日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma

代谢应激条件决定了结直肠癌中 MAPKAPK2 依赖的 MEK1/2 抑制效率

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2505331123
Kumari, Niti; Chen, Xu; Baldwin, Amber M; Clemons, Kristin I; El-Harakeh, Mohammad; Calisto, Lilian E; Kumar, Balawant; Zhang, Qiaoqiao; Min, Jiang; Xiao, Bin; Singh, Amar B; Wang, Bin; North, Brian J
肠癌
PKA
代谢
MEK1
MAPK/ERK
肿瘤
肿瘤免疫
发表日期：2026
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The MEK1/2-IRF4 axis fosters T follicular helper cell differentiationand antitumor humoral immune response

MEK1/2-IRF4轴促进滤泡辅助性T细胞分化和抗肿瘤体液免疫反应。

期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-026-08023-2
Ran, Shuan; Wang, Song; Li, Ran; Lai, Longyong; Yu, Jizhang; Zhang, Xi; Li, Yuan; Ye, Weicong; Zong, Junjie; Li, Xiaohan; Hao, Yanglin; Zhao, Jiulu; Luo, Zilong; Zhang, Han; Zheng, Kexiao; Huang, Pinyan; Zhan, Wang; Zou, Zifeng; Zou, Yanqiang; Cui, Jikai; Wu, Jie; Xia, Jiahong
肿瘤
T细胞
肿瘤免疫
MEK1
T细胞
细胞生物学
免疫/内分泌
发表日期：2026
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Proximity-Based Phospho-Interactome (Prob-PhI) Characterization Reveals Distinct Signaling Activities of MEK1 and MEK2

基于邻近性的磷酸化相互作用组（Prob-PhI）表征揭示了MEK1和MEK2不同的信号传导活性

期刊:Analytical Chemistry
影响因子:6.7
doi:10.1021/acs.analchem.5c05557
Wang, Ying; Xiao, Ping; Fan, Ligang; Pan, Yilin; Ma, Haiying; Wang, Rui; Xu, Cuixiang; Zhang, Liang
信号转导
MEK1
磷酸化
发表日期：2026
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MEK1/2 inhibition prevents DENV and ZIKV infection via disrupting the cytoskeletal vimentin cage required for viral replication.

MEK1/2 抑制剂通过破坏病毒复制所需的细胞骨架波形蛋白笼来阻止 DENV 和 ZIKV 感染。

期刊:Journal of Molecular Cell Biology
影响因子:5.9
doi:10.1093/jmcb/mjaf037
Huang Yuhan, Lu Jiageng, Cui Shuzhi, Zhao Shuangshuang, Sun Shengming, Jiu Yaming
细胞生物学
MEK1
发表日期：2026
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Repurposing rosmarinic acid as an anti-colorectal cancer agent through bolstering T cell anti-tumor immunity by enhancing activation of MEK1-mediated TCR signaling

通过增强MEK1介导的TCR信号通路激活，提高T细胞抗肿瘤免疫力，从而将迷迭香酸重新用于抗结直肠癌治疗

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-026-04366-3
Kang, Zhengchun; Li, Xu; Ma, Xiuzhu; Yan, Feihu; Wang, Zhen
肿瘤
肠癌
T细胞
肿瘤免疫
信号转导
MEK1
T细胞
细胞生物学
免疫/内分泌
发表日期：2026
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The adeno-associated virus Rep proteins target PP4:SMEK1 by preventing substrate recruitment.

腺相关病毒 Rep 蛋白通过阻止底物募集来靶向 PP4:SMEK1。

期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1014025
Vandewinkel Bram, Torrekens Sophie, Claes Zander, Bollen Mathieu, Henckaerts Els
MEK1
发表日期：2026
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Mechanism of MEK1 activation by phosphorylation

MEK1磷酸化激活机制

期刊:Biophysical Journal
影响因子:3.1
doi:10.1016/j.bpj.2026.02.033
Jin, Everett; Sari, Levent; Lin, Milo M
信号转导
MEK1
磷酸化
发表日期：2026
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Correction to "P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells"

对“三七皂苷R2通过MEK1/2-ERK1/2通路激活P90RSK和Nrf2以阻止6-羟基多巴胺诱导的SH-SY5Y细胞凋亡”一文的更正

期刊:Evidence-Based Complementary and Alternative Medicine
影响因子:
doi:10.1155/ecam/9810324
信号转导
凋亡
细胞生物学
MEK1
表观遗传
MAPK/ERK
发表日期：2026
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Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

丝裂原活化蛋白激酶ERK2通过其上游激酶MEK1激活的分子基础

期刊:
影响因子:
doi:10.64898/2026.01.19.700303
von Velsen, Jill; Juyoux, Pauline; Piasentin, Nicola; Fisher, Hayden; Lapouge, Karine; Vadas, Oscar; Gervasio, Francesco Luigi; Bowler, Matthew W
信号转导
MEK1
MAPK/ERK
发表日期：2026
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CircSMEK1 Suppresses HCC via the hnRNPK-IGF2-AKT Axis: A Diagnostic Biomarker and Therapeutic Target

CircSMEK1通过hnRNPK-IGF2-AKT轴抑制肝细胞癌：一种诊断生物标志物和治疗靶点

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202505267
Guo, Peilan; Jia, Xiaomeng; Wang, Shenghong; Li, Xinyu; Liu, Yajing; Lin, Lisen; Wang, Zhengkun; Liu, Fujun; Wolczynski, Slawomir; Rahman, Nafis; Gao, Jie; Du, Xuguang; Tsang, Suk-Ying; Liu, Jiali; Song, Wei; Li, Xiangdong
肿瘤
肿瘤免疫
MEK1
细胞生物学
AKT
发表日期：2025
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