HMGB1相关文献与解析，生知库 | 链接生命科学的每一步

Identification of HMGB1 as a target of 3-O-benzoyl-20-deoxyingenol in NSCLC therapy using integrated ABPP and SIP

利用整合的ABPP和SIP技术，鉴定出HMGB1是3-O-苯甲酰基-20-脱氧英格醇在非小细胞肺癌治疗中的靶点。

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2026.01.043

Wang, Yaxu; Liu, Yan; Zhuang, Yuan; Luo, Wennan; Pan, Lu; Gu, Liwei; Wang, Jigang; Liu, Qingbo; Song, Shao-Jiang

MdHMGB15-MdXERICO-MdNRP module mediates salt tolerance of apple by regulating the expression of salt stress-related genes

MdHMGB15-MdXERICO-MdNRP模块通过调控盐胁迫相关基因的表达来介导苹果的耐盐性。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2025.03.040

Liu, Ran-Xin; Li, Shan-Shan; Yue, Qian-Yu; Li, Hong-Liang; Lu, Jie; Li, Wan-Cong; Wang, Yue-Ning; Liu, Jia-Xing; Guo, Xin-Long; Wu, Xiang; Lv, Ying-Xue; Wang, Xiao-Fei; You, Chun-Xiang

The redox-sensitive protein HMGB1: intracellular and extracellular roles

氧化还原敏感蛋白HMGB1：细胞内和细胞外作用

期刊:Experimental and Molecular Medicine

影响因子:12.9

doi:10.1038/s12276-026-01640-3

Kwak, Man Sup; Jung, Su Ful; Park, In Ho; Shin, Jeon-Soo

Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.

促进 HMGB1 在细胞核内的滞留可减轻星形胶质细胞衰老。

期刊:Journal of Neuroinflammation

影响因子:10.1

doi:10.1186/s12974-025-03684-0

Zhang Na, Yang Fan, Shi Junyu, Tang Xuhuan, Fan Anqi, Li Wenhua, Zhang Feng, Chai Shuaishuai, Chen Qun, Wang Chenchen, Xu Yong, Gong Feili, Lu Yisheng, Zheng Fang

iRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia-reperfusion injury

iRhom2通过调节HMGB1分泌来调控缺血再灌注损伤体外模型中的炎症和肝细胞衰老。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08256-x

Calligaris, Matteo; Perriera, Riccardo; Carcione, Claudia; Miceli, Vitale; Pinto, Margot Lo; Busà, Rosalia; Amico, Giandomenico; Bulati, Matteo; Amato, Caterina; Pagano, Duilio; Conaldi, Pier Giulio; Scilabra, Simone Dario; Pinzani, Massimo; Zito, Giovanni

Correction: 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1

更正：4-胆甾烯-3-酮通过调节HMGB1、HIF1α和Caveolin-1的易位抑制肺腺癌转移

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08408-z

Ma, Jinben; Fu, Guobin; Wu, Jing; Han, Shaoxian; Zhang, Lishan; Yang, Ming; Yu, Yong; Zhang, Mengyuan; Lin, Yanliang; Wang, Yibing

cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.

LRRK2 诱导的 cGAS-STING/HMGB1 介导的衰老加速骨关节炎中的软骨退化。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-026-08651-y

Zhang Yantao, Zhu Zhenxing, Ji Piyao, Ming Jianghua, Zhou Yan

The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury

m5C 调控因子 NSUN7 驱动 SPARC/HMGB1 轴介导的炎症反应，从而加剧肾损伤。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2511296123

Dong, Yu-Hang; Xie, Shuai-Shuai; Sun, Shuai; Ren, Yu; Yang, Qin; Wei, Jie; Hou, Rui; Li, Xiang-Yu; Wu, Jing-Wen; Ma, Wen-Xian; Yu, Ju-Tao; He, Meng-Ting; Li, Chao; Wang, Jia-Nan; Ji, Ming-Lu; Liu, Zi-Yi; Dong, Ze-Hui; Shen, Xiao-Yu; Chen, Xin-Yu; Suo, Xiao-Guo; Dong, Wei; Jin, Juan; Wang, Jie; Wang, Wen-Bin; Meng, Xiao-Ming

Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1/TLR4/NF-κB modulation in a rat model of huntington's disease

在亨廷顿病大鼠模型中，青蒿素通过调节HMGB1/TLR4/NF-κB通路减轻3-硝基丙酸诱导的神经退行性变。

期刊:Archives of Pharmacal Research

影响因子:7.5

doi:10.1007/s12272-026-01604-1

Mustafa, Aya M; Mudhafar, Mustafa; Elgindy, Ali M; Esmail, Manar M; Atwa, Ahmed M; Shaheen, Aya M; Radwan, Abdullah F; Elfar, Nourhan; Mohamed, Ruaa Yasir Altayeb; Gamil, Noha M

HMGB1 functions as a critical mediator of host defense at the gut mucosal barrier.

HMGB1 在肠道粘膜屏障中发挥着宿主防御的关键介质的作用。

Identification of HMGB1 as a target of 3-O-benzoyl-20-deoxyingenol in NSCLC therapy using integrated ABPP and SIP

利用整合的ABPP和SIP技术，鉴定出HMGB1是3-O-苯甲酰基-20-脱氧英格醇在非小细胞肺癌治疗中的靶点。

MdHMGB15-MdXERICO-MdNRP module mediates salt tolerance of apple by regulating the expression of salt stress-related genes

MdHMGB15-MdXERICO-MdNRP模块通过调控盐胁迫相关基因的表达来介导苹果的耐盐性。

The redox-sensitive protein HMGB1: intracellular and extracellular roles

氧化还原敏感蛋白HMGB1：细胞内和细胞外作用

Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence.

促进 HMGB1 在细胞核内的滞留可减轻星形胶质细胞衰老。

iRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia-reperfusion injury

iRhom2通过调节HMGB1分泌来调控缺血再灌注损伤体外模型中的炎症和肝细胞衰老。

Correction: 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1

更正：4-胆甾烯-3-酮通过调节HMGB1、HIF1α和Caveolin-1的易位抑制肺腺癌转移

cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.

LRRK2 诱导的 cGAS-STING/HMGB1 介导的衰老加速骨关节炎中的软骨退化。

The m5C orchestrator NSUN7 drives SPARC/HMGB1 axis-mediated inflammation to exacerbate kidney injury

m5C 调控因子 NSUN7 驱动 SPARC/HMGB1 轴介导的炎症反应，从而加剧肾损伤。

Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1/TLR4/NF-κB modulation in a rat model of huntington's disease

在亨廷顿病大鼠模型中，青蒿素通过调节HMGB1/TLR4/NF-κB通路减轻3-硝基丙酸诱导的神经退行性变。