日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

PVTX-405 的开发旨在将其作为一种高效且高选择性的 IKZF2 分子胶降解剂用于癌症免疫治疗。

Zhixiang Chen # ,Harshil Dhruv # ,Xuqing Zhang # ,Rohan Kalyan Rej # ,Longchuan Bai # ,Donna McEachern ,Paul Kirchhoff ,Rakesh Nagilla ,Larry J Jolivette ,Cory T Rice ,Peter Orth ,Corey O Strickland ,E Scott Priestley ,Helai P Mohammad ,Meilin Wang ,Bo Wen ,Duxin Sun ,Zhihua Sui ,Shaomeng Wang

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD

一种生殖系杂合显性负性IKZF2变异导致综合征性原发性免疫调节障碍和ICHAD

Henry Y Lu ,Maryam Vaseghi-Shanjani ,Avery J Lam ,Mehul Sharma ,Arezoo Mohajeri ,Leandro B R Silva ,Jana Gillies ,Gui Xiang Yang ,Susan Lin ,Maggie P Fu ,Areesha Salman ,Ronak Rahmanian ,Linlea Armstrong ,Jessica Halparin ,Connie L Yang ,Mark Chilvers ,Erika Henkelman ,Wingfield Rehmus ,Douglas Morrison ,Audi Setiadi ,Sara Mostafavi ,Michael S Kobor ,Frederick K Kozak ,Catherine M Biggs ,Clara van Karnebeek ,Kyla J Hildebrand ,Stuart E Turvey

Exome variant prioritization in a large cohort of hearing-impaired individuals indicates IKZF2 to be associated with non-syndromic hearing loss and guides future research of unsolved cases.

对大量听力障碍患者进行外显子组变异优先排序表明,IKZF2 与非综合征性听力损失相关,并指导未来对未解决病例的研究

Velde Hedwig M, Vaseghi-Shanjani Maryam, Smits Jeroen J, Ramakrishnan Gayatri, Oostrik Jaap, Wesdorp Mieke, Astuti Galuh, Yntema Helger G, Hoefsloot Lies, Lanting Cris P, Huynen Martijn A, Lehman Anna, Turvey Stuart E, Pennings Ronald J E, Kremer Hannie

Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells

双重 IKZF2 和 CK1α 降解剂靶向急性髓系白血病细胞

Sun-Mi Park ,David K Miyamoto ,Grace Y Q Han ,Mandy Chan ,Nicole M Curnutt ,Nathan L Tran ,Anthony Velleca ,Jun Hyun Kim ,Alexandra Schurer ,Kathryn Chang ,Wenqing Xu ,Michael G Kharas ,Christina M Woo

Omics-based integrated analysis identified IKZF2 as a biomarker associated with lupus nephritis

基于组学的综合分析发现 IKZF2 是与狼疮性肾炎相关的生物标志物。

Zhou, Mi; Kang, Yuening; Li, Jun; Li, Rongxiu; Lu, Liangjing

Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression

低剂量 IL-2 通过恢复慢性应激诱发的抑郁症小鼠模型中的 IL-6 与 TGF-β 之间以及 Th17 与 Treg 之间的平衡来减轻抑郁样行为和病理变化

Chengyi Huang, Fucheng Zhang, Peng Li, Cai Song

Do more with Less: Improving High Parameter Cytometry Through Overnight Staining

事半功倍:通过过夜染色提高高参数细胞计数

Carly E Whyte, Damon J Tumes, Adrian Liston, Oliver T Burton

Ikzf2 Regulates the Development of ICOS+ Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice

Ikzf2 调控 ICOS+ Th 细胞的发育,从而介导日本血吸虫感染的 C57BL/6 小鼠脾脏中的免疫反应

Shihao Xie,Haixia Wei,Anping Peng,Anqi Xie,Jiajie Li,Chao Fang,Feihu Shi,Quan Yang,He Huang,Hongyan Xie,Xingfei Pan,Xu Tian,Jun Huang

High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma

恶性T细胞中IKZF2的高表达促进皮肤T细胞淋巴瘤的疾病进展

Xu, Bufang; Liu, Fengjie; Gao, Yumei; Sun, Jingru; Li, Yingyi; Lin, Yuchieh; Liu, Xiangjun; Wen, Yujie; Yi, Shengguo; Dang, Jingyang; Tu, Ping; Wang, Yang

5-Aminoisoquinolinone, a PARP-1 Inhibitor, Ameliorates Immune Abnormalities through Upregulation of Anti-Inflammatory and Downregulation of Inflammatory Parameters in T Cells of BTBR Mouse Model of Autism

5-氨基异喹啉酮(一种PARP-1抑制剂)通过上调T细胞中的抗炎参数和下调炎症参数来改善BTBR自闭症小鼠模型的免疫异常

Khaled Alhosaini ,Mushtaq A Ansari ,Ahmed Nadeem ,Saleh A Bakheet ,Sabry M Attia ,Khalid Alhazzani ,Thamer H Albekairi ,Haneen A Al-Mazroua ,Hafiz M Mahmood ,Sheikh F Ahmad