

AOH通过调节GPER1和HIF1α/PI3K/CLDNs信号通路诱导卵巢癌细胞氧化应激和DNA损伤

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-26042-9

Kozieł-Leszczyńska, Marta Justyna; Habrowska-Górczyńska, Dominika Ewa; Leszczyński, Kacper Piotr; Urbanek, Kinga Anna; Piastowska-Ciesielska, Agnieszka Wanda; Kowalska, Karolina

Î²-estradiol alleviates hypoxic-ischemic brain damage in neonatal rats through the GPER1-mediated AKT/NF-ÎºB signaling pathway.

β-雌二醇通过GPER1介导的AKT/NF-κB信号通路减轻新生大鼠的缺氧缺血性脑损伤。

期刊:Archives of Medical Science

影响因子:3.3

doi:10.5114/aoms/192051

Zhang Guangyun, Yuan Dawei, Lv Tiegang, Li Huafeng, Zhang Yanli, Ding Yong, Cui Juan, Li Min, Yu Jing, Chen Jing, Xu Xiangping

Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms

精神分裂症中基于性别的雌激素受体调节：以男性为中心的ERβ/GPER1框架治疗认知和阴性症状

期刊:Frontiers in Psychiatry

影响因子:3.2

doi:10.3389/fpsyt.2025.1714569

Attenuation of Hypertension and protection of vascular inflammation in hyperaldosteronism: GPER1 as potential therapeutic candidate when MR antagonist is less satisfying?

GPER1能否作为治疗醛固酮增多症的潜在候选药物，以减轻高血压并保护血管免受炎症影响？当盐皮质激素受体拮抗剂疗效不佳时，GPER1是否可作为潜在的治疗靶点？

期刊:Endocrine

影响因子:2.9

doi:10.1007/s12020-024-04106-6

Lai, Yulian; Tang, Ziwei; Du, Zhipeng; Zeng, Qinglian; Xia, Yu; Chen, Shangbin; Li, Xun; Cheng, Qingfeng; Mei, Mei; He, Wenwen

GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation

GPER1通过抑制角质形成细胞增殖来减轻皮肤炎症。

GPER1 as a therapeutic target in MASLD: evidence for steatosis attenuation by agonist G1 in preclinical models.

GPER1 作为 MASLD 的治疗靶点：临床前模型中激动剂 G1 可减轻脂肪变性的证据。

Correction: AOH induces oxidative stress and DNA damage in ovarian cancer cells via modulation of GPER1 and HIF1α/PI3K/CLDNs signaling pathway

更正：AOH通过调节GPER1和HIF1α/PI3K/CLDNs信号通路诱导卵巢癌细胞氧化应激和DNA损伤

N-(2-Hydroxyphenyl)-2-propylpentanamide Modulates HDAC1 and GPER1 Expression in a Rodent Model of Triple-Negative Breast Cancer

N-(2-羟基苯基)-2-丙基戊酰胺在三阴性乳腺癌啮齿动物模型中调节HDAC1和GPER1的表达

GPER1 activation regulates renal purinergic P2Y(2) receptor natriuretic pathway

GPER1激活调节肾脏嘌呤能P2Y(2)受体利钠通路

Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.

GPER1 的过表达通过激活 cAMP 通路抑制食管癌的生长。

AOH induces oxidative stress and DNA damage in ovarian cancer cells via modulation of GPER1 and HIF1α/PI3K/CLDNs signaling pathway

AOH通过调节GPER1和HIF1α/PI3K/CLDNs信号通路诱导卵巢癌细胞氧化应激和DNA损伤

Î²-estradiol alleviates hypoxic-ischemic brain damage in neonatal rats through the GPER1-mediated AKT/NF-ÎºB signaling pathway.

β-雌二醇通过GPER1介导的AKT/NF-κB信号通路减轻新生大鼠的缺氧缺血性脑损伤。

Sex-informed estrogen receptor modulation in schizophrenia: a male-focused ERβ/GPER1 framework for cognitive and negative symptoms

精神分裂症中基于性别的雌激素受体调节：以男性为中心的ERβ/GPER1框架治疗认知和阴性症状

Attenuation of Hypertension and protection of vascular inflammation in hyperaldosteronism: GPER1 as potential therapeutic candidate when MR antagonist is less satisfying?

GPER1能否作为治疗醛固酮增多症的潜在候选药物，以减轻高血压并保护血管免受炎症影响？当盐皮质激素受体拮抗剂疗效不佳时，GPER1是否可作为潜在的治疗靶点？