日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Maternal Embryonic Leucine Zipper Kinase (MELK) in Cancer: Biological Functions, Therapeutic Potential, and Controversies

母体胚胎亮氨酸拉链激酶(MELK)在癌症中的作用:生物学功能、治疗潜力和争议

Alzeer, Alaeddin M; Al-Lahham, Saad

Design, synthesis, and biological evaluation of pyridine-quinazoline-oxadiazole hybrids as novel MELK inhibitors: in-silico analysis, anti-ovarian cancer activity, antioxidant potential, and assessment of cell cycle arrest and apoptosis

吡啶-喹唑啉-噁二唑杂合物作为新型MELK抑制剂的设计、合成和生物学评价:计算机模拟分析、抗卵巢癌活性、抗氧化潜力以及细胞周期阻滞和凋亡评估

Kumar, Akhalesh; Mishra, Rakhi

Discovery of the MELK-Nucleostemin Axis in Glioblastoma: Implications for p53 Regulation and Tumor Progression.

胶质母细胞瘤中 MELK-核仁蛋白轴的发现:对 p53 调控和肿瘤进展的影响。

Baek Songyi, Jeon Hyojin, Moon Jae-Su, Kim Young Eun, Kang Dukjin, Kim Sunghwan, Kim Kwang-Rok, Heo Kyung-Sun

MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies

MELK通过稳定肝细胞恶性肿瘤中的FABP5来阻止射频消融诱导的免疫原性细胞死亡和抗肿瘤免疫反应。

Tang, Bu-Fu; Xu, Wang-Ting; Fang, Shi-Ji; Zhu, Jin-Yu; Qiu, Rong-Fang; Shen, Lin; Yang, Yang; Weng, Qiao-You; Wang, Ya-Jie; Ding, Jia-Yi; Zhang, Xiao-Jie; Chen, Wei-Qian; Zheng, Li-Yun; Song, Jing-Jing; Chen, Biao; Zhao, Zhong-Wei; Chen, Min-Jiang; Ji, Jian-Song

Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.

Melk 通过调节 YAP/TAZ 信号通路促进肺动脉高压中肺动脉平滑肌细胞的增殖和迁移。

Yang Qiang, Chen Peisheng, He Xiaoxia, Jian Jingting, He Miaomiao, Lin Tianxiao, Zheng Shaoqiang, Liu Degang

Computational identification of Moracin G and Isolonchocarpin as potent MELK inhibitors for anticancer drug discovery

利用计算方法鉴定莫拉辛G和异龙卡品为有效的MELK抑制剂,可用于抗癌药物研发

Prasad, Prathibha; Zuberi, Azna; Ali Alzahrani, Areej; Shahnawaz Khan, Mohd

MELK study: an observational study on human milk composition and infant health determinants during the first year of life in a Dutch cohort

MELK研究:一项针对荷兰人群的观察性研究,旨在探讨母乳成分与婴儿出生第一年健康决定因素之间的关系。

Petersohn, Inga; Wang, Peiheng; van Heumen, Cindy; van Lee, Linde; Hettinga, Kasper Arthur; Belzer, Clara; van Baar, Anneloes; Feskens, Edith; Brouwer-Brolsma, Elske Maria

Upregulation of MELK promotes chemoresistance and induces macrophage M2 polarization via CSF-1/JAK2/STAT3 pathway in gastric cancer

MELK 的上调通过 CSF-1/JAK2/STAT3 通路促进胃癌的化疗耐药性并诱导巨噬细胞 M2 极化

Pengfei Su ,Tian Yu ,Yingjing Zhang ,Hongyun Huang ,Moxi Chen ,Can Cao ,Weiming Kang ,Yuqin Liu ,Jianchun Yu

EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

EZH2以MELK/FOXM1依赖的方式保护胶质瘤干细胞免受辐射诱导的细胞死亡

Kim, Sung-Hak; Joshi, Kaushal; Ezhilarasan, Ravesanker; Myers, Toshia R; Siu, Jason; Gu, Chunyu; Nakano-Okuno, Mariko; Taylor, David; Minata, Mutsuko; Sulman, Erik P; Lee, Jeongwu; Bhat, Krishna P L; Salcini, Anna Elisabetta; Nakano, Ichiro

Targeting MELK improves PD-1 blockade efficiency in cervical cancer via enhancing antitumor immunity

靶向 MELK 可通过增强抗肿瘤免疫力来提高宫颈癌中 PD-1 阻断的疗效。

Dongjiao Wang,Fei Zou,Yu Li,Jinqiu Hu,Ling Gao