日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.

IFNγ依赖性代谢重编程抑制黑色素瘤中不成熟的、促转移的淋巴状态。

Defining lytic IFNγ for deciphering the CTL mechanism

定义裂解性IFNγ以解析CTL机制

Park, Jaewoo; Lee, SangJoon

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing

裂解性IFNγ储存在细胞毒性颗粒中,并与颗粒酶B共同释放,介导细胞毒性T淋巴细胞杀伤作用。

Li, Xuemei; Schirra, Claudia; Wirkner, Marie-Louise; Tu, Szu-Min; Lin, Chin-Hsin; Hohmann, Meltem; Gu, Yuan; Santiago, Llipsy; Pardo, Julian; Arretxe, Iñaki; Alawar, Nadia; Chouaib, Abed Alrahman; Becherer, Ute; Lee, Po-Hsien; Hsu, Hao-Jen; Laschke, Matthias W; Baldari, Cosima T; Dustin, Michael L; Rettig, Jens; Krause, Elmar; Chang, Hsin-Fang

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.

AGPAT3 通过脂质重塑改变肿瘤细胞对 IFNγ 介导的铁死亡的敏感性,并增强免疫疗法的疗效。

Liu Chuan, Hu Chuan, Cheng Jinlin, Xin Duanfeng, Jin Sujie, Tian Weihong, Li Shan, Jin Yuzhi, Liu Yu, Wu Wei, Hao Shuqiang, Ren Hui, Dai Xiaomeng, Liu Lulu, Ruan Jian, Fang Weijia, Bao Xuanwen, Xin Shan, Zhao Peng

IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself.

IFNγ诱导的人类巨噬细胞记忆是由细胞因子信号本身的持久性维持的。

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation.

LRRK2 激酶介导小胶质细胞中 GCase 活性增加,以响应 IFNγ 诱导的促炎刺激。

MacDougall Emma J, Chen Carol X-Q, Deneault Eric, You Zhipeng, Kalaydjian David, Abdian Narges, Durcan Thomas M, Senkevich Konstantin, Gan-Or Ziv, Fon Edward A

IL17F(+) naïve and IFNγ(+) memory CD8 T cells drive hepatic dysfunction in the cecal ligation and puncture model of sepsis.

在盲肠结扎穿孔脓毒症模型中,IL17F(+) 幼稚 CD8 T 细胞和 IFNγ(+) 记忆 CD8 T 细胞驱动肝功能障碍。

Taylor Matthew D, Geier Omar, Byskosh Alexandria Z, Murzin Ekaterina, Nedeljkovic-Kurepa Ana, Fisler Grace M, Abraham Mabel N, Brewer Mariana R, Lederer James A, Deutschman Clifford S

TIGIT impairs NK cell antifibrotic activity through the IFNγ-IFI30 axis in schistosomiasis-induced liver fibrosis

TIGIT通过IFNγ-IFI30轴削弱NK细胞在血吸虫病诱导的肝纤维化中的抗纤维化活性

Peng, Hui; Zhang, Jing; Zhang, Xiaocheng; Zhou, Hao; Cui, Lijun; Xu, Fangfang; Jiang, Tingting; Yin, Jianhai; Hu, Yuan; Shen, Yujuan; Lu, Shaohong; Cao, Jianping

IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice

IFNγ相关的免疫代谢重塑与易患狼疮小鼠的血清素-犬尿氨酸失衡和皮质脆弱性有关

Matmat, Karim; Guéant-Rodriguez, Rosa-Maria; Darcq, Emmanuel; Baspinar, Okan; Alberto, Jean-Marc; Guéant, Jean-Louis; Mensah-Nyagan, Ayikoé-Guy; Jeltsch-David, Hélène

IFNγ-induced antigen loss in chimeric antigen receptor-T cell therapy.

IFNγ诱导嵌合抗原受体T细胞疗法中的抗原丢失。

Cao Miao, Alvarez Jasmine, Mitra Ramkrishna, Xu Michael, Baybutt Trevor R, Sun Zhengyang, Taylor Oluwatobiloba, Doermann Allison S, Staudt Ross E, Waldman Scott A, Snook Adam E