日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Jaye DL, Feldman AL. ALK-negative anaplastic large cell lymphoma with JAK2 rearrangement mimicking classic Hodgkin lymphoma. Blood. 2023;141(17):2160

Jaye DL, Feldman AL. ALK阴性间变性大细胞淋巴瘤伴JAK2重排，类似经典霍奇金淋巴瘤。Blood. 2023;141(17):2160

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2026033656
淋巴瘤
细胞生物学
JAK/STAT
ALK
JAK2
发表日期：2026
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A single JAK2-V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non-conditioned recipient mice

单个JAK2-V617F造血干细胞移植到未经预处理的受体小鼠体内即可诱发骨髓增生性肿瘤。

期刊:Hemasphere
影响因子:14.6
doi:10.1002/hem3.70359
Kimmerlin, Quentin; Hilpert, Morgane; Hansen, Nils; Guy, Alexandre; Usart, Marc; Stetka, Jan; Sobieralski, Patryk; Almeida Fonseca, Tiago; Hao-Shen, Hui; Skoda, Radek C
信号转导
细胞生物学
发育与干细胞
JAK/STAT
干细胞
肿瘤
肿瘤免疫
JAK2
发表日期：2026
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FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

FXYD3通过与IRF7结合调节JAK2/STAT5信号通路促进肝内胆管癌的肿瘤进展

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202510782
Zhou, Yan; Shen, Xiaofeng; Zhang, Shuo; Pu, XiaoHong; Xu, Zipeng; Zhao, Xiang; Feng, Wei; Liang, Yuan; He, Xingtao; Yang, Aihua; Qiu, Yudong; Yuan, Yihang; Chen, Chaobo; Chen, Jun
肿瘤
肿瘤免疫
JAK/STAT
信号转导
JAK2
胆管癌
发表日期：2026
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Targeting DESI2 as a Novel Therapeutic Strategy for JAK2-Mutant Leukemias

以DESI2为靶点治疗JAK2突变型白血病的新型治疗策略

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202515127
Mei, Husheng; Wen, Wuqiang; Zhang, Wenjun; Zhang, Shujing; Sun, Ting; Li, Guiming; Zhang, Jing; Qi, Shuang; Zhou, Jie; Li, Bing; Zhao, Yunshuo; Chen, Xiaotong; Li, Bowen; Xue, Yiying; Lu, Wang; Sun, Yanli; Wang, Jingyao; Shan, Hengyue; Zhang, Shengzhe; Huang, Yushan; Chen, Yisa; Wang, Wenchao; Liu, Qingsong; Lu, Wenchao; Tan, Li; Ding, Yi; Fu, Jianfei; Long, Jun; Zhang, Lei; Zhao, Baobing; Liang, Aibin; Jiang, Baishan; Yang, Jing
白血病
JAK/STAT
JAK2
发表日期：2026
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Tubule-Derived IFN-α Promotes GSDMD-Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation.

肾小管衍生的 IFN-α 促进 GSDMD 介导的巨噬细胞焦亡，通过 JAK2/STAT2 激活驱动肾脏炎症和纤维化。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202512278
Xu Yiping, Wang Yating, Jiang Siming, Li Yi, Li Guanglan, Liu Yuchu, Li Siyuan, Zhou Yiming, Liu Qinghua, Zhou Yi, Chen Wei, Li Hongyu, Mao Haiping
细胞生物学
巨噬细胞
TAT
DMD
JAK2
IFN-α
GSDMD
STAT2
Immunology/Inflammation
炎症
巨噬细胞
焦亡
发表日期：2026
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JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms

