日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTAP Loss Is Frequent in Oncogene-Driven NSCLC and May Confer Sensitivity to Combined PRMT5 Inhibitors and Targeted Therapies

MTAP缺失在癌基因驱动的非小细胞肺癌中很常见,并可能使肿瘤对PRMT5抑制剂和靶向治疗联合治疗敏感。

Aldea, M; Lenahan, S; Locquet, M-A; Liao, L; Gasparro, M; Gokhale, P C; Ghigna, M-R; Ionescu, D N; Odintsov, I; Ngo, K; Wang, X; Aziz, S; Pecci, F; Garbo, E; Ivanova, E; Nakazawa, S; Kulesza, J; Tsai, J A; Zullo, L; Lee, J; Zielinska, M; Simon, S; Han, D; Marinello, A; Li, G; Rossato de Almeida, G; Huang, J; Paoloni, F; Gariazzo, E; Santo, V; Remon, J; Marks, J A; LoPiccolo, J; Florez, N; Nishino, M; Ricciuti, B; Luo, J; Barbie, D A; Planchard, D; Rotow, J K; Barlesi, F; Graf, R P; Feng, W W; Besse, B; Paweletz, C; Sholl, L; Shaw, A T; Jänne, P A

MTAP Deletion in Oncogenesis: A Synthetic Lethality Scenario

MTAP缺失在肿瘤发生中的作用:一种合成致死情景

Rodon, Jordi; Johnson, Melissa L; George, Ben; Shah, Pooja A; Arbour, Kathryn C

The Diagnostic and Prognostic Role of Combined p16 and MTAP Immunohistochemistry in Melanocytic Tumors of Uncertain Malignant Potential: A Comprehensive Review and Clinical Practice Analysis

p16和MTAP联合免疫组化在恶性潜能未定的黑色素细胞肿瘤诊断和预后中的作用:一项综合综述和临床实践分析

Pepe, Ludovica; Fiorentino, Vincenzo; Pizzimenti, Cristina; Martini, Maurizio; Santarpia, Mariacarmela; Fazio, Antonina; Vaccaro, Mario; Lentini, Maria; Ieni, Antonio

Real-World Prevalence and Structural Validation of the Canonical 9p21 MTAP-CDKN2A/B Deletion in Non-NSCLC Solid Tumors

非小细胞肺癌实体瘤中典型 9p21 MTAP-CDKN2A/B 缺失的真实世界患病率和结构验证

Han, Miran; Lee, Eunbyeol; Shin, Ji Eun; Kwon, Minsuk; Hong, Jung Yong; Kim, Seung Tae; Ahn, Soomin; Kim, Kyoung-Mee; Lee, Jeeyun; Lim, Sung Hee

PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors

PRMT5在MTAP缺陷型恶性周围神经鞘瘤中经常上调,是潜在的治疗靶点。

Wang, Dingxun; Fishel, Melissa L; Samiei, Azadeh; Gampala, Silpa; Hu, Changdeng; Chen, Shaoxiong; Zhang, GuangJun

Prevalence and Actionability of MTAP Loss in Oncogene-Driven Lung Cancer

MTAP缺失在癌基因驱动的肺癌中的普遍性和可操作性

Sakai, Takashi; Piotrowska, Zofia; Wang, Charlotte I; Yeap, Beow Y; Heist, Rebecca S; Lin, Jessica J; Highfield, Lauren E; Petersen, Jennifer L; Banwait, Mandeep; Liang, Joyce; Madhavan, Manisha; Hata, Aaron N; Mino-Kenudson, Mari; Dagogo-Jack, Ibiayi

CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer

CRISPR药物组合筛选鉴定出MTAP缺失型癌症的有效联合疗法

Knoll, Nikola; Masser, Sarah; Bordas, Blanka; Ebright, Richard Y; Li, Guangyan; Kesar, Devishi; Destefanis, Eliana; Kania, Nicholas; Rodriguez, Diego J; Jen, Jayu; Zagar, Sydney E; Mensah, Caleb; Chen, Zixin; Moffitt, Samuel J; Enakireru, Erhumuoghene M; He, Yao; Feng, Baomou; Chokshi, Mira K; Jin, Cyrus Y; Raghavan, Srivatsan; Sellers, William R; Mulvaney, Kathleen M

Combination of the MTA-Cooperative PRMT5 Inhibitor BMS-986504 and KRAS Inhibitors Is an Effective Treatment Strategy for MTAP-Deleted KRAS-Mutant Pancreatic Cancer

MTA 协同 PRMT5 抑制剂 BMS-986504 与 KRAS 抑制剂联合使用是治疗 MTAP 缺失 KRAS 突变型胰腺癌的有效策略

Drizyte-Miller, Kristina; Engstrom, Lars D; Klomp, Jeffrey A; Stalnecker, Clint A; Stamey, Addison G; Taylor, Khalilah E; Roach, Mallory K; Robb, Ryan; Waters, Laura M; Calinisan, Andrew; Degan, Seamus; Chang, Wen-Hsuan; Helu, Xousaen M; Nguyen, David; Baldelli, Elisa; Pierobon, Mariaelena; Petricoin, Emanuel F; Briere, David M; Hallin, Jill; Christensen, James G; Bryant, Kirsten L; Cox, Adrienne D; Olson, Peter; Der, Channing J

Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

蛋氨酸干预诱导PD-L1表达,从而增强MTAP缺失型骨肉瘤的免疫检查点治疗反应

Haoran Mu ,Qi Zhang ,Dongqing Zuo ,Jinzeng Wang ,Yining Tao ,Zhen Li ,Xin He ,Huanliang Meng ,Hongsheng Wang ,Jiakang Shen ,Mengxiong Sun ,Yafei Jiang ,Weisong Zhao ,Jing Han ,Mengkai Yang ,Zhuoying Wang ,Yu Lv ,Yuqin Yang ,Jing Xu ,Tao Zhang ,Liu Yang ,Jun Lin ,Feng Tang ,Renhong Tang ,Haiyan Hu ,Zhengdong Cai ,Wei Sun ,Yingqi Hua

MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models

MTA 协同 PRMT5 抑制剂在 MTAP 缺失的恶性周围神经鞘瘤模型中有效

Xiaochun Zhang #,Dana C Borcherding #,Minjie Zhang,Yang Lyu,Guangfeng Wang,Kevin He,Gorkem Oztosun,Ishita Sachdeva,Liuzhan Yang,Kuangying Yang,Alex Yuen,Heather DiBenedetto,Alice Tsai,Alan Huang,John P Maxwell,Kevin M Cottrell,Kimberly J Briggs,Angela C Hirbe