日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Olive Leaf Extract Added to Losartan Treatment Improved Klotho/Wnt/β-Catenin Signaling in Hypertensive Rats with Focal Segmental Glomerulosclerosis.

在患有局灶节段性肾小球硬化症的高血压大鼠中，添加橄榄叶提取物可改善 Klotho/Wnt/β-catenin 信号传导。

期刊:Antioxidants
影响因子:6.6
doi:10.3390/antiox15010146
Karanović Danijela, Mihailović-Stanojević Nevena, Ivanov Milan, Vujačić Una-Jovana, Grujić-Milanović Jelica, Životić Maja, Dekanski Dragana, Jovović Djurdjica, Miloradović Zoran
高血压
信号转导
KLOT
发表日期：2026
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Sex-Related Expression of Klotho in Rat Kidneys: Species Differences Between Rats and Mice.

大鼠肾脏中 Klotho 的性别相关表达：大鼠和小鼠之间的物种差异。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27020716
KLOT
发表日期：2026
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Maternal and neonatal vitamin D metabolite profiling and its long-term impact on childhood growth: findings from the KLOTHO birth cohort

母体和新生儿维生素D代谢物谱及其对儿童生长发育的长期影响：来自KLOTHO出生队列的研究结果

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2026.1772187
Karras, Spyridon N; Kypraiou, Maria; Harizopoulou, Vikentia; Vlastos, Antonios; Anemoulis, Marios; Dalamaga, Maria; Georgopoulos, Neoklis; Kassi, Evanthia; Mastorakos, Georgios; Makedou, Kali; Skoutas, Dimitrios; Peppa, Melpomeni; Goulis, Dimitrios G
发育与干细胞
KLOT
代谢
发表日期：2026
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Uremic toxin p‑cresyl sulfate enhances the calcification of aortic valvular interstitial cells via klotho/sirtuin‑1 signaling.

尿毒症毒素对甲酚硫酸盐通过 Klotho/Sirtuin 1 信号通路增强主动脉瓣间质细胞的钙化。

期刊:Molecular Medicine Reports
影响因子:3.5
doi:10.3892/mmr.2026.13872
Li Shao-Jung, Cheng Tzu-Yu, Kao Yu-Hsun, Chen Wei-Yu, Chung Cheng-Chih, Trang Nguyen Ngoc, Chen Pao-Huan, Chen Yi-Jen
细胞生物学
KLOT
发表日期：2026
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KLOTHO-VS heterozygosity, α-klotho protein levels and cognitive performance in Alzheimer's disease

KLOTHO-VS杂合性、α-klotho蛋白水平与阿尔茨海默病患者的认知功能

期刊:Alzheimers Research & Therapy
影响因子:7.6
doi:10.1186/s13195-025-01878-5
Katonova, Alzbeta; Andel, Ross; Jurasova, Vanesa; Veverova, Katerina; Borovska, Sarka; Horakova, Hana; Kolarova, Tereza; Matoska, Vaclav; Vyhnalek, Martin; Hort, Jakub
阿尔茨海默症
KLOT
神经科学
发表日期：2025
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Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine.

Klotho-Sirt1通路调控心脏、肾脏和小肠中的干细胞衰老和细胞增殖。

期刊:NPJ Aging
影响因子:6
doi:10.1038/s41514-025-00286-1
Dai Dao-Fu, Daneshgar Nastaran, Wang Kaihao, Liang Pei-Ing, Bosch Dustin, Grueter Chad
衰老
发育与干细胞
干细胞
KLOT
SirT1
细胞衰老
发表日期：2025
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Reduced Circulating α-Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries.

循环中α-Klotho水平降低与死亡率升高以及主动脉和髂动脉钙化有关。

期刊:Journal of the American Heart Association
影响因子:5.3
doi:10.1161/JAHA.125.043654
Hellou Elias, Kalhor Parvin, Babaie Ali, Akhiyat Nadia, Hamidabad Negin Mahmoudi, Nardi Valentina, Manzato Matteo, Nogami Kai, Copley Elizabeth, Lerman Lilach O, Lerman Amir
KLOT
发表日期：2025
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The KLOTHO Birth Cohort: Maternal and Neonatal Vitamin D Status and Neurodevelopmental Outcomes at 10 Years

KLOTHO出生队列：母婴维生素D水平与10岁时的神经发育结果

期刊:Nutrients
影响因子:5
doi:10.3390/nu18010076
Karras, Spyridon N; Goulis, Dimitrios G; Kypraiou, Maria; Harizopoulou, Vikentia; Vlastos, Antonios; Anemoulis, Marios; Tzimagiorgis, Georgios; Dalamaga, Maria; Georgopoulos, Neoklis; Kassi, Evanthia; Mastorakos, Georgios; Makedou, Kali; Skoutas, Dimitrios; Michalakis, Konstantinos G
发育与干细胞
KLOT
神经科学
发表日期：2025
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α-Klotho Supplementation Mitigates Cumulative Exercise-Induced Fatigue via Coordinated NRF2-Mediated Antioxidant Defense and AKT/GS-Driven Hepatic Glycogen Supercompensation in Mice.

α-Klotho 补充剂通过协调 NRF2 介导的抗氧化防御和 AKT/GS 驱动的肝糖原超量补偿来减轻小鼠累积性运动引起的疲劳。

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27010412
AKT
NRF2
KLOT
PI3K/Akt
发表日期：2025
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The anti-aging Klotho protects glioblastoma macrophages from radiotherapy-induced inflammation and predicts immunotherapy response.

抗衰老 Klotho 可保护胶质母细胞瘤巨噬细胞免受放射治疗引起的炎症，并预测免疫治疗反应。

期刊:International Journal of Cancer
影响因子:4.7
doi:10.1002/ijc.70038
Galluzzo Andrea, Maffezzini Martina, Fumagalli Maria Luisa, Sambruni Irene, Musio Silvia, Patanè Monica, Paterra Rosina, Salvi Erika, Facciolla Manuel, Milani Micaela, Schiariti Marco, Mattei Luca, Rossi Alessandra, Eoli Marica, Poliani Luigi, Silvani Antonio, Pollo Bianca, Fariselli Laura, Di Ianni Natalia, Pellegatta Serena
衰老
细胞生物学
巨噬细胞
KLOT
Immunology/Inflammation
炎症
巨噬细胞
发表日期：2025
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