日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

COL1A1-induced LOXL2 promotes ovarian cancer metastasis via a feedback loop upon inhibiting EGFR lysosomal degradation

COL1A1诱导的LOXL2通过抑制EGFR溶酶体降解的反馈环路促进卵巢癌转移。

Shen, Zhangjin; Gu, Lingkai; Zheng, Mengxia; Liu, Yuwan; Shang, Shanliang; Zhu, Yunshan; Lu, Weiguo

LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosis.

LOXL2 缺失会引发颞下颌关节骨关节炎,而过表达则会保护其免受 NF-κB 诱导的软骨细胞凋亡。

LOXL2⁺ cancer-associated fibroblasts shape WNT signaling to drive chemoresistance and poor outcomes in colorectal cancer: Insights from multi-omics and epidemiological analyses

LOXL2⁺ 癌相关成纤维细胞通过调控 WNT 信号通路驱动结直肠癌的化疗耐药性和不良预后:来自多组学和流行病学分析的启示

Xu, Chengyuan; Li, Tengfei; Zhang, Lin; Zhang, Qin; Cai, Shanshan; Fu, Qiangqiang; Zhang, Siqi

Spatial transcriptomics and single-cell analyses reveal the role of the cisplatin-resistant gene panel in NSCLC progression and the tumor microenvironment, identifying LOXL2 as a potential therapeutic target

空间转录组学和单细胞分析揭示了顺铂耐药基因谱在非小细胞肺癌进展和肿瘤微环境中的作用,并将LOXL2鉴定为潜在的治疗靶点。

Liu, Junzhi; Li, Huimin; Jiao, Yuheng; Hou, Meng

A novel cell-permeable LOXL2 inhibitor PAT-1251 potently suppresses biliary liver fibrosis via collagen crosslinking-dependent and -independent mechanisms

一种新型的细胞渗透性LOXL2抑制剂PAT-1251可通过胶原交联依赖性和非依赖性机制有效抑制胆汁性肝纤维化。

An, Ping; Wei, Guangyan; Huang, Pinzhu; Matta, Heansika; Li, Wenda; Lin, Yi; Wang, Jing; Gretchen, Bain; Popov, Yury V

FGF-23 facilitates osteosarcoma metastasis by modulating the miR-4463/LOXL2 axis expression via the ERK, p38, and JNK signaling pathway

FGF-23通过ERK、p38和JNK信号通路调节miR-4463/LOXL2轴的表达,从而促进骨肉瘤转移。

Hou, Chun-Han; Lin, Chih-Yang

LOX and LOXL2 Expression in Canine Mammary Carcinomas.

犬乳腺癌中 LOX 和 LOXL2 的表达。

Small-molecule LOXL2 inhibition as a novel antifibrotic strategy for the treatment of myocardial fibrosis

小分子LOXL2抑制剂作为一种治疗心肌纤维化的新型抗纤维化策略

Nadeem, Huzaifa; Khan, Waleed Ahmad; Mahato, Raghabendra Kumar

GPR4 promotes immune exclusion in colon cancer through LOXL2-mediated extracellular matrix remodeling.

GPR4 通过 LOXL2 介导的细胞外基质重塑促进结肠癌的免疫排斥。

ROS-degradable hydrogel delivering LOXL2-LNPs rescues disc degeneration by synchronously suppressing cellular senescence and oxidative damage

递送LOXL2-LNPs的ROS可降解水凝胶通过同步抑制细胞衰老和氧化损伤来挽救椎间盘退变。

Zhang, Jian; Li, Yang; Ding, Rui; Pan, Chongzhi; Xie, Jiajun; Huang, Guanfeng; Chen, Xiaolong; Zhao, Xiaokun; Miao, Xinxin; Cheng, Xigao