日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elevated ZNF704 expression is associated with poor prognosis of uveal melanoma and promotes cancer cell growth by regulating AKT/mTOR signaling

ZNF704表达升高与葡萄膜黑色素瘤预后不良相关,并通过调节AKT/mTOR信号通路促进癌细胞生长。

Jingting Luo #,Haowen Li #,Jingying Xiu,Jingyao Zeng,Zhaoxun Feng,Hanqing Zhao,Yang Li,Wenbin Wei

HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

HMGA1通过PI3K/mTOR信号通路增强帕博西尼在肝内胆管癌中的疗效

Zhipeng Li ,Huaxin Zhou ,Zhijia Xia ,Tong Xia ,Gang Du ,Strohmer Dorothee Franziska ,Xiaoming Li ,Xiangyu Zhai ,Bin Jin

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

mTORC2 募集和选择性磷酸化 Akt 的结构基础。

Taylor Martin S, Chen Maggie, Hancock Matthew, Wranik Maximilian, Miller Bryant D, O'Meara Timothy R, Palanski Brad A, Ficarro Scott B, Groendyke Brian J, Xiang Yufei, Kondo Kazuma T, Linde-Garelli Karen Y, Lee Michelle J, Mondal Dibyendu, Freund Daniel, Congreve Samantha, Matas Kaay, Hennink Maximiliaan, Xibinaku Kera, Valenstein Max L, van Eeuwen Trevor, Marto Jarrod A, Sali Andrej, Shi Yi, Gray Nathanael S, Sabatini David M, Chu Nam, Rogala Kacper B, Cole Philip A

Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination.

与癫痫相关的 FOXJ3 变异将 PTEN-mTOR 通路的转录程序与神经元分化和皮质分层联系起来。

Cheng Haw-Yuan, Liu Chen, Nien Chiao-Wen, Huang Hui-Chin, Zhao Hong-Jun, Nian Fang-Shin, Chen Chien, Custodio Helena Martins, Sisodiya Sanjay M, Lu Chien, Chen Hsin-Hung, Hsu Chih-Sin, Pi Wen-Chieh, Chu Chia-Chi, Hsu Jacob Shu-Jui, Chen Pei-Lung, Chang Fu-Pang, Tung Chien-Yi, Chou Shen-Ju, Alavi Shahryar, Houlden Henry, Chen Wei-Yi, Liu Yo-Tsen, Hou Pei-Shan, Tsai Jin-Wu

Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.

MTOR 中特定情境下的调控基因变异会抑制肺炎相关脓毒症中的中性粒细胞-T 细胞串扰。

Zhang Ping, MacLean Patrick, Jia Alicia, O'Neill Callum R, Allcock Alice, Prince Ethan, Ozcan Bora, Doll Roman M, Dyne Imogen, Cano-Gamez Kiki, Qin Hanyu, Wainwright Chloe, Scozzafava Giuseppe, Brown Andrew C, Davies James O J, Chong Amanda Y, Mentzer Alexander J, Burnham Katie L, Davenport Emma E, Knight Julian C

HSPA12A impairs lipophagy to exaggerate septic cardiomyopathy by promoting MTOR's competition against LC3-II in binding with PNPLA2.

HSPA12A 会损害脂质自噬,从而加剧脓毒症性心肌病,其机制是通过促进 MTOR 与 LC3-II 竞争与 PNPLA2 结合。

Li Yunfan, Liu Shijiang, Min Xinxu, Cheng Hao, Zhang Xiaojin, Liu Jiali, Xia Yudong, Wang Xiaohui, Jiang Guohua, Hao Ruijinling, Li Chuanfu, Liu Li, Kong Qiuyue, Ding Zhengnian

Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal biogenesis via non-canonical MTORC1 inactivation.

蛋白毒性应激通过非经典的 MTORC1 失活触发 TFEB 和 TFE3 介导的自噬和溶酶体生物合成。

Zhu Zhou, Yang Jing, Montefusco Sandro, Xia Siyu, Ou Jinhuan, Tong Haibo, Zeng Qingzhong, Xu Fengmei, Dai Lingyun, Sun Jichao, Xu Chengchao, Medina Diego Luis, Wang Jigang, Zhang Wei, Yang Chuanbin

Combined Photothermal and mTOR-Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple-Negative Breast Cancer.

光热疗法与 mTOR 靶向疗法相结合可克服免疫逃逸并增强转移性三阴性乳腺癌的检查点阻断疗效。

Zhao Yujie, Yu Jing, Wang Xin, Liu Xu, Zuo Fengli, Xu Tianyue, Tang Leyi, Xiong Ling, Li Li, Li Huifang, Chen Xiaoting, Yang Guang, Jing Jing, Liu Xiaowei

FBXO2-mediated KPTN ubiquitination promotes amino acid-dependent mTORC1 signaling and tumor growth.

FBXO2 介导的 KPTN 泛素化促进氨基酸依赖性 mTORC1 信号传导和肿瘤生长。

AE-MXene-modified titanium alloy promotes osseointegration by regulating the AMPK-MTOR-autophagy pathway in macrophage

AE-MXene改性钛合金通过调节巨噬细胞中的AMPK-MTOR-自噬通路促进骨整合

Chao, Rui; Sun, Lei; Xu, Xinyu; Liu, Zhan; Xu, Xinyi; Ren, Zhen; Chen, Xinwei; Xu, Weifeng; Chen, Xuzhuo; Hu, Ying; Zhang, Shanyong