日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy

回复:降低小胶质细胞APOE表达的定量性状基因座与脑淀粉样血管病减少相关

Shade, Lincoln M P; Qiao, Qi; Katsumata, Yuriko; Mukherjee, Shubhabrata; Broome, Jai G; Johnson, Lance A; Ebbert, Mark T W; Nelson, Peter T; Fardo, David W

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer's disease pathogenesis

神经元APOE4诱导的早期海马网络过度兴奋与阿尔茨海默病发病机制

Tabuena, Dennis R; Jang, Sung-Soo; Grone, Brian; Yip, Oscar; Aery Jones, Emily A; Blumenfeld, Jessica; Liang, Zherui; Mann, Rajkamalpreet S; Li, Yaqiao; Necula, Deanna; Koutsodendris, Nicole; Rao, Antara; Ding, Leonardo; Zhang, Alex R; Hao, Yanxia; Xu, Qin; Yoon, Seo Yeon; De Leon, Samuel; Huang, Yadong; Zilberter, Misha

A common 19 bp APOE enhancer deletion is protective against Alzheimer's disease in African Americans

一种常见的19 bp APOE增强子缺失对非裔美国人具有预防阿尔茨海默病的作用

Brutman, Julianna N; Busald, Tina; Nizamis, Evangelos; Kaufman, Eli J; Lin, Eugene; Hendricks, Nzinga E; Chintamen, Sana; Sulovari, Arvis; Smukowski, Samuel N; Ye, Yidian; Peikon, Ian; Jayadev, Suman; Logsdon, Benjamin A; Wijsman, Ellen M; Blue, Elizabeth E; Valdmanis, Paul N

Genetic modifiers of APOE-ε4-associated cognitive decline

APOE-ε4相关认知衰退的遗传修饰因子

Contreras, Alex G; Walters, Skylar; Eissman, Jaclyn M; Archer, Derek B; Regelson, Alexandra N; Durant, Alaina; Clifton, Michelle; Mukherjee, Subhabrata; Lee, Michael L; Choi, Seo-Eun; Scollard, Phoebe; Trittschuh, Emily H; Mez, Jesse; Bush, William S; Kunkle, Brian W; Cruchaga, Carlos; Naj, Adam C; Gifford, Katherine A; Bilgel, Murat; Kuzma, Amanda B; Cuccaro, Michael L; Pericak-Vance, Margaret A; Farrer, Lindsay A; Wang, Li-San; Schellenberg, Gerard D; Haines, Jonathan L; Jefferson, Angela L; Kukull, Walter A; Keene, C Dirk; Saykin, Andrew J; Thompson, Paul M; Martin, Eden R; Albert, Marilyn S; Johnson, Sterling C; Engelman, Corinne D; Ferrucci, Luigi; Bennett, David A; Barnes, Lisa L; Schneider, Julie A; Sperling, Reisa A; Resnick, Susan M; Crane, Paul K; Dumitrescu, Logan; Hohman, Timothy J

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.

性别特异性的 APOE4 依赖性先天免疫调节脑膜淋巴管、脑脂质、神经炎症和认知。

Delivanoglou Nickoleta, Todd Kennedi T, Almeida Francisco, Rego Shanon, Changavi Amogh, Spajer Myriam, Ayuso Virginia Estades, Pinho-Correia Liliana M, Sanchez Guadalupe, das Neves Sofia P, Barber Megan J, Schrader Racquelle, Sacilotto Patricia, Martens Yuka A, Heckman Michael G, Bu Guojun, Tanzi Rudolph E, Thomas Jean-Leon, Fryer John D, Oliveira Tiago Gil, Shekhar Karthik, Da Mesquita Sandro

Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation

年龄相关性黄斑变性和脑淀粉样血管病具有相似的病理机制,均源于胆固醇-APOE-β淀粉样蛋白-补体介导的炎症反应。

Stuard Sambhariya, Whitney; Bowes Rickman, Catherine; D'Amore, Patricia A; Corradetti, Giulia; Hageman, Gregory S; Howell, Gareth R; Marola, Olivia J; Phatnani, Hemali; Philp, Nancy J; Sinha, Debasish; Toomey, Christopher B; Stone, Faith; Eberhart, Charles; Handa, James T

Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer's Disease.

携带 APOE 的神经元细胞外囊泡下调丝状肌动蛋白聚合信号,从而抑制阿尔茨海默病中的突触形成。

APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

基于APOE分层的蛋白质组学和代谢组学分析揭示了阿尔茨海默病中的线粒体功能障碍、炎症和脂质代谢紊乱

Li, Fuhai; Chen, Yike; Western, Daniel; Ali, Muhammad; Liu, Menghan; Gong, Katherine; Xu, Ying; Lowery, Joseph; Holtzman, David M; Robins, Chloe; Eicher, John D; Huang, Yen-Ning; Liu, ShiWei; Park, Tamina; Saykin, Andrew J; Nho, Kwangsik; Moqri, Mahdi; Mohs, Richard C; Farinas, Amelia; Moran-Losada, Patricia; Oh, Hamilton Se-Hwee; Wyss-Coray, Tony; Cruchaga, Carlos

Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action.

巨噬细胞硬骨蛋白Loop2-ApoER2相互作用是硬骨蛋白发挥心血管保护作用所必需的。

Wang Luyao, Tao Xiaohui, Zhang Ning, Yang Xin, Jiang Hewen, Li Xiaofei, Wang Shenghang, Ding Shijian, Yu Sifan, Zhang Huarui, Zhang Yihao, Li Nanxi, Li Haitian, Li Zhanghao, Wen Xiaoxin, Sun Meiheng, Zhong Chuanxin, Liu Jin, Yu Yuanyuan, Luo Xianghang, Zhang Tao, Zhang Shu, Ferdinandy Péter, Huang Yu, Ma Daqing, Lu Aiping, Zhang Baoting, Zhang Ge

Why 11β-HSD1 inhibitors show variable efficacy in Alzheimer's therapy: an APOE4-dependent HSD11B1 mechanism.

为什么 11β-HSD1 抑制剂在阿尔茨海默病治疗中疗效不一:APOE4 依赖的 HSD11B1 机制。