LYN相关文献与解析，生知库 | 链接生命科学的每一步

Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcÎµRI/Lyn + Syk/MAPK Pathway.

Vasicine 通过调节 FcÎµRI/Lyn + Syk/MAPK 通路抑制肥大细胞脱颗粒和 Th2 炎症，从而减轻过敏性哮喘。

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph19010190

Immunology/Inflammation

炎症

发表日期：2026

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Mesothelin promotes acute myeloid leukemia progression through LYN-dependent signaling

间皮素通过LYN依赖性信号通路促进急性髓系白血病进展

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2026.111390

Faust, Joshua R; Hamill, Darcy; Kolb, E Anders; Stevens, Alexandra M; Gopalakrishnapillai, Anilkumar; Barwe, Sonali P

Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse.

在没有吞噬突触的情况下，Lyn 对 SHIP1 的基础磷酸化抑制促炎信号传导。

期刊:Journal of Immunology

影响因子:3.4

doi:10.1093/jimmun/vkaf372

Senevirathne S Erandika, Kanagy William K, Hemmila Charlotte R, Greene Joseph T, Rajczewski Andrew T, Cattley Richard T, Swanson Whitney L, Toledo Ramos Silvia, Nunez Myra G, Jin Siyu, Hawse William F, Freedman Tanya S

FLYNC: a machine-learning-driven framework for discovering long noncoding RNAs in Drosophila melanogaster

FLYNC：一种基于机器学习的果蝇长链非编码RNA发现框架

期刊:NAR Genomics and Bioinformatics

影响因子:2.8

doi:10.1093/nargab/lqaf216

Dos Santos, Ricardo F; Baptista, Tiago; Marques, Graça S; Homem, Catarina C F

Macrophage Lyn Kinase Is a Sex-Specific Regulator of Post-Subarachnoid Hemorrhage Neuroinflammation

巨噬细胞 Lyn 激酶是蛛网膜下腔出血后神经炎症的性别特异性调节因子

期刊:Journal of the American Heart Association

影响因子:5

doi:10.1161/JAHA.124.039409

Rezwanul Islam ，Hadi Hasan Choudhary ，Feng Zhang ，Hritik Mehta ，Jun Yoshida ，Ajith Thomas ，Khalid Hanafy

Regulation of hepatic organic anion transporting polypeptide 1B-type transport function by the protein kinase LYN

蛋白激酶LYN对肝脏有机阴离子转运多肽1B型转运功能的调节

期刊:Drug Metabolism and Disposition

影响因子:4

doi:10.1016/j.dmd.2025.100138

Xu, Vivian; Nepal, Mahesh R; Ahmed, Eman; Kaczynski, Benjamin D; Xu, Yue; Gallo, James M; Huang, Kevin M; Sparreboom, Alex; Hu, Shuiying; Sprowl, Jason A

The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial

MyChoices 和 LYNX 移动应用程序对美国年轻性少数男性 HIV 检测和暴露前预防药物使用情况的影响：一项全国性随机对照试验的结果

期刊:Jmir Public Health and Surveillance

影响因子:3.9

doi:10.2196/63428

Biello, Katie B; Mayer, Kenneth H; Scott, Hyman; Valente, Pablo K; Hill-Rorie, Jonathan; Buchbinder, Susan; Ackah-Toffey, Lucinda; Sullivan, Patrick S; Hightow-Weidman, Lisa; Liu, Albert Y

Refining maintenance strategies for metastatic nonsquamous non-small cell lung cancer: insights from the KEYLYNK-006 study

优化转移性非鳞状非小细胞肺癌的维持治疗策略：来自 KEYLYNK-006 研究的启示

期刊:Translational Lung Cancer Research

影响因子:3.5

doi:10.21037/tlcr-2025-639

Kemper, Marcel; Griesinger, Frank; Bleckmann, Annalen

LYN mutations in breast cancer: hypothesis-generating evidence for an association with central nervous system metastasis and domain-level insights

乳腺癌中的LYN基因突变：与中枢神经系统转移相关的假设生成证据及结构域水平见解

期刊:BMC Cancer

影响因子:3.4

doi:10.1186/s12885-025-15398-w

Çağdaş, Elif Kardelen; Çağdaş, Berkay

MST1 bridges LYN and SHP-1 to suppress FcÎµRI-mediated mast cell activation and allergic responses.

MST1 连接 LYN 和 SHP-1，抑制 FcαRI 介导的肥大细胞活化和过敏反应。

Vasicine Attenuates Allergic Asthma by Suppressing Mast Cell Degranulation and Th2 Inflammation via Modulation of the FcÎµRI/Lyn + Syk/MAPK Pathway.

Vasicine 通过调节 FcÎµRI/Lyn + Syk/MAPK 通路抑制肥大细胞脱颗粒和 Th2 炎症，从而减轻过敏性哮喘。

Mesothelin promotes acute myeloid leukemia progression through LYN-dependent signaling

间皮素通过LYN依赖性信号通路促进急性髓系白血病进展

Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse.

在没有吞噬突触的情况下，Lyn 对 SHIP1 的基础磷酸化抑制促炎信号传导。

FLYNC: a machine-learning-driven framework for discovering long noncoding RNAs in Drosophila melanogaster

FLYNC：一种基于机器学习的果蝇长链非编码RNA发现框架

Macrophage Lyn Kinase Is a Sex-Specific Regulator of Post-Subarachnoid Hemorrhage Neuroinflammation

巨噬细胞 Lyn 激酶是蛛网膜下腔出血后神经炎症的性别特异性调节因子

Regulation of hepatic organic anion transporting polypeptide 1B-type transport function by the protein kinase LYN

蛋白激酶LYN对肝脏有机阴离子转运多肽1B型转运功能的调节

The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial

MyChoices 和 LYNX 移动应用程序对美国年轻性少数男性 HIV 检测和暴露前预防药物使用情况的影响：一项全国性随机对照试验的结果

Refining maintenance strategies for metastatic nonsquamous non-small cell lung cancer: insights from the KEYLYNK-006 study

优化转移性非鳞状非小细胞肺癌的维持治疗策略：来自 KEYLYNK-006 研究的启示

LYN mutations in breast cancer: hypothesis-generating evidence for an association with central nervous system metastasis and domain-level insights

乳腺癌中的LYN基因突变：与中枢神经系统转移相关的假设生成证据及结构域水平见解