日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation

强效且选择性的LSD1抑制剂DC551040揭示了一种有前景的AML联合疗法,并有助于深入了解表观遗传失调。

Wang, Jiang; Wang, Hanlin; Du, Runhua; Li, Chunpu; Su, Mingbo; Wang, Shuni; Kan, Weijuan; Liu, Guobin; Zhang, Yu; Hu, Xiaobei; Gao, Feng; Xu, Gaoya; Li, Cong; Zhu, Wei; Ye, Yunfei; Sheng, Li; Shi, Yuqiang; Shao, Yingying; Song, Jiangzhou; Wang, Yuxian; Wang, Bo; Zhou, Yubo; Huang, He; Li, Jia; Liu, Hong

Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression.

抑制 LSD1 可解锁类视黄醇 AP-1 程序,从而激活上皮免疫和皮肤肿瘤抑制。

Kuprasertkul Nina, Moore Alyssa F, D'souza Carina A, Chini Julia, Ko Eun-Kyung, Huang Sijia, Zhang Shuo, Anderson Ashley S, Egolf Shaun, Pinheiro Laura V, Jaccard Alison, Magahis Claudia T, Bao Lydia, Aubert Yann, Olingou Cyria, Prouty Stephen M, Brennan-Crispi Donna, Hill David A, Seykora John T, Wellen Kathryn E, Capell Brian C

Epigenetically silenced KAT2B suppresses de novo lipogenesis through destroying HDAC5/LSD1 complex assembly in renal cell carcinoma

表观遗传沉默的KAT2B通过破坏肾细胞癌中HDAC5/LSD1复合物的组装来抑制从头脂肪生成

Wang, Qi; Miao, Daojia; Liu, Ruijie; Li, Mingfeng; Dong, Zirui; Liu, Yuenan; Yang, Chao; Yang, Hongmei; Wang, Keshan; Xiong, Zhiyong; Zhang, Xiaoping

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

PRMT5 和 LSD1 抑制剂在急性髓系白血病中存在协同作用。

Param Nesteene Joy, Arceci Elisa, Fiorentino Francesco, Pignata Luca, Torre Denis, Gutiérrez-Trejo Nayeli, Fong Jia Yi, Goy Pierre-Alexis, Han Brenda Y, Lambona Chiara, Di Bello Elisabetta, Castiello Carola, Barone Marco, Schwarz Megan, Arrowsmith Cheryl, Ito Koichi, Scherle Peggy, Wee Dave Keng Boon, Ndoye Steven, Tabaglio Tommaso, Jeyasekharan Anand D, Lakshmanan Manikandan, Cirilli Roberto, Habisch Hansjörg, Madl Tobias, Mattevi Andrea, Valente Sergio, Mai Antonello, Guccione Ernesto

LSD1 maintains oocyte quality by epigenetically repressing CAMK2β to control granulosa cell-oocyte communication.

LSD1 通过表观遗传抑制 CAMK2β 来控制颗粒细胞与卵母细胞之间的通讯,从而维持卵母细胞的质量。

Zhang Jixian, Yu Yuanyuan, Zhu Zijian, Zhang Heng, Hu Zhu, Sheng Zhiyi, He Meina, Zhang Tuo

Follicle stimulating hormone stimulates farnesyl-diphosphate farnesyltransferase 1 expression through LSD1Ser54p in chicken ovarian granulosa cells

促卵泡激素通过LSD1Ser54p位点刺激鸡卵巢颗粒细胞中法尼基二磷酸法尼基转移酶1的表达。

Zhang, Yanhong; Zhang, Min; Liu, Qingxin; Jiang, Yunliang

The novel tertiary amine LSD1 inhibitor 596 inhibits endometrial cancer through the mTOR signal transduction pathway.

新型叔胺 LSD1 抑制剂 596 通过 mTOR 信号转导通路抑制子宫内膜癌。

Wang Chunli, Shen Dandan, Lin Nanshan, Wang Panjie, Bi Yaping, Hu Huina, Shang Yujia, Ren Chenchen, Yang Li, Ma Qisheng

LSD1 promotes prostate cancer cell proliferation by upregulating PRAC1 expression

LSD1通过上调PRAC1表达促进前列腺癌细胞增殖

Liao, Yang; Liu, Chuan

LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma

LSD1 在尤文氏肉瘤中发挥去甲基酶非依赖性和情境特异性作用

Dreher, Rachel D; Taslim, Cenny; Miller, Ira; Sherman, John W; Bayanjargal, Ariunaa; Theisen, Emily R

Therapeutic advances in acute myeloid leukemia: from LSD1 blockade to PROTAC-based strategies

急性髓系白血病治疗进展:从LSD1阻断到基于PROTAC的策略

Khan, Sarum A; Qamar, Muhammad A; Feroze, Muhammad T