MDM2相关文献与解析，生知库 | 链接生命科学的每一步

Wang Xu, Li Jiang, Jiang Chenggang, Zhang Chengkai, Yuan Linhao, Zhang Tieqiang, Liu Yuqi, Ma Shunchang, Kang Peng, Li Deling, Guan Xiudong, Chen Jian, Jia Wang

FUS

MDM2

发表日期：2026

文献求助收藏

Correction to 'The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation'

更正“必需转录终止因子TTF-I的细胞丰度调节核糖体生物合成，并由MDM2泛素化决定”

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkag266

NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum.

MDM2 对 NOTCH1 胞内结构域的稳定作用在非小细胞肺癌对铂类药物的反应中起着重要作用。

期刊:EMBO Molecular Medicine

影响因子:8.3

doi:10.1038/s44321-025-00354-9

Bernardo Sara, Brunet Lisa, Thomas Quentin Dominique, Bracquemond David, Bouclier CÃ©line, Colomb Marie, Mancini Maicol, Fabbrizio Eric, Santos Alba, Rasamizafy Sylvia-Fenosoa, Maacha Amina-Milissa, Giry Anais, Bousquet-Mur Emilie, Papon Laura, Goussard Marion, Fremin Christophe, Pasquier Andrea, RodrÃguez MarÃa, Travert Camille, Pujol Jean-Louis, Linares Laetitia K, Heron-Milhavet Lisa, Djiane Alexandre, Ferrer Irene, Paz-Ares Luis, Quantin Xavier, Montuenga Luis M, Tourriere HÃ©lÃ¨ne, Maraver Antonio

Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic-dysfunction-associated steatotic liver diseases.

肝脏特异性递送 MDM2 反义寡核苷酸可对抗饮食引起的代谢功能障碍相关的脂肪肝疾病。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2026.102837

Hoque Md Moinul, Kong Mengjie, Yuan Xinyi, Zhou Xiangyu, Ting-Yuan Yeh Steve, Long Kekao, Lin Huige, Yip Cheng Kenneth King

Synthesis and evaluation of RG7388-based fluorinated MDM2 inhibitors for developing (18)F-labeled probes for PET imaging

合成和评价基于RG7388的氟化MDM2抑制剂，用于开发PET成像的(18)F标记探针

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2026.118803

Siriki, Atchimnaidu; Zhou, Zhengyuan; Ragland, Graham; Chitneni, Satish K

MDM2

发表日期：2026

文献求助收藏

PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells.

PROTAC介导的MDM2靶向降解诱导骨肉瘤细胞中的肿瘤抑制信号传导。

期刊:Cells

影响因子:5.2

doi:10.3390/cells15050473

A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway

一种新型吡咯烷查尔酮衍生物通过双重靶向MDM2-p53轴和铁死亡通路，表现出协同抗宫颈癌活性。

期刊:Frontiers in Pharmacology

影响因子:4.8

doi:10.3389/fphar.2026.1715712

Xiamuxi, Hainimu; Deng, XinYi; Ablise, Mourboul; Yan, Tong; Imam, Madina; Wang, Yu; Zu, MingHui; Wumaier, Wutiekuer

The MDM2-p53 Axis in Osteosarcoma: Current Understanding of Regulatory Mechanisms and Targeted Therapeutic Strategies

骨肉瘤中的MDM2-p53轴：调控机制和靶向治疗策略的最新认识

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph19030476

Deng, Wenxia; Gao, Songyan; Yan, Lige; Su, Qiuju; Chen, Si

ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses

ENY2转录和输出复合物2亚基的缺乏会诱导核仁应激，从而通过NPM1/MDM2/p53依赖性和非依赖性反应抑制肿瘤进展。

期刊:Cellular Oncology

影响因子:4.8

doi:10.1007/s13402-025-01148-4

Zuo, Shiqi; He, Siyuan; Zhu, Zhiqin; Hou, Yanjie; Wu, Ziqing; Tang, Yao; Zou, Yujiao

The Structure, Pathogenesis, and Inhibition of the p53-MDM2 Pathway

p53-MDM2通路结构、发病机制及抑制

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers18040546

Brown, Amanda L; Lian, Xiaoying; Wang, Qian

Splicing factor FUS facilitates the progression of PIT1-lineage PitNETs by upregulating MDM2.

剪接因子 FUS 通过上调 MDM2 促进 PIT1 谱系 PitNETs 的进展。

Correction to 'The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation'

更正“必需转录终止因子TTF-I的细胞丰度调节核糖体生物合成，并由MDM2泛素化决定”

NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum.

MDM2 对 NOTCH1 胞内结构域的稳定作用在非小细胞肺癌对铂类药物的反应中起着重要作用。

Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic-dysfunction-associated steatotic liver diseases.

肝脏特异性递送 MDM2 反义寡核苷酸可对抗饮食引起的代谢功能障碍相关的脂肪肝疾病。

Synthesis and evaluation of RG7388-based fluorinated MDM2 inhibitors for developing (18)F-labeled probes for PET imaging

合成和评价基于RG7388的氟化MDM2抑制剂，用于开发PET成像的(18)F标记探针

PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma Cells.

PROTAC介导的MDM2靶向降解诱导骨肉瘤细胞中的肿瘤抑制信号传导。

A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway

一种新型吡咯烷查尔酮衍生物通过双重靶向MDM2-p53轴和铁死亡通路，表现出协同抗宫颈癌活性。

The MDM2-p53 Axis in Osteosarcoma: Current Understanding of Regulatory Mechanisms and Targeted Therapeutic Strategies

骨肉瘤中的MDM2-p53轴：调控机制和靶向治疗策略的最新认识

ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses

ENY2转录和输出复合物2亚基的缺乏会诱导核仁应激，从而通过NPM1/MDM2/p53依赖性和非依赖性反应抑制肿瘤进展。

The Structure, Pathogenesis, and Inhibition of the p53-MDM2 Pathway

p53-MDM2通路结构、发病机制及抑制