日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Endothelial cell-derived extracellular vesicles modulate the therapeutic efficacy of mesenchymal stem cells through IDH2/TET pathway in ARDS

内皮细胞来源的细胞外囊泡通过IDH2/TET通路调节间充质干细胞在ARDS中的治疗效果。

Xiao Wu # ,Ying Tang # ,Xinxing Lu ,Yigao Liu ,Xu Liu ,Qin Sun ,Lu Wang ,Wei Huang ,Airan Liu ,Ling Liu ,Jie Chao ,Xiwen Zhang ,Haibo Qiu

A study to assess the efficacy of enasidenib and risk-adapted addition of azacitidine in newly diagnosed IDH2-mutant AML

一项评估enasidenib联合风险适应性加用阿扎胞苷治疗新诊断的IDH2突变型急性髓系白血病疗效的研究

Sheng F Cai ,Ying Huang ,Jennie R Lance ,Hsiaoyin Charlene Mao ,Andrew J Dunbar ,Samantha N McNulty ,Todd Druley ,Yan Li ,Maria R Baer ,Wendy Stock ,Tibor Kovacsovics ,William G Blum ,Gary J Schiller ,Rebecca L Olin ,James M Foran ,Mark Litzow ,Tara Lin ,Prapti Patel ,Matthew C Foster ,Michael Boyiadzis ,Robert H Collins ,Jordan Chervin ,Abigail Shoben ,Jo-Anne Vergilio ,Nyla A Heerema ,Leonard Rosenberg ,Timothy L Chen ,Ashley O Yocum ,Franchesca Druggan ,Sonja Marcus ,Mona Stefanos ,Brian J Druker ,Alice S Mims ,Uma Borate ,Amy Burd ,John C Byrd ,Ross L Levine ,Eytan M Stein

Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells

磷脂代谢适应促进IDH2突变型急性髓系白血病细胞的存活

Tatsuya Morishima ,Koichi Takahashi ,Desmond Wai Loon Chin ,Yuxin Wang ,Kenji Tokunaga ,Yuichiro Arima ,Masao Matsuoka ,Toshio Suda ,Hitoshi Takizawa

IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer

IDH2 可稳定 HIF-1α 诱导的代谢重编程,并促进尿路上皮癌的化疗耐药性。

Keisuke Shigeta ,Masanori Hasegawa ,Takako Hishiki ,Yoshiko Naito ,Yuto Baba ,Shuji Mikami ,Kazuhiro Matsumoto ,Ryuichi Mizuno ,Akira Miyajima ,Eiji Kikuchi ,Hideyuki Saya ,Takeo Kosaka ,Mototsugu Oya

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

赖氨酸乙酰化限制突变型IDH2活性,从而优化AML细胞的转化。

Dong Chen ,Siyuan Xia ,Rukang Zhang ,Yuancheng Li ,Christopher A Famulare ,Hao Fan ,Rong Wu ,Mei Wang ,Allen C Zhu ,Shannon E Elf ,Rui Su ,Lei Dong ,Martha Arellano ,William G Blum ,Hui Mao ,Sagar Lonial ,Wendy Stock ,Olatoyosi Odenike ,Michelle Le Beau ,Titus J Boggon ,Chuan He ,Jianjun Chen ,Xue Gao ,Ross L Levine ,Jing Chen

Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

突变型Idh2与NUP98-HOXD13融合蛋白协同诱导早期未成熟胸腺细胞前体ALL

Liat Goldberg # ,Vijay Negi # ,Yang Jo Chung ,Masahiro Onozawa ,Yuelin J Zhu ,Robert L Walker ,Rachel Pierce ,Daxesh P Patel ,Kristopher W Krausz ,Frank J Gonzalez ,Margaret A Goodell ,Benjamin A T Rodriguez ,Paul S Meltzer ,Peter D Aplan

Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome

线粒体磷酸载体SLC25A3的缺失会诱导心脏线粒体蛋白酰基组的重塑。

Jessica N Peoples ,Nasab Ghazal ,Duc M Duong ,Katherine R Hardin ,Janet R Manning ,Nicholas T Seyfried ,Victor Faundez ,Jennifer Q Kwong

Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

注册报告:白血病相关IDH1和IDH2突变的共同特征是产生一种新的酶活性,可将α-酮戊二酸转化为2-羟基戊二酸。

Oliver Fiehn ,Megan Reed Showalter ,Christine E Schaner-Tooley

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

突变型IDH2产生的D-2-羟基戊二酸会导致小鼠心肌病和神经退行性变。

Esra A Akbay ,Javid Moslehi, Camilla L Christensen, Supriya Saha, Jeremy H Tchaicha, Shakti H Ramkissoon, Kelly M Stewart, Julian Carretero, Eiki Kikuchi, Haikuo Zhang, Travis J Cohoon, Stuart Murray, Wei Liu, Kazumasa Uno, Sudeshna Fisch, Kristen Jones, Sushma Gurumurthy, Camelia Gliser, Sung Choe, Marie Keenan, Jaekyoung Son, Illana Stanley, Julie A Losman, Robert Padera, Roderick T Bronson, John M Asara, Omar Abdel-Wahab, Philip C Amrein, Amir T Fathi, Nika N Danial, Alec C Kimmelman, Andrew L Kung, Keith L Ligon, Katharine E Yen, William G Kaelin Jr, Nabeel Bardeesy, Kwok-Kin Wong