JAK2V617F 重编程缺氧诱导因子-1，从而在骨髓增生性肿瘤中诱导非经典缺氧调节子

期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-025-02843-9
Kealy, David; Ellerington, Ruth; Bansal, Suraj; Medeiros, Jessie J F; Hawley, Catherine A; Zeng, Andy G X; Lukaszonek, Jakub; West, Katie A; Sinha, Aparna D; Caalim, Gillian; Gawne, Richard T; Pope, Jacob; Ferreira, Bianca Lima; Blacknell, Nicole-Mae; Drylie, Bryce; Chatzigerou, Jenny; Khoo, Hwei Minn; Wilkinson, Adam C; Fielding, Adele K; Wang, Guanlin; Psaila, Bethan; Kent, David G; Hitchcock, Ian S; Holding, Andrew N; Mason, Andrew S; Gupta, Vikas; Dick, John E; Bridge, Katherine S
JAK/STAT
肿瘤
肿瘤免疫
JAK2
发表日期：2026
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NFκB/IL-6/JAK2/STAT axis in myelofibrosis is a key vulnerability that is targetable and relevant to JAK2 inhibitor treatment resistance

骨髓纤维化中的NFκB/IL-6/JAK2/STAT通路是一个关键的脆弱点，可作为靶点，并与JAK2抑制剂治疗耐药性相关。

期刊:Blood Cancer Journal
影响因子:11.6
doi:10.1038/s41408-025-01447-x
Bian, Huiqin; Gangat, Naseema; Shen, Na; Pang, Jiuxia; Wald, David; Tse, William; Tefferi, Ayalew; Yan, Fei; Liu, Shujun
JAK/STAT
信号转导
治疗耐药
JAK2
IL-6
发表日期：2026
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Curcumin reduces neuroinflammation and oxidative stress in a stroke model by epigenetically regulating ADRB2 methylation through JAK2/STAT3 and Nrf2/HO-1 pathways.

姜黄素通过 JAK2/STAT3 和 Nrf2/HO-1 通路，以表观遗传方式调节 ADRB2 甲基化，从而减轻中风模型中的神经炎症和氧化应激。

期刊:Journal of Neuroinflammation
影响因子:10.1
doi:10.1186/s12974-026-03729-y
Wei Liangzhe, Ren He, Zhao Mingyue, Xu Tianqi, Yang Jianhong, Deng Xinpeng, Sun Jie, Zhou Shengjun, Zhang Jianmin, Gao Xiang, Huang Yi
中风
炎症
表观遗传
氧化应激
炎症/感染
信号转导
JAK/STAT
心血管
神经科学
JAK2
STAT3
神经炎症
毒理研究
发表日期：2026
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Loss of Frmd5 Inhibits Jak2-Stat3 Signalling Pathway and Impairs Cell Apoptosis During Vagina Luminal Formation in Puberty Mice.

Frmd5 的缺失抑制了 Jak2-Stat3 信号通路，并损害了青春期小鼠阴道腔形成过程中的细胞凋亡。

期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.126669
Su Tiantian, Wang Zhenbin, Wu Yunjiao, Li Qianchen, Tian Li, Li Xiaowei, Zhang Jing, Yu Miao, Xing Yuqi, Du Juan, Zhao Lijun, Zhan Jun, Zhang Hongquan
细胞生物学
TAT
JAK2
STAT3
Apoptosis
凋亡
发表日期：2026
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The JAK2V617F and CALR mutations and risk of cancer, cardiovascular diseases, and all-cause mortality

JAK2V617F 和 CALR 突变与癌症、心血管疾病和全因死亡率风险的关系

期刊:Journal of Internal Medicine
影响因子:9.2
doi:10.1111/joim.70037
Larsen, Morten Kranker; Skov, Vibe; Kjær, Lasse; Eickhardt-Dalbøge, Christina Schjellerup; Knudsen, Trine Alma; Kristiansen, Marie Hvelplund; Sørensen, Anders Lindholm; Cordua, Sabrina; Wienecke, Troels; Jensen, Mette Grymer; Andersen, Morten; Ottesen, Johnny T; Gudmand-Høyer, Johanne; Snyder, Jordan Andrew; Poulsen, Henrik Enghusen; Stiehl, Thomas; Ellervik, Christina; Hasselbalch, Hans Carl
肿瘤
肿瘤免疫
JAK/STAT
心血管疾病
CALR
心血管
ALR
JAK2
发表日期：2026
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