IRS1相关文献与解析，生知库 | 链接生命科学的每一步

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1-PI3K-AKT-GSK3β-GS Pathway in Insulin-Resistant Models

芥子碱通过IRS1-PI3K-AKT-GSK3β-GS通路调节胰岛素抵抗模型中的糖原和脂质合成

Xing, Tiancheng; Bai, Yiling; Wu, Weijie; Zhao, Ziqi; Kong, Hanyu; Zhang, Qianyi; Li, Shuoqi; Liu, Yan; Guo, Xiaohui; Wang, Zengli

IRS1

Shengdihuang Xiyangshen Zhimu Cangzhu Formula Improves Hepatic Glycogen Synthesis via the JNK/c-Jun/IRS1/GSK3Î² Signaling Pathway.

生地黄喜养神知母苍术方通过JNK/c-Jun/IRS1/GSK3β信号通路改善肝糖原合成。

期刊:Journal of Diabetes Research

影响因子:3.4

doi:10.1155/jdr/6019622

Qu Kewen, Li Mei, Sun Jinxu, Wu Shangping, Liu Xinyu, Liu Kanglin, Wu Shuxin, Guo Xiangyu

Gestational Diabetes and Genetics: MTNR1B, CDKAL1, and IRS1 as Critical Players

妊娠期糖尿病与遗传：MTNR1B、CDKAL1 和 IRS1 是关键因素

期刊:Genes

影响因子:2.8

doi:10.3390/genes17030287

Turan, Guluzar Arzu; Aran, Nehir; Delibasi, Bulent Tolga

Hispidulin: A potential antihyperglycemic and anti-oxidant agent-mechanistic insights into its modulatory effects on PI3K, AKT, mTOR, IRS1, GSK-3β, and GLUT-4 pathways through in vitro and in vivo studies

毛蕊花素：一种潜在的降血糖和抗氧化剂——通过体外和体内研究揭示其对PI3K、AKT、mTOR、IRS1、GSK-3β和GLUT-4通路调节作用的机制

期刊:Iranian Journal of Basic Medical Sciences

影响因子:2.7

doi:10.22038/ijbms.2025.88589.19136

Tariq, Muhammad Saad; Majeed, Wafa; Aslam, Bilal; Shahid, Muhammad

Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis.

源自癌症相关成纤维细胞的外泌体 miR-3126-5p 通过靶向 KLF13 激活 SH2B1/IRS1 轴来促进糖酵解，从而加速 NSCLC 的进展。

期刊:Clinical and Translational Medicine

影响因子:6.8

doi:10.1002/ctm2.70554

Zhang Zhenyu, Ma Haicheng, Zheng Yingying, Wang Lina, Wang Chenghui, Liu Yuanyuan, Lu Hengxiao, Wang Shaoqiang

Correction to: Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development

更正：雷公藤内酯醇通过调节 IRS1 表达来缓解卵巢衰老并促进卵泡发育

期刊:Cell Biology and Toxicology

影响因子:5.9

doi:10.1007/s10565-025-10107-6

Jiang, Yao; Shi, Yonghua; Lv, Meng; Wang, Tao; Wang, Penghao; Yuan, Xiaolong; Gao, Fei; Ma, Bin

Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity

胎盘IRS1 DNA甲基化与儿童肥胖的纵向分析

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26073141

Gómez-Vilarrubla, Ariadna; Niubó-Pallàs, Maria; Mas-Parés, Berta; Bonmatí-Santané, Alexandra; Martínez-Calcerrada, Jose-Maria; López, Beatriz; Peñas-Cruz, Aaron; de Zegher, Francis; Ibáñez, Lourdes; López-Bermejo, Abel; Bassols, Judit

Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway

来自石斛内生菌 Pseudomonas protegens CM-YJ44 的代谢产物通过 IRS1/PI3K/Akt/GSK3β/GLUT4 通路缓解 HepG2 细胞的胰岛素抵抗

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph18060817

Qin, Luqi; Zhou, Yixia; Fan, Bei; Zheng, Jiahuan; Diao, Rao; Liu, Jiameng; Wang, Fengzhong

Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway

雌二醇和维生素D通过miR-351-5p/IRS1轴和mTOR/NFκB信号通路对预防骨质疏松症发挥协同作用。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-02808-z

Dai, Xiaoyan; Liu, Changcun; Bi, Wenkai; Zheng, Guiwen; Lv, Kuan; Xia, Zhiming

LGALS3BP Induces Insulin Resistance via TLR2-IKKÎ±/Î² Pathway-Mediated IRS1 Serine Phosphorylation.

LGALS3BP 通过 TLR2-IKKα/β 通路介导的 IRS1 丝氨酸磷酸化诱导胰岛素抵抗。

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1-PI3K-AKT-GSK3β-GS Pathway in Insulin-Resistant Models

芥子碱通过IRS1-PI3K-AKT-GSK3β-GS通路调节胰岛素抵抗模型中的糖原和脂质合成

Shengdihuang Xiyangshen Zhimu Cangzhu Formula Improves Hepatic Glycogen Synthesis via the JNK/c-Jun/IRS1/GSK3Î² Signaling Pathway.

生地黄喜养神知母苍术方通过JNK/c-Jun/IRS1/GSK3β信号通路改善肝糖原合成。

Gestational Diabetes and Genetics: MTNR1B, CDKAL1, and IRS1 as Critical Players

妊娠期糖尿病与遗传：MTNR1B、CDKAL1 和 IRS1 是关键因素

Hispidulin: A potential antihyperglycemic and anti-oxidant agent-mechanistic insights into its modulatory effects on PI3K, AKT, mTOR, IRS1, GSK-3β, and GLUT-4 pathways through in vitro and in vivo studies

毛蕊花素：一种潜在的降血糖和抗氧化剂——通过体外和体内研究揭示其对PI3K、AKT、mTOR、IRS1、GSK-3β和GLUT-4通路调节作用的机制

Exosomal miR-3126-5p derived from cancer-associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis.

源自癌症相关成纤维细胞的外泌体 miR-3126-5p 通过靶向 KLF13 激活 SH2B1/IRS1 轴来促进糖酵解，从而加速 NSCLC 的进展。

Correction to: Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development

更正：雷公藤内酯醇通过调节 IRS1 表达来缓解卵巢衰老并促进卵泡发育

Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity

胎盘IRS1 DNA甲基化与儿童肥胖的纵向分析

Metabolites from the Dendrobium Endophyte Pseudomonas protegens CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway

来自石斛内生菌 Pseudomonas protegens CM-YJ44 的代谢产物通过 IRS1/PI3K/Akt/GSK3β/GLUT4 通路缓解 HepG2 细胞的胰岛素抵抗

Estradiol and vitamin D exert a synergistic effect on preventing osteoporosis via the miR-351-5p/IRS1 axis and mTOR/NFκB signaling pathway

雌二醇和维生素D通过miR-351-5p/IRS1轴和mTOR/NFκB信号通路对预防骨质疏松症发挥协同作用。