日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes

性别特异性的KDM6A-HNF4A-CREBH网络通过肝细胞的表观遗传重编程控制脂蛋白胆固醇代谢和动脉粥样硬化

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-70846-w
Chen, Lin; Kang, Zhanfang; Härdfeldt, Jennifer; Li, Ziyi; Pedrelli, Matteo; Li, Qi; Lyu, Ruining; Valina Allo, Philipp; Sych, Taras; Zheng, Xiangru; Lin, Peibin; Zeng, Jianwen; Huang, Zhiqiang; Garcia-Irigoyen, Oihane; Sukhanava, Sviatlana; Parini, Paolo; Bonnefond, Amélie; Sezgin, Erdinc; Angelin, Bo; Treuter, Eckardt; Fan, Rongrong
心血管
代谢
细胞生物学
表观遗传
CREB
KDM6A
动脉粥样硬化
发表日期：2026
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Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer

KDM6A介导的基因组不稳定性丧失和代谢重编程调节膀胱癌对治疗扰动的反应

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-68132-2
Singh, Pratishtha; D'Rozario, Ranit; Chakraborty, Bidisha; Meher, Swadhin; Raychaudhuri, Deblina; Tannir, Aminah J; Li, Yang; Majumdar, Anurag; Hawkins, Jessalyn; Xiong, Yun; Lorenzi, Philip; Sharma, Padmanee; Akdemir, Kadir; Pilie, Patrick; Jain, Abhinav K; Lee, Byron Hing Lung; Goswami, Sangeeta
肿瘤
肿瘤免疫
代谢
KDM6A
代谢重编程
膀胱癌
发表日期：2026
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Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

USP7 和 RNF40 的拮抗性泛素转换调控 KDM6A 稳态，从而导致冠状病毒易感性

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202518058
Huang, Meng-Zhuo; Yang, Zhong-Yuan; Wang, Shi; Ge, Yan; Lin, Lan; Alfajaro, Mia Madel; Filler, Renata B; Song, Wan-Yao; Kong, Ming-Zhu; Wei, Jin
微生物学
信号转导
SP7
KDM6A
发表日期：2026
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EZH2 suppresses IR-induced ferroptosis by forming a co-repressor complex with HIF-1α to inhibit ACSL4: Targeting EZH2 enhances radiosensitivity in KDM6A-deficient esophageal squamous carcinoma

EZH2通过与HIF-1α形成共抑制复合物来抑制ACSL4，从而抑制IR诱导的铁死亡：靶向EZH2可增强KDM6A缺陷型食管鳞状细胞癌的放射敏感性

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01451-5
Pan, Guizhen; Xia, Yeye; Hao, Mengyu; Guan, Jiahao; Zhu, Qianqian; Zha, Tianqi; Sheng, Lei; Zhao, Zhenfeng; Pan, Huaguang; Fang, Weiyang; Xu, Xiaoyong; Chen, Xiangcun; Zhou, Shuguang; Tong, Zhuting
肿瘤
肿瘤免疫
ACSL4
铁死亡
KDM6A
EZH2
细胞生物学
发表日期：2025
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KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers

KDM6A下调通过激活增强子促进癌相关成纤维细胞中肿瘤易感细胞因子的表达。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07818-3
Zhang, Jieying; Xiang, Suoyu; Liu, Dan; Pei, Xiaomeng; Chen, Meng; Zhao, Yiheng; Wang, Yongbin; Wang, Qiong; Kang, Lan; Yu, Zuoren; Mi, Jun; Xiong, Wujun
成纤维细胞
肿瘤
肿瘤免疫
KDM6A
细胞生物学
免疫/内分泌
发表日期：2025
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KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC

KDM6A磷酸化抑制PER2，从而导致头颈部鳞状细胞癌（HNSCC）中糖酵解脆弱性。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08130-w
Chen, Jun; Ji, Yikang; Chen, Xin; Zhang, Mi; Zhang, Mei; Hu, Xin; Xu, Xing; Zhang, Yu; Zhang, Zhen; Pan, Xinhua; Yan, Ming; Zhang, Jianjun; Xu, Qin; Yang, Xi; Chen, Wantao; Wang, Xu
肿瘤
肿瘤免疫
信号转导
KDM6A
磷酸化
细胞生物学
PER2
发表日期：2025
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The RNF8/OPTN/KDM6A axis controls macrophage polarization to maintain testicular microenvironment homeostasis

RNF8/OPTN/KDM6A轴控制巨噬细胞极化以维持睾丸微环境稳态

期刊:Cell Death Discovery
影响因子:6.1
doi:10.1038/s41420-025-02641-3
Yanan Guo ,Peng Xia ,Yixiao Tian ,Daosen Fu ,Xiaohui Hu ,Kun Xie ,Wenhao Dong ,Wei Zhang ,Disheng Liu ,Rong Shen ,Degui Wang
PTN
RNF8
巨噬细胞
细胞生物学
巨噬细胞
KDM6A
免疫/内分泌
发表日期：2025
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Congenital Hyperinsulinism and Novel KDM6A Duplications -Resolving Pathogenicity With Genome and Epigenetic Analyses

先天性高胰岛素血症和新型KDM6A重复——利用基因组和表观遗传分析解析其致病性

期刊:Journal of Clinical Endocrinology & Metabolism
影响因子:5.1
doi:10.1210/clinem/dgae524
Männistö, Jonna M E; Hopkins, Jasmin J; Hewat, Thomas I; Nasser, Fatima; Burrage, Joseph; Dastamani, Antonia; Mirante, Alice; Murphy, Nuala; Rzasa, Jessica; Kerkhof, Jennifer; Relator, Raissa; Johnson, Matthew B; Laver, Thomas W; Weymouth, Luke; Houghton, Jayne A L; Wakeling, Matthew N; Sadikovic, Bekim; Dempster, Emma L; Flanagan, Sarah E
KDM6A
表观遗传
免疫/内分泌
发表日期：2025
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KDM6A facilitates Xist upregulation at the onset of X inactivation

KDM6A促进X染色体失活开始时Xist的上调

期刊:Biology of Sex Differences
影响因子:5.1
doi:10.1186/s13293-024-00683-3
Lin, Josephine; Zhang, Jinli; Ma, Li; Fang, He; Ma, Rui; Groneck, Camille; Filippova, Galina N; Deng, Xinxian; Kinoshita, Chizuru; Young, Jessica E; Ma, Wenxiu; Disteche, Christine M; Berletch, Joel B
KDM6A
发表日期：2025
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Multi-omics elucidation of KDM5C, KDM6A, and KMT2B roles in cancer epigenetic dysregulation and transcriptional reprogramming.

多组学阐明 KDM5C、KDM6A 和 KMT2B 在癌症表观遗传失调和转录重编程中的作用。

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-09305-z
Li Tengjiao, Wang Lichen, Duan Shoufeng, Cui Xinyu, Fu Chunqing, Hu Jinglei, Li Lin
肿瘤
KDM6A
KMT2B
m6A/m5C/m7G
发表日期：2025
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