日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IRAK4 Regulates NF-κB signaling to suppress CD8 + T cell activity and promote immune evasion in glioblastoma development

IRAK4通过调控NF-κB信号通路抑制CD8+T细胞活性,促进胶质母细胞瘤的免疫逃逸。

Xue, Zhaoliang; Song, Zhengfei; Mo, Lianjie; Shi, Lufeng; Yang, Shuxu

Examination of Noncanonical Kinase Hinge Binders Leads to Thiadiazoles as Potent IRAK4 Inhibitors

对非经典激酶铰链结合剂的研究发现噻二唑类化合物是强效的IRAK4抑制剂

Ammann, Stephen E; Brizgys, Gediminas; Ferrao, Ryan D; Wright, Nathan E; Mukherjee, Prasenjit Kumar; Bacon, Elizabeth M; Chin, Elbert; Chou, Chienhung; Cottell, Jeromy J; Hammond, Angela; Ndukwe, Marilyn S; Park, Grace Y; Shatskikh, Marina E; Suekawa-Pirrone, Kimberly; Warr, Matthew R; Yang, Zheng-Yu; Zipfel, Sheila M; Taylor, James G

Neuroimaging Findings and Treatment Update for Neuroinflammation, Autoinflammation, Splenomegaly, and Anemia, a Novel Autoinflammatory Disorder Caused by Bi-Allelic Variants in IRAK4

神经影像学发现及治疗进展:一种由IRAK4基因双等位基因变异引起的新型自身炎症性疾病——神经炎症、自身炎症、脾肿大和贫血

Price-Kuehne, Fiona; Avsenik, Jernej; Kaliakatsos, Marios; Brogan, Paul; Mankad, Kshitij

Design, synthesis and pharmacological evaluation of 3H-spiro[benzofuran-2,4'-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

3H-螺[苯并呋喃-2,4'-哌啶]IRAK4抑制剂的设计、合成及药理学评价及其在弥漫性大B细胞淋巴瘤治疗中的应用

Chen, Zhiwei; Zhang, Qi; Chen, Yun; Ning, Yi; Zhang, Q-I; Zhang, Mengxiao; Liu, Qiupei; Xue, Yi; Tong, Linjiang; Ding, Jian; Xie, Hua; Duan, Wenhu

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.

微生物三甲胺对 IRAK4 的抑制作用可减轻代谢炎症并改善血糖控制。

Chilloux Julien, Brial Francois, Everard Amandine, Smyth David, Andrikopoulos Petros, Zhang Liyong, Plovier Hubert, Myridakis Antonis, Hoyles Lesley, Moreno-Navarrete José Maria, Luque Jèssica Latorre, Casagrande Viviana, Menghini Rossella, Ahmetaj-Shala Blerina, Blancher Christine, Martinez-Gili Laura, Gencer Selin, Fearnside Jane F, Barton Richard H, Neves Ana Luisa, Rothwell Alice R, Gérard Christelle, Calderari Sophie, Williamson Mark J, Fuchs Julian E, Govada Lata, Boulangé Claire L, Patel Saroor, Scott James, Thursz Mark, Chayen Naomi, Glen Robert C, Gooderham Nigel J, Nicholson Jeremy K, Federici Massimo, Fernández-Real José Manuel, Gauguier Dominique, Liu Peter P, Cani Patrice D, Dumas Marc-Emmanuel

IRAK4: potential therapeutic target for airway disease exacerbations

IRAK4:气道疾病急性发作的潜在治疗靶点

Jude, Joseph A; Panettieri, Reynold A Jr

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization.

靶向 IRAK4 和 GSPT1 可通过 c-Myc 不稳定增强 AML 的治疗效果

Vick Eric J, Hassan Aishlin, Choi Kwangmin, Bennett Joshua, Muto Tomoya, Clough Courtnee A, Culver-Cochran Ashley E, Hueneman Kathleen, Bolanos Lyndsey C, Wunderlich Mark, Zhang Xiaohu, McKnight Crystal, Ceribelli Michele, Holland David, Klumpp-Thomas Carleen, Greis Kenneth D, Thomas Craig J, Starczynowski Daniel T

Smoking-Associated Carcinogen-Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation

吸烟相关致癌物诱导的炎症通过IRAK4激活促进肺癌发生

Ritesh K Aggarwal ,Simone Sidoli ,Jingli Wang ,Srabani Sahu ,Rahul Sanawar ,Varun Gupta ,Srinivas Aluri ,Vineeth Sukrithan ,Charan T R Vegivinti ,Phaedon D Zavras ,Divij Verma ,Shanisha Gordon-Mitchell ,Beamon Agarwal ,Tanya Verma ,Daniel T Starczynowski ,Ulrich G Steidl ,Aditi Shastri ,Balazs Halmos ,Lindsay M LaFave ,Haiying Cheng ,Amit Verma ,Yiyu Zou

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

调节IRAK4作为治疗单钠尿酸盐和黄嘌呤诱导的巨噬细胞和HepG2细胞炎症的策略

Umar, Sadiq; Chang, Huan T; Maienschein-Cline, Mark; Ravindran, Sriram

MUC1 alleviates PM2.5-induced airway inflammation by inhibiting the IRAK4/NF-κB/NLRP3 mediated pyroptosis in airway epithelial cells.

MUC1 通过抑制气道上皮细胞中 IRAK4/NF-κB/NLRP3 介导的细胞焦亡来减轻 PM2.5 引起的气道炎症。

Zhou You, Yang Kai, Wang Jian, Guan Ruijuan, Liu Wei, Wen Chaowei, Yuan Liang, Zhang Tiange, Feng Wei, Li Yuanyuan, Xu Jingyi, Lu Wenju