日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy

DNA介导的自组装氧化损伤放大器联合铜和MTH1抑制剂用于癌症治疗

Ren, Cui; Shi, Zhiyong; Zhang, Xiaowen; Yu, Xueer; Gao, Yang; Qi, Zhi; Chen, Yu; Wang, Yong

Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity

有丝分裂抑制剂MTH1 karonudib 可杀死上皮性卵巢癌细胞,且该作用与铂类药物敏感性无关。

Hurley, Rachel M; Wagner, Jill M; Kanakkanthara, Arun; Venkatachalam, Annapoorna; Deisinger, Aaron M; Correia, Cristina; Schneider, Paula A; Peterson, Kevin L; Macon, Elaine P; Heinzen, Ethan P; Sanjiv, Kumar; Hou, Xiaonan; Becker, Marc A; Maurer, Matthew J; Larson, Melissa C; Swisher, Elizabeth M; Li, Hu; Oberg, Ann L; Weroha, S John; Berglund, Ulrika Warpman; Helleday, Thomas; Kaufmann, Scott H; Hendrickson, Andrea E Wahner

Neutron and time-resolved X-ray crystallography reveal the substrate recognition and catalytic mechanism of human Nudix hydrolase MTH1

中子和时间分辨X射线晶体学揭示了人Nudix水解酶MTH1的底物识别和催化机制

Hirata, Keisuke; Fujimiya, Kana; Ostermann, Andreas; Schrader, Tobias E; Hiromoto, Takeshi; Goto, Masataka; Arimori, Takao; Hirano, Yu; Kusaka, Katsuhiro; Tamada, Taro; Nakamura, Teruya

Pharmacological inhibition of MutT homolog 1 (MTH1) in allergic airway inflammation as a novel treatment strategy.

药物抑制 MutT 同源物 1 (MTH1) 治疗过敏性气道炎症是一种新的治疗策略。

Clinical Significance of NUDT1 (MTH1) Across Cancer Types

NUDT1 (MTH1) 在各种癌症类型中的临床意义

Misiak, Radosław; Białkowski, Karol; Dondajewska, Ewelina

Topical MTH1 Inhibition Suppresses SKP2-WNT5a-Driven Psoriatic Hyperproliferation

局部应用MTH1抑制剂可抑制SKP2-WNT5a驱动的银屑病细胞过度增殖。

Bivik Eding, Cecilia; Köhler, Ines; Moparthi, Lavanya; Sjögren, Florence; Andersson, Blanka; Das, Debojyoti; Verma, Deepti; Scobie, Martin; Warpman Berglund, Ulrika; Enerbäck, Charlotta

Repurposing resveratrol for redox-mediated inhibition of MTH1 in breast cancer.

利用白藜芦醇通过氧化还原介导抑制乳腺癌中的 MTH1。

Taiyab Aaliya, Choudhury Arunabh, Haider Shaista, Rathi Aanchal, Hussain Afzal, Alajmi Mohamed F, Chakrabarty Anindita, Khan Faez Iqbal, Shamsi Anas, Hassan Md Imtaiyaz

Synthesis of 3-(arylamino) quinazoline-2,4(1H,3H)-dione derivatives via TBHP/I2: Molecular docking, MD simulation, DFT, and pharmacological evaluation as MTH1 inhibitors

通过 TBHP/I2 合成 3-(芳基氨基)喹唑啉-2,4(1H,3H)-二酮衍生物:分子对接、MD 模拟、DFT 计算及作为 MTH1 抑制剂的药理学评价

Karim, Moeid Goudarzi; Mehrdad, Morteza; Gheidari, Davood; Gheidari, Nazanin Zahra

Sequential release of MTH1 inhibitor and chemotherapeutic drug using a pH-sensitive polymeric delivery system induces apoptosis in human tongue squamous cell carcinoma CAL-27 cells in vitro

利用pH敏感型聚合物递送系统顺序释放MTH1抑制剂和化疗药物,可在体外诱导人舌鳞状细胞癌CAL-27细胞凋亡。

Bowen, Zhao; Cuicui, Yan; Haoran, Qi; Hongliang, Ma; Changsheng, Sun

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

利用 CeTEAM 将细胞药物靶标结合到下游药理学

Nicholas C K Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Seher Alam, Maria J Pires, Hannah Stigsdotter, Azita Rasti, Marie-France Langelier, Daniel Rehling, Adam Throup, Oryn Purewal-Sidhu, Matthieu Desroses, Jacob Onireti, Prasad Wakchaure, Ingrid Almlöf, Johan Boström, Luka Bevc, Gior