日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR.

家族性高胆固醇血症基因 LDLR 编码变异的功能图谱。

Tabet Daniel R, Coté Atina G, Lancaster Megan C, Weile Jochen, Rayhan Ashyad, Fotiadou Iosifina, Kishore Nishka, Li Roujia, Kuang Da, Knapp Jennifer J, Carrero Carmela S, Taverniti Olivia, Axakova Anna, Castelli Jack M P, Islam Mohammad M, Sowlati-Hashjin Shahin, Gandhi Aanshi, Maaieh Ranim, Garton Michael, Matreyek Kenneth, Fowler Douglas M, Bourbon Mafalda, Pfisterer Simon G, Glazer Andrew M, Kroncke Brett M, Parikh Victoria N, Ashley Euan A, Knowles Joshua W, Claussnitzer Melina, Cirulli Elizabeth T, Hegele Robert A, Roden Dan M, MacRae Calum A, Roth Frederick P

The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus.

低密度脂蛋白受体 LDLR 介导无包膜甲型肝炎病毒进入细胞。

Shiota Tomoyuki, Zhao Yuguang, Shiota Itoe, Duyvesteyn Helen M E, Yamaoka Manami, Das Anshuman, Kapustina Maryna, Shah Pranav, Muramatsu Masamichi, Wang Xiangxi, Fry Elizabeth E, Stuart David I, Lemon Stanley M

Identification of a peptide inhibitor disrupting the PCSK9-LDLR interaction via pharmacophore-based virtual screening, molecular dynamics simulations and in vitro/vivo evaluation.

通过基于药效团的虚拟筛选、分子动力学模拟和体外/体内评价,鉴定出一种能够破坏 PCSK9-LDLR 相互作用的肽抑制剂。

Wu Wanling, Yang Shudan, Liu Jie, Wang Yuting, Pan Defeng, Zhou Yafeng

Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice.

肝细胞 FOXA3 的缺失可改善高脂血症 Ldlr 缺陷小鼠的 MASH 和动脉粥样硬化。

Wang Hui, Hu Shuwei, Wang Jiayou, Gopoju Raja, Lin Li, Gunawardana Lakshitha, Wang Xinwen, Yin Liya, Zhang Yanqiao

Functional analysis from ex-vivo characterization of LDLR exon 13-15 duplication associated to familial hypercholesterolemia

通过离体表征对与家族性高胆固醇血症相关的LDLR外显子13-15重复进行功能分析

Martínez, Catalina; Alarcón, Carolina; Radojkovic, Claudia; Cid, Andrea; Vilches, Noemí; Guzman-Gutiérrez, Enrique; Saez, Katia; Alonso, Rodrigo; Sánchez, Andrea

Novel start codon variant in the 5'UTR of LDLR associated with familial hypercholesterolaemia

LDLR 5'UTR 中与家族性高胆固醇血症相关的新型起始密码子变异

Bird, Martin; Tung, Chris Jyun-Peng; Pittman, Alan M; Behr, Elijah R; Nohturfft, Axel; Futema, Marta

LDLR(+) Monocytic Myeloid-derived Suppressor Cells Attenuate Allograft Rejection in Liver Transplantation

LDLR(+)单核细胞来源的髓系抑制细胞可减轻肝移植中的同种异体移植排斥反应

Zhou, Xin; Li, Xinqiang; Jiang, Peng; Li, Shipeng; Jia, Zhuoyu; Wang, Xueteng; Cai, Hailun; Liu, Huan; Ding, Ruidong; Cai, Jinzhen

SiRNA-based inactivation of Angptl3 alleviates high-fat diet-induced MAFLD and atherosclerosis in LDLR-deficient hamsters

基于siRNA的Angptl3失活可减轻LDLR缺陷仓鼠高脂饮食诱导的MAFLD和动脉粥样硬化

Zhang, Xiaohong; Han, Yufei; Zheng, Liwen; He, Xiaokui; Pu, Yungang; Wei, Lili; Wang, Yuhui; Xian, Xunde

First LDLRAP1 and Recurrent LDLR Mutations in Tunisian Families With Familial Hypercholesterolemia

突尼斯家族性高胆固醇血症患者中首次发现LDLRAP1和复发性LDLR突变

Ncir, Wirath Ben; Ben-Mahmoud, Afif; Frikha, Hamdi; Abdelhedi, Fatma; Kacem, Faten Hadj; Majdoub, Nabila; Mnif, Mouna; Kim, Hyung-Goo; Keskes, Leila Ammar; Hottenga, Jouke-Jan

Identification of a Novel VLDLR Variant in the First Report of CAMRQ1 From Africa: Expanding the Spectrum of Cerebellar Ataxia Syndromes

在首例来自非洲的CAMRQ1病例报告中鉴定出一种新的VLDLR变异:扩展了小脑共济失调综合征的谱系

Jawabri, Aseel A; Salazar-Villacorta, Ainara; Senghor, Henriette; Ndiaye, Rokhaya; Al-Mehrzi, Alia; Diop, Amadou Gallo; Ndiaye, Moustapha; Ali, Bassam R; Rodriguez Cruz, Pedro M