LZTS2相关文献与解析，生知库 | 链接生命科学的每一步

Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT

破坏细胞核内CCDC137介导的LZTS2和β-TrCP相互作用可通过β-catenin和AKT抑制肝细胞癌的发生发展。

Xu, Lei; Liu, Qiumeng; Liu, Hailing; Fan, Feimu; Li, Pengcheng; Yue, Shiwei; Mo, Jie; Liu, Zhicheng; Dong, Renshun; Zhang, Xuewu; Dong, Hanhua; Liang, Huifang; Chen, Xiaoping; Zhang, Bixiang; Chen, Lin; Chen, Jin

肿瘤

SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway

SPOP和HAUSP双向调控LZTS2的泛素化，从而调节Wnt信号通路。

期刊:Cell Death & Disease

影响因子:9.6

doi:10.1038/s41419-025-08351-z

Deng, Yanran; Xie, Chunfan; Liu, Ran; Ma, Kaize; Tang, Jian; Zhou, Zizhang

Retraction Note: β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

撤稿声明：β-Trcp 和 CK1δ 介导的 LZTS2 降解激活 PI3K/AKT 信号通路，从而驱动肝细胞癌的肿瘤发生和转移。

期刊:Oncogene

影响因子:7.3

doi:10.1038/s41388-025-03344-w

Lu, Yanwei; Li, Xudong; Liu, Hongli; Xue, Jun; Zeng, Zhen; Dong, Xiaorong; Zhang, Tao; Wu, Gang; Yang, Kunyu; Xu, Shuangbing

LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses

LZTS2甲基化作为肝内胆管癌和胃腺癌的潜在诊断和预后标志物：来自生物信息学和体外分析的证据

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-03153-x

Wang, Xiao; Lu, Yanwei; Liu, Ruiqi; Huang, Luanluan; Xu, Keke; Xiong, Hao; Nan, Ding; Shou, Yiyi; Sheng, Hailong; Zhang, Haibo; Wang, Xian; Chen, Xiaoyan

Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis

长链非编码 RNA linc00921 通过靶向 miR-9-5p/LZTS2 轴抑制三阴性乳腺癌的肿瘤发生和上皮-间质转化

期刊:Human Cell

影响因子:3.4

doi:10.1007/s13577-022-00685-6

Jie Zhang, Lina Zhang, Jianlong Wang, Jing Zhao, Xuelian Zhao, Chunli Zhang, Peng Han, Cuizhi Geng

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

β-Trcp 和 CK1δ 介导的 LZTS2 降解激活 PI3K/AKT 信号传导从而驱动肝细胞癌的肿瘤发生和转移

期刊:Oncogene

影响因子:6.9

doi:10.1038/s41388-020-01596-2

Yanwei Lu #, Xudong Li #, Hongli Liu #, Jun Xue, Zhen Zeng, Xiaorong Dong, Tao Zhang, Gang Wu, Kunyu Yang, Shuangbing Xu

LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis

LZTS2和PTEN协同调控前列腺肿瘤发生中的β-catenin

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0174357

Yu, Eun-Jeong; Hooker, Erika; Johnson, Daniel T; Kwak, Mi Kyung; Zou, Kang; Luong, Richard; He, Yongfeng; Sun, Zijie

LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin

LZTS2 是一种新型的 β-catenin 相互作用蛋白，它调控 β-catenin 的核输出。

期刊:Molecular and Cellular Biology

影响因子:2.7

doi:10.1128/MCB.01031-06

Thyssen, Gregory; Li, Tzu-Huey; Lehmann, Lynn; Zhuo, Ming; Sharma, Manju; Sun, Zijie

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation.

LZTS2 负调控中心体 CEP135 水平和微管成核。

Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT

破坏细胞核内CCDC137介导的LZTS2和β-TrCP相互作用可通过β-catenin和AKT抑制肝细胞癌的发生发展。

SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway

SPOP和HAUSP双向调控LZTS2的泛素化，从而调节Wnt信号通路。

Retraction Note: β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

撤稿声明：β-Trcp 和 CK1δ 介导的 LZTS2 降解激活 PI3K/AKT 信号通路，从而驱动肝细胞癌的肿瘤发生和转移。

LZTS2 methylation as a potential diagnostic and prognostic marker in LIHC and STAD: Evidence from bioinformatics and in vitro analyses

LZTS2甲基化作为肝内胆管癌和胃腺癌的潜在诊断和预后标志物：来自生物信息学和体外分析的证据

Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis

长链非编码 RNA linc00921 通过靶向 miR-9-5p/LZTS2 轴抑制三阴性乳腺癌的肿瘤发生和上皮-间质转化

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

β-Trcp 和 CK1δ 介导的 LZTS2 降解激活 PI3K/AKT 信号传导从而驱动肝细胞癌的肿瘤发生和转移

LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis

LZTS2和PTEN协同调控前列腺肿瘤发生中的β-catenin

LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin

LZTS2 是一种新型的 β-catenin 相互作用蛋白，它调控 β-catenin 的核输出。