KLF4相关文献与解析，生知库 | 链接生命科学的每一步

TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling.

TRIM56 通过抑制 KLF4 激活的铁死亡信号通路加剧脑缺血再灌注损伤。

doi:10.1002/advs.202509906

Wang Qiangping, Li Shuang, Li Man, Zhou Wenke, Zhang Jianqing, Wu Zhenfu, Mao Zhaoqi, Wan Juan, Tang Xinhao, Zheng Baoping, Liu Qiang, Li Zhendong, Jiang Xiaobing, Wu Qingping, Ye Youfan, Wang Haijun

The KLF4-CD46 axis: a novel therapeutic target in transplant-associated thrombotic microangiopathy and beyond

KLF4-CD46轴：移植相关血栓性微血管病及其他疾病的新型治疗靶点

期刊:Haematologica

影响因子:7.9

doi:10.3324/haematol.2025.288680

Cugno, Massimo; Lämmle, Bernhard

KLF4 overexpression protects against complementmediated endothelial injury in transplant-associated thrombotic microangiopathy

KLF4 过表达可保护移植相关血栓性微血管病中的内皮细胞免受补体介导的损伤。

期刊:Haematologica

影响因子:7.9

doi:10.3324/haematol.2025.287676

Jiang, Shuhui; Qi, Jiaqian; Pan, Tingting; Yao, Zhenzhen; Lu, Siyi; Han, Yifei; Wu, Depei; Han, Yue

AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma

AXL是MEK抑制剂治疗的黑色素瘤中一种新型的ERK5/KLF4靶点。

期刊:Neoplasia

影响因子:7.7

doi:10.1016/j.neo.2026.101301

Paudel, Rupesh; Goller, Simon; Schwarz, Stefanie; Meder, Katharina; Goebeler, Matthias; Schmidt, Marc

TGF-Î²1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.

TGF-β1/SMAD 信号通过直接转录抑制和 FAT10 介导的蛋白酶体降解来下调肝细胞癌中的 KLF4 表达。

期刊:Cell and Bioscience

影响因子:6.2

doi:10.1186/s13578-025-01524-5

Retraction: The intra-nuclear SphK2-S1P axis facilitates M1-to-M2 shift of microglia via suppressing HDAC1-mediated KLF4 deacetylation

撤回：核内SphK2-S1P轴通过抑制HDAC1介导的KLF4去乙酰化促进小胶质细胞从M1型向M2型转变

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1809852

Xinfeng capsule improves hyperinflammation-associated hypercoagulability and self-perception in osteoarthritis by regulating KLF4 through METTL14-mediated m(6)A modification of lncRNA MEG3

欣丰胶囊通过METTL14介导的lncRNA MEG3的m(6)A修饰调节KLF4，从而改善骨关节炎中与高炎症相关的血液高凝状态和自我感知。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1749727

He, Mingyu; Liu, Jian; Sun, Yanqiu; Fang, Yanyan; Wang, Fanfan

Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota-pyroptosis-barrier axis of ulcerative colitis

整合孟德尔随机化和实验验证将KLF4在溃疡性结肠炎的肠道菌群-细胞焦亡-屏障轴中置于优先位置

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1773990

Zhu, Wenya; Jin, Xiaoxu; Guo, Xiaofeng; Gao, Xin

KCTD15 Enhances Stem Cell-Like Properties and Promotes Triple-Negative Breast Cancer Progression Through KLF4/Î²-Catenin Signaling.

KCTD15 通过 KLF4/β-catenin 信号通路增强干细胞样特性并促进三阴性乳腺癌进展。

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.202503381R

Yao Liang, Sun Wei, Xing Jun, Feng Jing

Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression

两个CCM2分子同时募集至KRIT1可抑制KLF4表达

TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling.

TRIM56 通过抑制 KLF4 激活的铁死亡信号通路加剧脑缺血再灌注损伤。

The KLF4-CD46 axis: a novel therapeutic target in transplant-associated thrombotic microangiopathy and beyond

KLF4-CD46轴：移植相关血栓性微血管病及其他疾病的新型治疗靶点

KLF4 overexpression protects against complementmediated endothelial injury in transplant-associated thrombotic microangiopathy

KLF4 过表达可保护移植相关血栓性微血管病中的内皮细胞免受补体介导的损伤。

AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma

AXL是MEK抑制剂治疗的黑色素瘤中一种新型的ERK5/KLF4靶点。

TGF-Î²1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma.

TGF-β1/SMAD 信号通过直接转录抑制和 FAT10 介导的蛋白酶体降解来下调肝细胞癌中的 KLF4 表达。

Retraction: The intra-nuclear SphK2-S1P axis facilitates M1-to-M2 shift of microglia via suppressing HDAC1-mediated KLF4 deacetylation

撤回：核内SphK2-S1P轴通过抑制HDAC1介导的KLF4去乙酰化促进小胶质细胞从M1型向M2型转变

Xinfeng capsule improves hyperinflammation-associated hypercoagulability and self-perception in osteoarthritis by regulating KLF4 through METTL14-mediated m(6)A modification of lncRNA MEG3

欣丰胶囊通过METTL14介导的lncRNA MEG3的m(6)A修饰调节KLF4，从而改善骨关节炎中与高炎症相关的血液高凝状态和自我感知。

Integrative Mendelian randomization and experimental validation prioritize KLF4 in the gut microbiota-pyroptosis-barrier axis of ulcerative colitis

整合孟德尔随机化和实验验证将KLF4在溃疡性结肠炎的肠道菌群-细胞焦亡-屏障轴中置于优先位置

KCTD15 Enhances Stem Cell-Like Properties and Promotes Triple-Negative Breast Cancer Progression Through KLF4/Î²-Catenin Signaling.

KCTD15 通过 KLF4/β-catenin 信号通路增强干细胞样特性并促进三阴性乳腺癌进展。