Ku70相关文献与解析，生知库 | 链接生命科学的每一步

Liang, Xueyi; Zhao, Jingyuan; Li, Shoukang; Wei, Ruozheng; Yu, Haixin; Zhang, Qiyue; Fu, Qixun; Qin, Gengdu; Zhao, Yuhan; Liu, Jiaying; Liu, Zhiqiang; Peng, Tao; Meng, Junpeng; Gou, Shanmiao; Yin, Tao; Wu, Heshui; Wang, Bo; Zhou, Yingke

乙酰化

Ku70

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HDAC5

发表日期：2026

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Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

Ku70的非经典作用通过FOXP3依赖性机制促进肺腺癌中Treg细胞的抑制功能

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI191305

Huang, Qianru; Tian, Na; Zhang, Jianfeng; Song, Shiyang; Cheng, Hao; Liu, Xinnan; Zhang, Wenle; Ye, Youqiong; Du, Yanhua; Dai, Xueyu; Liang, Rui; Li, Dan; Dai, Sheng-Ming; Wang, Chuan; Chen, Zhi; Zhou, Qianjun; Li, Bin

Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington's disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption

寨卡病毒通过突变亨廷顿蛋白诱导的Ku70/Ku80复合物破坏，损害亨廷顿病iPSCs来源的神经祖细胞中的非同源末端连接，并加剧DNA损伤。

期刊:Stem Cell Research & Therapy

影响因子:7.3

doi:10.1186/s13287-025-04539-4

Chiu, Feng-Lan; Liang, Jian-Jong; Lin, Yi-Ling; Kuo, Hung-Chih

High-Frequency Generation of Homozygous/Biallelic Mutants via CRISPR/Cas9 Driven by AtKu70/80 Promoters

利用AtKu70/80启动子驱动的CRISPR/Cas9技术高频生成纯合/双等位基因突变体

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26189094

Zhang, Huihui; Teng, Chong; Lyu, Shanhua; Fan, Yinglun

Ku70

发表日期：2025

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Airborne PM(10) Decreases Ku80 Expression and Ku70-Ku80 Heterodimer Levels of the Non-Homologous End Joining Repair Pathway in Lung Epithelial Cells

空气中的PM(10)降低肺上皮细胞中非同源末端连接修复途径的Ku80表达和Ku70-Ku80异二聚体水平

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms26188936

Quezada-Maldonado, Ericka Marel; Lozolla-Ortiz, Javier Ivan; Santibáñez-Andrade, Miguel; Morales-Bárcenas, Rocío; García-Cuellar, Claudia M; Sánchez-Pérez, Yesennia

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF-dependent activation of hypoxia-inducible genes.

TFAP2A 与 Ku70/80 复合物的相互作用对于 HIF 依赖性缺氧诱导基因的激活至关重要。

期刊:FEBS Journal

影响因子:4.2

doi:10.1111/febs.70025

Design, synthesis, and structure-activity relationship studies of 4-substituted phenylpyrazolidinone derivatives as potent Ku70/80 targeted DNA-PK inhibitors

4-取代苯基吡唑烷酮衍生物作为强效Ku70/80靶向DNA-PK抑制剂的设计、合成及构效关系研究

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d5md00263j

Kushwaha, Narva Deshwar; VanderVere-Carozza, Pamela; Vernon, Tyler L; Mendoza-Munoz, Pamela L; Gaddameedi, Jitender D; Ben Ali Gacem, Karim; Engel, Joseph; Charbonnier, Jean-Baptiste; Gavande, Navnath S; Turchi, John J

Ku70

发表日期：2025

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Canine Ku70 requires binding between its nuclear localization signal and nuclear pore-targeting complex for nuclear localization

犬类Ku70蛋白需要其核定位信号与核孔靶向复合物结合才能进行核定位。

期刊:Journal of Veterinary Medical Science

影响因子:1.1

doi:10.1292/jvms.25-0023

Koike, Manabu; Ikuta, Togo; Koike, Aki

m(6)A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma

m(6)A介导的lnc-OXAR通过增强Ku70稳定性促进非酒精性脂肪性肝炎相关肝细胞癌的奥沙利铂耐药性

期刊:Journal of Experimental & Clinical Cancer Research

影响因子:12.8

doi:10.1186/s13046-024-03134-4

Lin, Zhu; Huang, Zhenkun; Qiu, Jiliang; Shi, Yunxing; Zuo, Dinglan; Qiu, Zhiyu; He, Wei; Niu, Yi; Yuan, Yunfei; Li, Binkui

Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response

核豪猪介导 DNA 损伤反应中的 XRCC6/Ku70 S-棕榈酰化

期刊:Experimental Hematology & Oncology

影响因子:9.4

doi:10.1186/s40164-024-00572-w

Yang Chen #, Mingming Xiao #, Yaqi Mo #, Jinlu Ma #, Yamei Han, Qing Li, Qinghua Zeng, Rebecca J Boohaker, Joshua Fried, Yonghe Li, Han Wang, Bo Xu

Ku70

发表日期：2024

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CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation

CK2介导的HDAC5穿梭通过Ku70去乙酰化调节DNA末端切除

Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

Ku70的非经典作用通过FOXP3依赖性机制促进肺腺癌中Treg细胞的抑制功能

Zika virus impairs non-homologous end joining and exacerbates DNA damage in neural progenitors derived from Huntington's disease iPSCs via mutant huntingtin-elicited Ku70/Ku80 complex disruption

寨卡病毒通过突变亨廷顿蛋白诱导的Ku70/Ku80复合物破坏，损害亨廷顿病iPSCs来源的神经祖细胞中的非同源末端连接，并加剧DNA损伤。

High-Frequency Generation of Homozygous/Biallelic Mutants via CRISPR/Cas9 Driven by AtKu70/80 Promoters

利用AtKu70/80启动子驱动的CRISPR/Cas9技术高频生成纯合/双等位基因突变体

Airborne PM(10) Decreases Ku80 Expression and Ku70-Ku80 Heterodimer Levels of the Non-Homologous End Joining Repair Pathway in Lung Epithelial Cells

空气中的PM(10)降低肺上皮细胞中非同源末端连接修复途径的Ku80表达和Ku70-Ku80异二聚体水平

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF-dependent activation of hypoxia-inducible genes.

TFAP2A 与 Ku70/80 复合物的相互作用对于 HIF 依赖性缺氧诱导基因的激活至关重要。

Design, synthesis, and structure-activity relationship studies of 4-substituted phenylpyrazolidinone derivatives as potent Ku70/80 targeted DNA-PK inhibitors

4-取代苯基吡唑烷酮衍生物作为强效Ku70/80靶向DNA-PK抑制剂的设计、合成及构效关系研究

Canine Ku70 requires binding between its nuclear localization signal and nuclear pore-targeting complex for nuclear localization

犬类Ku70蛋白需要其核定位信号与核孔靶向复合物结合才能进行核定位。

m(6)A-mediated lnc-OXAR promotes oxaliplatin resistance by enhancing Ku70 stability in non-alcoholic steatohepatitis-related hepatocellular carcinoma

m(6)A介导的lnc-OXAR通过增强Ku70稳定性促进非酒精性脂肪性肝炎相关肝细胞癌的奥沙利铂耐药性

Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response

核豪猪介导 DNA 损伤反应中的 XRCC6/Ku70 S-棕榈酰化