日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants

蛋白酶激活受体-1的信号偏向性由不同的GRK5和β-arrestin-2决定簇决定

期刊:Cell Reports
影响因子:6.9
doi:10.1016/j.celrep.2026.117041
Gonzalez Ramirez, Monica L; Orduña-Castillo, Lennis B; Bardeleben, Carolyne; Qin, Huaping; Lin, Ying; Birch, Cierra A; Kufareva, Irina; Trejo, JoAnn
信号转导
GRK5
发表日期：2026
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Revealing GRK5 Activation Features by Interpretable Machine Learning and Molecular Dynamics Simulation

利用可解释机器学习和分子动力学模拟揭示GRK5激活特征

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27073329
Song, Yuanpeng; Kong, Ming; Zhang, Fuhui; Pu, Xuemei
GRK5
发表日期：2026
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Activated protein C drives β-arrestin-2- and c-Src-dependent phosphorylation of Cav1 and modulates Cav1 association with PAR1 and GRK5.

活化蛋白 C 驱动 β-arrestin-2 和 c-Src 依赖的 Cav1 磷酸化，并调节 Cav1 与 PAR1 和 GRK5 的结合。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111190
Qin Huaping, Orduña-Castillo Lennis B, Molinar-Inglis Olivia, Gonzalez Ramirez Monica L, Lopez-Ramirez Miguel A, Bardeleben Carolyne, Trejo JoAnn
SRC
CAV1
REST
GRK5
磷酸化
发表日期：2026
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G Protein-Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons

G蛋白偶联受体激酶5 (GRK5) 调节大鼠交感神经元中伤害感受素/孤啡肽FQ阿片(NOP)受体的脱敏作用

期刊:Journal of Neuroscience Research
影响因子:3.4
doi:10.1002/jnr.70110
Farrag, Mohamed; Soliman, Marwa; Mahmoud, Saifeldin; Miller, Lauren; Herold, Paul B; Brandt, Kristen; Ruiz-Velasco, Victor
Rat
信号转导
GRK5
神经科学
发表日期：2026
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High-Throughput Cardiac Hypertrophy Phenotyping Supports Lead Optimization of GRK5 Inhibitors

高通量心脏肥大表型分析支持GRK5抑制剂的先导化合物优化

期刊:ACS Medicinal Chemistry Letters
影响因子:
doi:10.1021/acsmedchemlett.5c00528
Steinkuhl, Pia; Remes, Anca Kliesow; García, Carmen Carrillo; Sonawane, Amol; Gadi, Ranjith Kumar; Ghosh, Arun K; Tesmer, John J G; Müller, Oliver J; Schade, Dennis
GRK5
发表日期：2026
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Potential Cardioprotective Effect of a GRK5 Inhibitor Against NF-κB-Mediated Inflammation in an Animal Model of Isoproterenol-Induced Myocardial Infarction

GRK5抑制剂对异丙肾上腺素诱导心肌梗死动物模型中NF-κB介导的炎症的潜在心脏保护作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27010053
Alonazi, Asma S; Bin Dayel, Anfal F; Alkhathlan, Bashayer A; Alkaff, Lulu M; Alrashed, Ahad T; Bin Klaib, Reema A; Elnagar, Doaa M; Alamin, Maha A; Ali, Rehab A; Alameen, Alaa Alnoor; Alrasheed, Nouf M
GRK5
炎症
炎症/感染
NF-κB
Immunology/Inflammation
心血管
心肌梗塞
免疫/内分泌
发表日期：2025
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GRK5 regulates endocytosis of FPR2 independent of β-arrestins

GRK5 独立于 β-arrestins 调控 FPR2 的内吞作用。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2024.108112
Jack, Christine E; Cope, Emily M; Lemel, Laura; Canals, Meritxell; Drube, Julia; Hoffmann, Carsten; Inoue, Asuka; Hislop, James N; Thompson, Dawn
信号转导
GRK5
FPR2
发表日期：2025
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GRK5 is required for adipocyte differentiation through ERK activation

GRK5通过ERK激活参与脂肪细胞分化。

期刊:International Journal of Obesity
影响因子:3.8
doi:10.1038/s41366-025-01712-w
Seramur, Mary E; McDonald, Bailey; Davis, Matt; Reeves, Tony E; Solberg Woods, Leah C; Chuang Key, Chia-Chi
MAPK/ERK
细胞生物学
GRK5
发表日期：2025
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A GRK5 centered prognostic framework for bladder cancer based on palmitoylation and epigenetic regulation

基于棕榈酰化和表观遗传调控的GRK5中心膀胱癌预后框架

期刊:Discover Oncology
影响因子:2.9
doi:10.1007/s12672-025-03563-3
Liu, Junpeng; Zhang, Zeke; Huang, Bin; Fang, Yutong; Lin, Hao
肿瘤
GRK5
表观遗传
肿瘤免疫
信号转导
膀胱癌
发表日期：2025
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Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants

蛋白酶激活受体-1的信号偏向性由不同的GRK5和β-arrestin-2决定簇决定

期刊:
影响因子:
doi:10.1101/2025.11.02.686167
Gonzalez Ramirez, Monica L; Orduña-Castillo, Lennis B; Bardeleben, Carolyne; Qin, Huaping; Lin, Ying; Birch, Cierra A; Kufareva, Irina; Trejo, JoAnn
信号转导
GRK5
发表日期：2025
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