日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An activity-specificity trade-off encoded in human transcription factors

人类转录因子编码的活性特异性权衡

Julian Naderi #, Alexandre P Magalhaes #, Gözde Kibar, Gregoire Stik, Yaotian Zhang, Sebastian D Mackowiak, Hannah M Wieler, Francesca Rossi, Rene Buschow, Marie Christou-Kent, Marc Alcoverro-Bertran, Thomas Graf, Martin Vingron, Denes Hnisz

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

利用具有复制能力的HIV引导的CRISPR筛选,可以鉴定出包括辅助蛋白Nef靶点在内的抗病毒因子。

Caterina Prelli Bozzo # ,Alexandre Laliberté # ,Aurora De Luna ,Chiara Pastorio ,Kerstin Regensburger ,Stefan Krebs ,Alexander Graf ,Helmut Blum ,Meta Volcic ,Konstantin M J Sparrer ,Frank Kirchhoff

Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages

多细胞生态型影响肺腺癌从磨玻璃样混浊发展到晚期的过程

Yulan Deng ,Liang Xia ,Jian Zhang ,Senyi Deng ,Mengyao Wang ,Shiyou Wei ,Kaixiu Li ,Hongjin Lai ,Yunhao Yang ,Yuquan Bai ,Yongcheng Liu ,Lanzhi Luo ,Zhenyu Yang ,Yaohui Chen ,Ran Kang ,Fanyi Gan ,Qiang Pu ,Jiandong Mei ,Lin Ma ,Feng Lin ,Chenglin Guo ,Hu Liao ,Yunke Zhu ,Zheng Liu ,Chengwu Liu ,Yang Hu ,Yong Yuan ,Zhengyu Zha ,Gang Yuan ,Gao Zhang ,Luonan Chen ,Qing Cheng ,Shensi Shen ,Lunxu Liu

IFI16 phase separation via multi-phosphorylation drives innate immune signaling

IFI16通过多重磷酸化实现相分离,从而驱动先天免疫信号传导

Dawei Liu,Krystal K Lum,Nicholas Treen,Corazón T Núñez,Jinhang Yang,Timothy R Howard,Michael Levine,Ileana M Cristea

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

DNA-PKcs 是人类细胞中 cGAS/STING 依赖性病毒 DNA 感应所必需的

Dayana B Hristova, Marisa Oliveira, Emma Wagner, Alan Melcher, Kevin J Harrington, Alexandre Belot, Brian J Ferguson

Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells

Sirt1 通过阻止人类细胞中干扰素诱导蛋白 16 的细胞质易位来负面调节细胞抗病毒反应

Jie Wang #, Xiao Qin #, Yulu Huang #, Ge Zhang, Yue Liu, Yuhan Cui, Yi Wang, Jinyong Pei, Shujun Ma, Zhishan Song, Xiaofei Zhu, Hui Wang, Bo Yang

Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer

I 型干扰素刺激脂肪细胞中 IFI16 介导的芳香化酶表达,促进 ER 阳性乳腺癌的 E2 依赖性生长

Na-Lee Ka, Ga Young Lim, Seung-Su Kim, Sewon Hwang, Juhyeong Han, Yun-Hee Lee, Mi-Ock Lee

IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection

IFI16 影响人类巨细胞病毒感染期间的代谢重编程

Gloria Griffante, Weronika Hewelt-Belka, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Greta Bajetto, Paolo Ettore Porporato, Erica Mina, Marta Vallino, Christian Krapp, Martin Roelsgaard Jakobsen, John Purdy, Jens von Einem, Santo Landolfo, Valentina Dell'Os

The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection

核 DNA 传感器 IFI16 不加区分地与 HSV-1 基因组结合并降低其可及性以抑制感染

Timothy R Howard, Krystal K Lum, Michelle A Kennedy, Ileana M Cristea

The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum

患有结节性红斑的多菌性麻风病患者的皮肤病变和血液中 I 型干扰素通路上调

Thabatta Leal Silveira Andrezo Rosa, Mayara Abud Mendes, Natasha Ribeiro Cardoso Linhares, Thais Fernanda Rodrigues, André Alves Dias, Thyago Leal-Calvo, Mariana Gandini, Helen Ferreira, Fabrício da Mota Ramalho Costa, Anna Maria Sales, Thaís Porto Amadeu, Veronica Schmitz, Roberta Olmo Pinheiro, Lu