MAVS相关文献与解析，生知库 | 链接生命科学的每一步

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8(+)T cell-mediated anti-tumor immunity

CD38通过线粒体自噬降解MAVS，从而抑制鼻咽癌细胞中I型干扰素的分泌，并削弱CD8(+)T细胞介导的抗肿瘤免疫。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-026-69339-7

Liang, Lin; Li, Wentao; Liu, Siyi; He, Qian; Zeng, Feng; Cao, Jiaying; Lei, Yan; Li, Yanling; Zhou, Yanhong

N6-methyladenosine modification of FZR1 mRNA positively regulates antiviral innate immunity by targeting the MAVS-TRAF3/6 axis

FZR1 mRNA的N6-甲基腺苷修饰通过靶向MAVS-TRAF3/6轴正向调控抗病毒先天免疫。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2536412123

Dou, Kaiwen; Hu, Yiyi; Li, Mingyang; Xu, Jiale; Zhang, Weihao; Wang, Hui; Cheng, Qi; Jiang, Zihao; Chen, Liangjun; Liu, Shi; Chen, Ke; Liu, Yuanyuan; Xiong, Hairong; Luo, Fan; Hou, Wei; Chen, Shuliang

C-terminal tail of MAVS dictates organelle targeting and innate immune response

MAVS的C端尾部决定其对细胞器的靶向定位和先天免疫反应。

期刊:Cell Communication and Signaling

影响因子:8.9

doi:10.1186/s12964-026-02753-y

Lee, Terence Tak-Wang; Cham, Kiki; Jin, Dong-Yan

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity.

DNMT 抑制通过表观遗传学恢复 cGAS-STING 通路并激活 RIG-I/MDA5-MAVS 来增强抗肿瘤免疫力。

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01639-y

Tu Yao, Zhu Qing-Yun, Huang Wen-Jun, Feng Sha, Tan Yu-Ling, Li Lu-Lu, Xie Xin-Tong, Li Qin-Yuan, Huang Shou-Hui, Mao Cheng-Zhou, Chu Bi-Zhu, Jiang Yu-Yang

Human cGAS Drives LINE-1 Transcriptional Activation to Trigger MAVS-Dependent Cellular Senescence.

人类 cGAS 驱动 LINE-1 转录激活，从而触发 MAVS 依赖性细胞衰老。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70484

Chen Zhixi, Chen Lingjiang, Chen Xinyu, Wang Hao, Tang Huanyin, Zhen Zhengyi, Jiang Ying, Mao Zhiyong, Chen Yu

Nervous necrosis virus capsid protein functions as a SUMO E3 ligase to activate MAVS-dependent NF-κB signaling

神经坏死病毒衣壳蛋白作为SUMO E3连接酶，激活MAVS依赖的NF-κB信号通路。

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-026-06155-8

Zhang, Wanwan; Chen, Xiaoqi; Sun, Bingbing; Yao, Lan; Xiong, Xingchen; Yi, Meisheng; Jia, Kuntong

CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response

CRM1依赖的TRIM28核输出促进MAVS K48连接的泛素化并抑制RIG-I介导的抗病毒反应

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1744833

Xin, Ruihua; Zou, Wenshu; Qiu, Zhengying; Huang, Lina; Jing, Xiaohan; Huang, Qilin; Zhu, Zixiang; Li, Jianxi; Garigliany, Mutien-Marie

Metabolic-Epigenetic Crosstalk in Takayasu Arteritis: The ANK2-MAVS-IL-8 Axis as a Novel Therapeutic Paradigm

大动脉炎中的代谢-表观遗传串扰：ANK2-MAVS-IL-8轴作为一种新型治疗范式

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27073249

Xie, Tianjian; Zhang, Leyu; Li, Shurong; Xu, Benmo; Zhang, Xinyu; Wang, Yajun; Shang, Zixiang; Xi, Hongxuan; Shi, Han; Ni, Xin; Li, Ping; Li, Hengxi

The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response.

猪星状病毒 nsP1a/3 的 3C 样丝氨酸蛋白酶活性介导线粒体凋亡和 MAVS 裂解，从而促进病毒复制并拮抗 I 型干扰素反应。

期刊:PLoS Pathogens

影响因子:4.9

doi:10.1371/journal.ppat.1013987

Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response.

朊病毒样 MAVS 原纤维连接线粒体，促进快速抗病毒反应。

CD38 degrades MAVS through mitophagy to inhibit type I interferon secretion in nasopharyngeal carcinoma cells and impairs CD8(+)T cell-mediated anti-tumor immunity

CD38通过线粒体自噬降解MAVS，从而抑制鼻咽癌细胞中I型干扰素的分泌，并削弱CD8(+)T细胞介导的抗肿瘤免疫。

N6-methyladenosine modification of FZR1 mRNA positively regulates antiviral innate immunity by targeting the MAVS-TRAF3/6 axis

FZR1 mRNA的N6-甲基腺苷修饰通过靶向MAVS-TRAF3/6轴正向调控抗病毒先天免疫。

C-terminal tail of MAVS dictates organelle targeting and innate immune response

MAVS的C端尾部决定其对细胞器的靶向定位和先天免疫反应。

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity.

DNMT 抑制通过表观遗传学恢复 cGAS-STING 通路并激活 RIG-I/MDA5-MAVS 来增强抗肿瘤免疫力。

Human cGAS Drives LINE-1 Transcriptional Activation to Trigger MAVS-Dependent Cellular Senescence.

人类 cGAS 驱动 LINE-1 转录激活，从而触发 MAVS 依赖性细胞衰老。

Nervous necrosis virus capsid protein functions as a SUMO E3 ligase to activate MAVS-dependent NF-κB signaling

神经坏死病毒衣壳蛋白作为SUMO E3连接酶，激活MAVS依赖的NF-κB信号通路。

CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response

CRM1依赖的TRIM28核输出促进MAVS K48连接的泛素化并抑制RIG-I介导的抗病毒反应

Metabolic-Epigenetic Crosstalk in Takayasu Arteritis: The ANK2-MAVS-IL-8 Axis as a Novel Therapeutic Paradigm

大动脉炎中的代谢-表观遗传串扰：ANK2-MAVS-IL-8轴作为一种新型治疗范式

The 3C-like serine protease activity of porcine astrovirus nsP1a/3 mediates mitochondrial apoptosis and MAVS cleavage to facilitate viral replication and antagonize type I interferon response.

猪星状病毒 nsP1a/3 的 3C 样丝氨酸蛋白酶活性介导线粒体凋亡和 MAVS 裂解，从而促进病毒复制并拮抗 I 型干扰素反应。