日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4-VCAM1 Signaling

内皮细胞中 Rap2a 的失活通过 MAP4K4-VCAM1 信号通路调节免疫微环境，从而预防肺纤维化

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202519892
Zheng, Xiaolan; Yue, Peng; Zhou, Kaiyu; Gong, Guidong; Zhang, Yue; Lin, Sha; Liu, Xu; Zheng, Yanjiang; Jing, Siyuan; Guo, Junling; Qi, Yan; Ding, Bi-Sen; Hua, Yimin; Li, Yifei
信号转导
MAP4
内皮细胞
细胞生物学
VCAM1
免疫/内分泌
发表日期：2026
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MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation.

MAP4K2 通过促进 Treg 分化来抑制胰腺癌模型中的抗肿瘤免疫。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI196379
Chuang Huai-Chia, Wang Chia-Wen, Hsueh Chia-Hsin, Xiao Yu-Zhi, Tsai Ching-Yi, Hsu Pu-Ming, Tan Evelyn L, Chiu Hsien-Yi, Tan Tse-Hua
肿瘤
T细胞
肿瘤免疫
MAP4
Treg
胰腺癌
免疫/内分泌
发表日期：2026
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Erratum: MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation: Erratum

更正：MAP4K3/GLK通过直接磷酸化IKKβ并诱导IKKβ介导的FoxO1核输出和Foxp3下调来抑制Treg细胞分化：更正

期刊:Theranostics
影响因子:13.3
doi:10.7150/thno.125465
Chi, Jyun-Ni; Yang, Jhih-Yu; Hsueh, Chia-Hsin; Tsai, Ching-Yi; Chuang, Huai-Chia; Tan, Tse-Hua
T细胞
信号转导
MAP4
Treg
磷酸化
细胞生物学
发表日期：2026
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Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling

circ-CDK8表达异常通过调节let-7b-5p/MAP4K3信号通路影响牙周炎的发展

期刊:Regenerative Therapy
影响因子:3.5
doi:10.1016/j.reth.2026.101075
Li, Yabo; Yang, Cailing; Jin, Mengdie; Liu, Ting; Yuan, Changqing; Zheng, Jingjing
信号转导
MAP4
CDK8
发表日期：2026
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Correction to "Peptide Transporter 1-Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis"

更正“肽转运蛋白1介导的二肽转运通过激活MAP4K4/G3BP2信号轴促进肝细胞癌转移”

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202504116
肿瘤
肿瘤免疫
信号转导
MAP4
G3BP2
3BP2
细胞生物学
发表日期：2025
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MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities

MAP4K信号通路在癌症中的作用、机制和治疗机遇

期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-025-01544-8
Bunardi, Chyntia Sherlyn; Yeom, Minseo; Kosasih, Prisca; Han, Han; Wang, Wenqi; Seo, Gayoung
信号转导
MAP4
肿瘤
肿瘤免疫
发表日期：2025
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MAP4K1 and MAP4K2 regulate ABA-induced and Ca2+-mediated stomatal closure in Arabidopsis

MAP4K1和MAP4K2调控拟南芥中ABA诱导和Ca2+介导的气孔关闭

期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.adt4916.
Kota Yamashita,Sotaro Katagiri,Hinano Takase,Yangdan Li,Anzu Oishi,Airi Otoguro,Yoshiaki Kamiyama,Shota Yamauchi,Yuh-Shuh Wang,Atsushi Takemiya,Izumi C Mori,Hannes Kollist,Taishi Umezawa
信号转导
MAP4
发表日期：2025
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MAP4 phosphorylation induced by ARID1A loss sensitizes colorectal cancer cells to EMP

ARID1A缺失诱导的MAP4磷酸化使结直肠癌细胞对EMP敏感。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-08286-5
Pan, Lei; Wu, Danzhu; He, Yilin; Wang, Kejin; Zeng, Yingyi; Xiang, Cheng; Huang, Lifang; Qin, Wenjie; Zhang, Xu; Wang, Zihuan; Yu, Yingnan; Wang, Zhen; Xiang, Li; Wu, Changjie; Li, Aimin
肿瘤
肠癌
肿瘤免疫
ID1
信号转导
MAP4
磷酸化
细胞生物学
发表日期：2025
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Proteasome stress activates YAP/TAZ through the RAP2-MAP4Ks-LATS1/2 pathway and its therapeutic implications in solid tumors

蛋白酶体应激通过 RAP2-MAP4Ks-LATS1/2 通路激活 YAP/TAZ，及其在实体瘤治疗中的意义

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2517376122
Wang, Xin; Gu, Yuan; Zhong, Zhenxing; Yu, Pengcheng; Liu, Wenshuai; Zhu, Rui; Wang, Yu; Zhou, Zhaocai; Sun, Yihong; Wang, Xuefei; Yu, Fa-Xing
TAZ
信号转导
MAP4
LATS1
LAT
ATS1
YAP
发表日期：2025
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N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4

N6-甲基腺苷读取蛋白IGF2BP2修饰的HMMR通过与MAP4K4相互作用促进非小细胞肺癌转移

期刊:International Journal of Biological Sciences
影响因子:8.2
doi:10.7150/ijbs.104097
Jiansheng Zhang,Mengzhu Zhang,Aimin Qiu,Chang Li,Qiongju Chen,Jianjun Li,Yuanyuan Zeng,Jianjie Zhu,Jian-An Huang,Xiuqin Zhang,Zeyi Liu
肺癌
细胞生物学
肿瘤
表观遗传
MAP4
发表日期：2025
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