日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer.

转移性结直肠癌中 EMP1+ 到 LGR5+ 细胞状态的转化可绕过 KRASG12D 药物抑制。

Centonze Alessia, Roura Adrià-Jaume, Novillo-Font Meritxell, Giordano Cristina, Hernando-Momblona Xavier, Llanses Montserrat, Prats Paula, Sevillano Marta, Cabot Débora, Novell Mireia, Pabst Gabriel, Andersch Florian, Cañellas-Socias AdriÃ, Zhang Chong, Giakoumakis Nikolaos-Nikiforos, Sparks Hugh, Dunsby Chris, Colombelli Julien, Fernández-Barral Asunción, Sancho Elena, Stephan-Otto Attolini Camille, Muñoz Alberto, Barbachano Antonio, Palmer Héctor G, Martínez-Quintanilla Jordi, Zuber Johannes, Blaj Cristina, Quintana Elsa, Cortina Carme, Marti-Renom Marc A, Batlle Eduard

LGR5: from stem cell marker to therapeutic target

LGR5:从干细胞标志物到治疗靶点

High, Peyton C; Cappellino, Maya G; Blackburn, Tiffani A; Carmon, Kendra S

Injectable hydrogel microspheres delivering cartilage-targeted LGR5-engineered exosomes for osteoarthritis therapy.

用于治疗骨关节炎的可注射水凝胶微球,该微球可递送靶向软骨的 LGR5 工程化外泌体。

Shang Kejia, Fu Chunxu, Li Ruxin, Yu Wenting, Han Yuanyuan, Cheng Fangyan, Chen Wei, Qin Jin, Li Ye, Zhang Yingze, Wang Juan, Feng Chen

Lgr5⁺ cells regulate small intestinal morphogenesis before villification.

Lgr5â º 细胞在绒毛形成之前调节小肠形态发生。

Zhao Lianzheng, Xie Yuchen, Song Wanlu, Shen Yonghui, Liu Huidong, Luo Shiwen, Chen Ye-Guang

Low LAMA2 expression may affect drug resistance and prognosis in ovarian cancer via positive LGR5 coexpression

LAMA2低表达可能通过与LGR5正向共表达影响卵巢癌的耐药性和预后。

Du, Zhe; Su, Yuting; Xia, Lianping; Lei, Shunmei; Ke, Yao; Chen, Xiaoying; Liu, Xia; Yin, Fuqiang

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages

舌后部的三能性Lgr5干细胞可分化生成舌腺、味腺和唾液腺谱系。

Laurens H G Verweij #,Seok-Young Kim #,Dimitrios Laskaris,Lin Lin,Gijs J F van Son,Femke C A S Ringnalda,Harry Begthel,Ravian L van Ineveld,Chris Winkel,Jay P Slack,Anne C Rios,Karin Sanders,Jacco van Rheenen,Marc van de Wetering,Hans Clevers

Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation

癌相关成纤维细胞通过CLEC11A/LGR5介导的WNT信号通路激活促进结直肠癌淋巴转移。

Zhang, Chuhan; Pan, Teng; Zhang, Yuyuan; Wu, Yushuai; Zuo, Anning; Liu, Shutong; Ba, Yuhao; Liu, Benyu; Yang, Shuaixi; Chen, Yukang; Xu, Hui; Luo, Peng; Cheng, Quan; Weng, Siyuan; Liu, Long; Zhou, Xing; Ning, Jingyuan; Han, Xinwei; Deng, Jinhai; Liu, Zaoqu

Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models

西妥昔单抗可增加 LGR5 表达,并增强 LGR5 靶向抗体药物偶联物在患者来源的结直肠癌模型中的疗效。

High, Peyton C; Liang, Zhengdong; Guernsey-Biddle, Cara; Subramanian, Shraddha; Shyu, Yueh-Ming; Aldana, Adela M; Toh, Yukimatsu; Carmon, Kendra S

LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance

LGR5:癌症转移和化疗耐药性的新兴治疗靶点

Wang, Wanqi; Lokman, Noor A; Barry, Simon C; Oehler, Martin K; Ricciardelli, Carmela

LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer.

LGR5 与 HSP90AB1 相互作用,通过激活前列腺癌中的 WNT/β-catenin/AR 轴介导恩扎卢胺耐药性。

Gao Ze, Xiong Zhi, Tao Yiran, Wang Qiong, Guo Kaixuan, Xu Kewei, Huang Hai