日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome

调控MECP2的选择性剪接是治疗雷特综合征的一种潜在策略。

Tirumala, Harini P; Wang, Li; Li, Yan; Bajikar, Sameer S; Anderson, Ashley G; Wang, Wei; Trostle, Alexander J; Zahabiyon, Mahla; Bajic, Aleksandar; Kim, Jean J; Chen, Hu; Liu, Zhandong; Zoghbi, Huda Y

MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids.

MeCP2失调抑制线粒体自噬,损害皮质类器官的神经发育。

Zhou Jing, Liu Yuchun, Jing Xintao, Peng Hang, Li Fang, Cao Li, Li Wen, Li Rufeng, Zhang Jinyuan, Wang Xiaofei, Lian Jiangfang, Tong Dongdong, Huang Chen

GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in Mecp2 and Disc1 transgenic mice.

GluN2B 特异性 NMDAR 正向变构调节可逆转 Mecp2 和 Disc1 转基因小鼠的认知和行为异常。

Proteomic dataset of MECP2-deficient and wild-type human brain organoids under spaceflight and ground conditions

太空飞行和地面条件下MECP2缺陷型和野生型人脑类器官的蛋白质组学数据集

Martins, Aline M A; Biagi, Diogo G; Tsu, Blake L; de Saldanha da Gama Fischer, Juliana; Coelho, Luisa Bulcao Vieira; Carvalho, Paulo Costa; Muotri, Alysson R

microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2.

microRNA-422a 通过靶向 MECP2 促进 HIV 复制和先天免疫逃逸。

Du Li, Billaud Jean-Noël, Telwatte Sushama, Kadiyala Nikhila, Dabral Prerna, Bouzidi Mohamed S, Guatelli John, Yukl Steven A, Pillai Satish K

MECP2 Rare Variants in Boys With Central Precocious Puberty

MECP2 罕见变异与中枢性性早熟男孩相关

Canton, Ana P M; Mebarak, Jacobo B; Read, Jordan E; Roberts, Stephanie A; Benson, Matthew; Shenoy, Ranjit; Meireles, Cinthia G; Magnuson, Melissa; Carroll, Rona S; Latronico, Ana Claudia; Howard, Sasha R; Kaiser, Ursula B; Abreu, Ana Paula

Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1

对雷特综合征神经元中DNA损伤的探测揭示了MECP2调控PARP1的作用

Morales, A; Korsakova, E; Mansooralavi, N; Ravikumar, A; Rivas, G; Soliman, P; Rodriguez, L; Galvan, C; McDaniel, T; Lund, A; Cooper, B; Bhaduri, A; Lowry, W E

MECP2 Insufficiency Attenuates RUNX2-Dependent Osteoblast Differentiation via miR-126-3p/DKK1-Mediated Canonical Wnt Signaling Inhibition in Rett Syndrome.

在雷特综合征中,MECP2 不足通过 miR-126-3p/DKK1 介导的经典 Wnt 信号抑制减弱 RUNX2 依赖的成骨细胞分化。

Dong Shuangshan, Wang Lu, Kato Hiroki, Hirofuji Saki, Zhou Zhiyan, Ito Yosuke, Hirofuji Yuta, Sato Hiroshi, Kato Takahiro A, Sakai Yasunari, Ohga Shouichi, Fukumoto Satoshi, Masuda Keiji

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome.

雷特综合征患者的视觉恢复反映了皮质 MeCP2 的敏感性。

Simon Alex Joseph, Picard Nathalie, d'Andrea Valeria, Chang Enchi, Leffler Joseph, Centofante Eleonora, Taylor Matthew, Bardi Francesca, Cavicchiolo Francesca, Hensch Takao K, Panzeri Stefano, Chen Chinfei, Fagiolini Michela

The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered MECP2 dysregulation?

点头综合征脑脊液蛋白质组:一种了解与环境触发的 MECP2 失调一致的神经发育障碍的视角?

Valdes Angues Raquel, Okot Caesar, Zientek Keith D, Wilmarth Phillip A, Reddy Ashok P, Odong Alfred Lucid Blair, Palmer Valerie S, Abwola Lucy Kipwola, Ogal Ensio, Okello Geoffrey, Spencer Peter S