HDAC6相关文献与解析，生知库 | 链接生命科学的每一步

HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-Î²/SMAD and CSF1R signaling.

HDAC6 通过 S100A2-TGF-β/SMAD 和 CSF1R 信号传导来调控小细胞肺癌的转移和免疫抑制程序。

Jiang Yantao, Yu Junjie, Wang Ting, Du Qingwu, Wang Jingya, Lu Yi, Xu Qi, Liu Huiyan, Li Xueyang, Tong Luyao, Qin Tingting, Huang Dingzhi

肺癌

The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition

黏着斑激酶调节瘦素的作用以及HDAC6抑制剂的减重效果。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-026-69008-9

Hadley, Colleen K; Galgano, Luca; Gui, Yijun; Carvalho da Silva, Antonio M; Porter, Danielle T; Wu, Yanan; Lai, Yuanting; Torti, Mauro; Çakır, Işın

Development of a novel HDAC6 PET imaging agent uncovers associations between HDAC6 overexpression and neuroinflammation in depression.

新型 HDAC6 PET 成像剂的开发揭示了 HDAC6 过度表达与抑郁症神经炎症之间的关联。

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2026.104014

Immunology/Inflammation

炎症

发表日期：2026

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ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming.

ATF3 通过 HDAC6 依赖的表观遗传重编程加剧肾纤维化。

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.125062

Tao Sibei, Wu Chenzhou, Yu Fanyuan, Yang Lina, Li Lingzhi, Guo Fan, Xiang Ting, Ma Liang, Fu Ping

Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells

通过抑制HDAC6进行表观遗传重塑可增强髓系白血病细胞的抗肿瘤免疫反应。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08541-3

Schliehe-Diecks, Julian; Tu, Jia-Wey; Stachura, Pawel; Schaal, Katerina; Kemkes, Marie; Vasileiou, Eleni; Rüchel, Nadine; Brandes, Danielle; Vogt, Melina; Lenz, Thomas; Nair, Adarsh; Scheu, Stefanie; Dominguez, Pilar M; Pastorczak, Agata; Nebral, Karin; Stühler, Kai; Fischer, Ute; Pandyra, Aleksandra A; Borkhardt, Arndt; Bhatia, Sanil

Author Correction: HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype

作者更正：HDAC6 通过诱导 EMT 和增强巨噬细胞向 M2 表型极化来促进 LUAD 的进展

期刊:npj Precision Oncology

影响因子:8

doi:10.1038/s41698-026-01376-3

Jiang, Yantao; Zhang, Ju; Yu, Junjie; Luo, Wei; Du, Qingwu; Liu, Wenting; Xu, Qi; Li, Xueyang; Liu, Huiyan; Huang, Dingzhi; Qin, Tingting

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.

利用富含皮质脊髓运动神经元的皮质类器官对痉挛性截瘫 4 进行建模，揭示了基因型-表型和 HDAC6 可靶向的病理。

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2026.117036

Mohan Neha, Ramakrishnan Skandha, Sun Xiaohuan, Sun Ying, Connors Theresa, Chai Victor, Piermarini Emanuela, Baas Peter W, Cai James, Liu Mei, Qiang Liang

Correction: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex

更正：RBX1通过破坏SMAR1/HDAC6复合物来调控PKM选择性剪接，从而促进未分化型甲状腺癌转移和有氧糖酵解。

期刊:Cell and Bioscience

影响因子:6.2

doi:10.1186/s13578-026-01560-9

Xu, Debin; Yu, Jichun; Yang, Yuting; Du, Yunyan; Lu, Hongcheng; Zhang, Shouhua; Feng, Qian; Yu, Yi; Hao, Liang; Shao, Jun; Chen, Leifeng

High-effect synergy from dual HDAC6 and YAP-TEAD inhibition in ovarian clear cell carcinoma.

双重抑制 HDAC6 和 YAP-TEAD 对卵巢透明细胞癌具有高度协同作用。

期刊:Cancer Cell International

影响因子:6

doi:10.1186/s12935-026-04204-7

Zaitsu Sumika, Yano Mitsutake, Sakashita Sohei, Miwa Maiko, Yasuda Masanori, Kobayashi Eiji, Matsuura Keiko

DCLK1 drives malignant progression and chemoresistance of bladder cancer by deubiquitinating HDAC6.

DCLK1 通过去泛素化 HDAC6 来驱动膀胱癌的恶性进展和化疗耐药性。

HDAC6 orchestrates metastatic and immunosuppressive programs in small cell lung cancer through S100A2-TGF-Î²/SMAD and CSF1R signaling.

HDAC6 通过 S100A2-TGF-β/SMAD 和 CSF1R 信号传导来调控小细胞肺癌的转移和免疫抑制程序。

The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition

黏着斑激酶调节瘦素的作用以及HDAC6抑制剂的减重效果。

Development of a novel HDAC6 PET imaging agent uncovers associations between HDAC6 overexpression and neuroinflammation in depression.

新型 HDAC6 PET 成像剂的开发揭示了 HDAC6 过度表达与抑郁症神经炎症之间的关联。

ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming.

ATF3 通过 HDAC6 依赖的表观遗传重编程加剧肾纤维化。

Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells

通过抑制HDAC6进行表观遗传重塑可增强髓系白血病细胞的抗肿瘤免疫反应。

Author Correction: HDAC6 facilitates LUAD progression by inducing EMT and enhancing macrophage polarization towards the M2 phenotype

作者更正：HDAC6 通过诱导 EMT 和增强巨噬细胞向 M2 表型极化来促进 LUAD 的进展

Modeling spastic paraplegia 4 with corticospinal motor neuron-enriched cortical organoids reveals genotype-phenotype and HDAC6-targetable pathology.

利用富含皮质脊髓运动神经元的皮质类器官对痉挛性截瘫 4 进行建模，揭示了基因型-表型和 HDAC6 可靶向的病理。

Correction: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex

更正：RBX1通过破坏SMAR1/HDAC6复合物来调控PKM选择性剪接，从而促进未分化型甲状腺癌转移和有氧糖酵解。

High-effect synergy from dual HDAC6 and YAP-TEAD inhibition in ovarian clear cell carcinoma.

双重抑制 HDAC6 和 YAP-TEAD 对卵巢透明细胞癌具有高度协同作用。