日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A B7H3-targeting antibody-drug conjugate in advanced solid tumors: a phase 1/1b trial.

针对晚期实体瘤的 B7H3 靶向抗体药物偶联物:一项 1/1b 期试验

Ma Yuxiang, Yang Yunpeng, Huang Yan, Fang Wenfeng, Xue Jinhui, Meng Xiangjiao, Fan Yun, Fu Siqing, Wu Lin, Zheng Yulong, Liu Jian, Liu Zhihua, Zhuang Wu, Rosen Seth, Qu Song, Li Bihui, Li Mingjun, Zhao Yanqiu, Yang Shujun, Ji Yinghua, Sommerhalder David, Luo Suxia, Yang Kunyu, Li Jingao, Lv Dongqing, Zhang Peng, Zhao Yuanyuan, Hong Shaodong, Zhang Yang, Zhao Shen, Chin Steve, Zhang Xian, Lian Wei, Cai Jiaqiang, Xue Tongtong, Zhang Li, Zhao Hongyun

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

KDM4C 抑制剂通过促进组织蛋白酶 L 介导的组蛋白 H3 裂解来阻断基底型乳腺癌的肿瘤生长

Li Zheqi, Peluffo Guillermo, Stevens Laura E, Qiu Xintao, Seehawer Marco, Tawawalla Amatullah, Huang Xiao-Yun, Egri Shawn B, Raval Shaunak, McFadden Maeve, D'Santos Clive S, Papachristou Eva, Kingston Natalie L, Nishida Jun, Evans Kyle E, Seo Ji-Heui, Clement Kendell, Temko Daniel, Ekram Muhammad, Li Rong, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Simeonov Anton, Kales Stephen C, Rai Ganesha, Lal-Nag Madhu, Maloney David J, Jadhav Ajit, Michor Franziska, Meissner Alex, Balko Justin M, Carroll Jason S, Freedman Matthew L, Jaffe Jacob D, Papanastasiou Malvina, Long Henry W, Polyak Kornelia

Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis.

Hbo1 和 Msl 复合物在有丝分裂过程中保持活性和非活性 X 染色体的差异性压缩和 H3K27me3 标记

Djeghloul Dounia, Cheriyamkunnel Sherry, Patel Bhavik, Kramer Holger, Montoya Alex, Brown Karen E, Whilding Chad, Nesterova Tatyana B, Wei Guifeng, Brockdorff Neil, GrzÄ dzielewska Iga, Karayol Remzi, Akhtar Asifa, Merkenschlager Matthias, Fisher Amanda G

Genome-wide in vivo and ex vivo mapping of R-loops using engineered N-terminal hybrid-binding domain of RNase H3 (enDR3)

利用工程化的 RNase H3 N 端杂合结合域 (enDR3) 对 R 环进行全基因组体内和体外定位

Marta Jedynak-Slyvka ,Zuzanna Kaczmarska ,Damian Graczyk ,Aneta Jurkiewicz ,Małgorzata Figiel ,Lukasz S Borowski, Roman J Szczesny ,Marcin Nowotny

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells.

H3.3 沉积抵消了胚胎干细胞染色中心处 H3.1 的复制依赖性富集

Arfè S, Karagyozova T, Forest A, Bingham D, Hmidan H, Mazaud D, Garnier M, Le Baccon P, Meshorer E, Quivy J-P, Almouzni G

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

靶向 BCL-XL 的 BH3 模拟物对 RB1 缺失和复制压力的实体瘤有效

Varkaris Andreas, Wang Keshan, Nouri Mannan, Kozlova Nina, Schmidt Daniel R, Stavridi Anastasia, Arai Seiji, Ambrosio Nicholas, Poluben Larysa, Jimenez-Vacas Juan M, Westaby Daniel, Carmichael Juliet, Xie Fang, Figueiredo Ines, Buroni Lorenzo, Neeb Antje, Gurel Bora, Chevalier Nicholas, Brown Lisha, Voznesensky Olga, Chen Shao-Yong, Russo Joshua W, Yuan Xin, Juric Dejan, Beltran Himisha, De Bono Johann S, Vander Heiden Matthew G, Einstein David J, Muranen Taru, Corey Eva, Sharp Adam, Balk Steven P

Dual mitotic bookmarking by GAF and H3K27ac orchestrates differential propagation of cell fate memory in neural development.

GAF 和 H3K27ac 的双重有丝分裂标记协调神经发育过程中细胞命运记忆的差异性传播

Zhang Rulan, Liu Jie, Zhang Zimo, Chen Zili, Wang Tanpeng, Shen Yuying, Lan Zejun, Chu Jingyi, Tang Haoxuan, Zhang Xiyue, Song Yan

Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells.

GCGR/GLP1R 信号的双重激活通过代谢调节上皮细胞中的组蛋白 H3K9 乳酸化来改善肠道纤维化

Liu Han, Hong Yujie, Chen Hui, Wang Xianggui, Dong Jiale, Li Xiaoqian, Shi Zihan, Zhao Qian, Zhou Longyuan, Wang JiaXin, Zeng Qiuling, Tang Qinglin, Liu Qi, Rieder Florian, Chen Baili, Chen Minhu, Wang Rui, Zhang Yao, Mao Ren, Jiang Xianxing

ALKBH3-regulated m(1)A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells.

ALKBH3 调控的 ALDOA 的 m(1)A 增强了三阴性乳腺癌细胞的糖酵解和阿霉素耐药性

Deng Yuhua, Chen Zhiyan, Chen Peixian, Xiong Yaming, Zhang Chuling, Wu Qiuyuan, Huang Huiqi, Yang Shuqing, Zhang Kun, He Tiancheng, Li Wei, Ye Guolin, Luo Wei, Wang Hongsheng, Zhou Dan

SNORA74A Drives Self-Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling.

SNORA74A 通过激活 Notch3 信号通路驱动肝癌干细胞的自我更新和肝癌发生

Zhou Ziheng, Gu Yang, Yi Zhibin, Wang Jianyi, Xiong Zhen, Guo Hui, Du Ying, Zhu Xiaoxiao, He Lei, Ren Weizheng, Tian Yong, Wang Yanying, Fan Zusen