日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-necroptotic MLKL function damages mitochondria and promotes hematopoietic stem cell aging

非坏死性凋亡的MLKL功能会损伤线粒体并促进造血干细胞衰老。

Yamada, Yuta; Yang, Jinjing; Saiki-Tsuchiya, Akiho; Watanabe, Yuji; Koide, Shuhei; Murai, Shin; Sorimachi, Yuriko; Fukuda, Yu; Sumiyama, Kenta; Sagara, Hiroshi; Nakano, Hiroyasu; Takubo, Keiyo; Iwama, Atsushi; Yamashita, Masayuki

Cadmium targeting MLKL-Drp1 axis to trigger mitochondrial oxidative stress contributes to necroinflammation in rat kidney

镉靶向MLKL-Drp1轴触发线粒体氧化应激,导致大鼠肾脏坏死性炎症。

Cai-Yu Lian,Wei-Hao Xia,Ming-Cheng Sun,Xue-Mei Wan,Xue-Lei Zhou,Lin Wang

MLKL in liver parenchymal cells promotes liver cancer in murine metabolic dysfunction-associated steatotic liver disease.

MLKL 在肝实质细胞中促进小鼠代谢功能障碍相关脂肪肝疾病中的肝癌发生。

Imerzoukene Ghiles, Kara-Ali Ghania Hounana, Heitz-Marchaland Céline, Larcher Thibaut, Simoes Eugénio Mélanie, Hamon Annaïg, Bidon Aurore, Ghukasyan Gevorg, Dubreil Laurence, Loiseau Nicolas, Dion Sarah, Raguenes-Nicol Céline, Piquet-Pellorce Claire, Samson Michel, Dimanche-Boitrel Marie-Thérèse, Le Seyec Jacques

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis.

MLKL 的缺失会减弱平滑肌细胞坏死,从而损害腹主动脉瘤的发展。

Nemade Harshal, Mehrkens Dennis, Lottermoser Hannah Sophia, Yilmaz Zeynep Ece, Mader Julian, Schelemei Patrik, Picard Felix Ruben, Geißen Simon, Schwab Gülsah Fülgen, Hoyer Friedrich Felix, Guthoff Henning, Hof Alexander, Nettersheim Felix Sebastian, Sachinidis Agapios, Gerdes Norbert, Sengle Gerhard, Winkels Holger, Baldus Stefan, Pasparakis Manolis, Mollenhauer Martin, Adam Matti

USP39 inhibits MLKL phosphorylation and deubiquitination to suppress necroptosis of nucleus pulposus cells and attenuate intervertebral disc degeneration.

USP39 抑制 MLKL 磷酸化和去泛素化,从而抑制髓核细胞坏死,减轻椎间盘退变。

RIP3 and MLKL regulate ER stress in alcohol-associated liver disease and pharmacological ER stress models: Insights beyond necroptosis

RIP3 和 MLKL 在酒精相关性肝病和药物诱导的内质网应激模型中调控内质网应激:超越坏死性凋亡的见解

Arya, Rakesh K; Huang, Emily; McMullen, Megan R; Poulsen, Kyle L; Wu, Jianguo; Travers, Jared; Paouri, Evi; Davalos, Dimitrios; Nagy, Laura E

Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis

肝脏中MLKL过表达诱导的坏死性凋亡会引发细胞衰老,并导致慢性炎症和纤维化。

Selvarani, Ramasamy; Lee, Sunho; Saminathan, Mani; Boovalingam, Puvarajan; Kurup, Kavitha; Pham, Kevin; Wolf, Roman F; Freeman, Willard M; Unnikrishnan, Archana; Richardson, Arlan

Baicalin Augments 5-Fluorouracil Efficacy in Colorectal Cancer by Triggering MLKL-Dependent Necroptosis: A Novel Strategy to Overcome Chemoresistance

黄芩苷通过触发MLKL依赖性坏死性凋亡增强5-氟尿嘧啶在结直肠癌中的疗效:一种克服化疗耐药性的新策略

Yuan, Jingwen; Peng, Zhiying; Wen, Rongbo; Zhou, Leqi; Cao, Fuao; Zhang, Tianshuai; Wu, Yingjie; Wu, Jiayue; Lin, Ran; Yu, Guanyu; Zhang, Wei

Targeting MLKL-Driven Necroptosis: A Therapeutic Target in Inflammation and Host Defense

靶向MLKL驱动的坏死性凋亡:炎症和宿主防御中的治疗靶点

Saha, Sarmistha; Saso, Luciano; Buttari, Brigitta

Cell death mechanisms in heat stroke and sepsis: ZBP1 and caspase-11 as molecular sensors driving the MLKL/GSDMD death execution axis

中暑和脓毒症中的细胞死亡机制:ZBP1 和 caspase-11 作为驱动 MLKL/GSDMD 死亡执行轴的分子传感器

Qin, Xiao-Jie; Luo, Cai-Shen; Li, Qi-Qi; Zhong, Biao-Chao; Wei, Qian-Tong; Zeng, Chun-Hui; Yang, Ke