KAT2A相关文献与解析，生知库 | 链接生命科学的每一步

Liu Ming, Vandekeere Anke, Liu Xiao-Zheng, Schenck Stephan, FernÃ¡ndez-GarcÃa Juan, Tricot Tine, Peng-Winkler Yiming, Demicco Margherita, Broekaert Dorien, Vermeire Ines, Theile Janine, Zels Gitte, Pabba Anirudh, Desmedt Christine, Brunner Janine D, Altea-Manzano Patricia, Fendt Sarah-Maria

乳腺癌

肿瘤

KAT2A

发表日期：2026

文献求助收藏

FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma

FOXM1通过影响DNA甲基化来增强KAT2A指导的TACC3选择性剪接，从而在肝细胞癌中发挥作用。

期刊:Clinical and Molecular Hepatology

影响因子:16.9

doi:10.3350/cmh.2025.1370

Zhao, Li Na; Andersen, Jesper B

Disruption of the SAGA CORE triggers collateral degradation of KAT2A.

SAGA CORE 的破坏会引发 KAT2A 的附带退化。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-026-71613-7

Batty Paul, Beneder Hannah, SchÃ¤tz Caroline, Onea Gabriel, Zaczek Maciej, Kutschat Ana P, Abele Miriam, MÃ¼ller Sophie, Superti-Furga Giulio, Winter Georg E, Seruggia Davide

KAT2A

发表日期：2026

文献求助收藏

The mechanism by which KAT2A increases the stability of CDC25A through acetylation to regulate glycolysis and mediate lung adenocarcinoma immune escape.

KAT2A 通过乙酰化作用增加 CDC25A 的稳定性，从而调节糖酵解并介导肺腺癌免疫逃逸的机制。

期刊:Respiratory Research

影响因子:5

doi:10.1186/s12931-026-03544-2

Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma

卡博替尼与DHRS2-KAT2A-H3K27ac轴驱动的铜凋亡诱导在透明细胞肾细胞癌中具有协同抗癌作用

期刊:Biology Direct

影响因子:4.9

doi:10.1186/s13062-025-00721-z

Cao, Yilong; Xu, Chao; Zhang, Bowei; Qu, Changbao; Liu, Yuepeng; Shi, Bei; Li, Xiaoling; Li, Jiehan; Zhang, Zeyuan; Dai, Shengtao; Sun, Qingyun; Wang, Yaxuan; Gu, Junfei

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation.

KAT2A 缺陷通过降低 MYC 琥珀酰化作用下调 MYC，从而抑制肺癌进展。

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.70286

Li Junping, Zhao Feng, Wang Zhongchao, Yang Shaojun, Lu Zhichao, Li Xiaoyan, Song Jincheng, Dai Zhaoxia

Correction: SF3B4 downregulation restrains lung adenocarcinoma tumorigenesis via 5' alternative splicing of KAT2A

更正：SF3B4 下调通过 KAT2A 的 5' 端选择性剪接抑制肺腺癌的肿瘤发生

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-33009-3

Qu, Ailin; Han, Bo; Hua, Mengmeng; Wang, Chune; Li, Tao

In vitro experiments and bioinformatic analyses implicate KAT2A in the occurrence and development of hepatocellular carcinoma

体外实验和生物信息学分析表明，KAT2A与肝细胞癌的发生和发展有关。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-36174-1

Xu, Zhen-Yue; Tan, Jian-Hui; Li, Jia-Xing; Huang, Shi-Wei; Xu, Jun-Er; Zhong, Guo-Hui; Zhai, Jing-Wei; Tan, Xiao-Yu; Liu, Guo-Hua

HOXA5 Suppresses NEK7-Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

HOXA5通过转录抑制KAT2A来抑制急性肺损伤中NEK7介导的肺泡上皮细胞焦亡

期刊:Kaohsiung Journal of Medical Sciences

影响因子:2.7

doi:10.1002/kjm2.70109.

Lei Wang,Heng Fan,Qi Wang,Cheng-Jie Jiang,Dan-Hui Li,Ji-Hui Ye

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

KAT2A驱动的SRSF11琥珀酰化增强剪接体介导的RAD52剪接，从而促进肝细胞癌中的同源重组和放射抗性。

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-025-02458-7

Wu, Jun; Yuan, Jingsheng; Liu, Zijian; Zhou, Yongjie; Zhang, Bo; Xu, Yahong; Zeng, Qiwen; Wu, Zhenru; Kong, Lingxiang; Wang, Jiaguo; Zhang, Bohan; Yang, Jian; Lv, Tao; Shi, Yujun; Yang, Jiayin

Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer.

棕榈酰化介导的 KAT2A 调控促进乳腺癌肺转移。

FOXM1 influences DNA methylation to augment TACC3 alternative splicing directed by KAT2A in hepatocellular carcinoma

FOXM1通过影响DNA甲基化来增强KAT2A指导的TACC3选择性剪接，从而在肝细胞癌中发挥作用。

Disruption of the SAGA CORE triggers collateral degradation of KAT2A.

SAGA CORE 的破坏会引发 KAT2A 的附带退化。

The mechanism by which KAT2A increases the stability of CDC25A through acetylation to regulate glycolysis and mediate lung adenocarcinoma immune escape.

KAT2A 通过乙酰化作用增加 CDC25A 的稳定性，从而调节糖酵解并介导肺腺癌免疫逃逸的机制。

Synergistic anticancer effects of cabozantinib and cuproptosis induction driven by DHRS2-KAT2A-H3K27ac axis in clear cell renal cell carcinoma

卡博替尼与DHRS2-KAT2A-H3K27ac轴驱动的铜凋亡诱导在透明细胞肾细胞癌中具有协同抗癌作用

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation.

KAT2A 缺陷通过降低 MYC 琥珀酰化作用下调 MYC，从而抑制肺癌进展。

Correction: SF3B4 downregulation restrains lung adenocarcinoma tumorigenesis via 5' alternative splicing of KAT2A

更正：SF3B4 下调通过 KAT2A 的 5' 端选择性剪接抑制肺腺癌的肿瘤发生

In vitro experiments and bioinformatic analyses implicate KAT2A in the occurrence and development of hepatocellular carcinoma

体外实验和生物信息学分析表明，KAT2A与肝细胞癌的发生和发展有关。

HOXA5 Suppresses NEK7-Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

HOXA5通过转录抑制KAT2A来抑制急性肺损伤中NEK7介导的肺泡上皮细胞焦亡

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

KAT2A驱动的SRSF11琥珀酰化增强剪接体介导的RAD52剪接，从而促进肝细胞癌中的同源重组和放射抗性。