日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells

发现两类结构不同的MUS81核酸酶抑制剂,可增强化疗对癌细胞的疗效

Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir

MUS81 inhibits cell proliferation and migration in breast cancer by promoting the expression of CDKN2A(p16(INK4a)).

MUS81 通过促进 CDKN2A(p16(INK4a)) 的表达来抑制乳腺癌细胞的增殖和迁移。

Xie Rong, Kong Deyu, Su Xinyu, Zhang Lixi, Wan Jinnan, Yan Yanhong

CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions

CIP2A介导SLX4/MUS81/XPF在有丝分裂中的募集,以修复复制应激诱导的DNA损伤

de Haan, Lauren; Dijt, Sietse J; García-López, Alejandro; Ruan, Dan; Martzios, Panagiotis; Bakker, Femke J; Everts, Marieke; Warner, Harry; Mol, Frank N; Chapman, J Ross; de Boer, H Rudolf; van de Kooij, Bert; Huis In 't Veld, Pim J; Vlijm, Rifka; van Vugt, Marcel A T M

Fine mapping highlights ITGAL and MUS81 loss‐of‐function mutations modulating recessive impacts in dairy cattle

精细定位突显了ITGAL和MUS81功能缺失突变对奶牛隐性遗传影响的调节作用。

Seidizadeh, Omid; Cairo, Andrea; Mancini, Ilaria; George, James N; Peyvandi, Flora; Duntsch, Laura; Jivanji, Swati; Lopdell, Thomas; Reynolds, Edwardo G M; Williams, Liam; Littlejohn, Mathew D

Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

宿主 3' 瓣状内切酶 Mus81 在共价闭合环状 DNA 形成过程中对修剪乙肝病毒松弛环状 DNA 的末端冗余起着关键作用

Hu Zhang, Quanxin Long, Yuanjie Liu, Alexander L Marchetti, Cheng-Der Liu, Ning Sun, Haitao Guo

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma.

协同抑制 CHK1 和 MUS81 以对抗高危神经母细胞瘤的复制应激抵抗。

Hilgert Elien, Van Neste Christophe, Bekaert Sarah-Lee, Martens Fien, Vanhauwaert Suzanne, Sanders Ellen, Verstraelen Peter, Risseeuw Martijn, Westerhout Ellen M, Grannetia Mark A, Van Calenbergh Serge, Van Roy Nadine, De Vos Winnok H, Wolthuis Rob W F, Speleman Frank, Depestel Lisa, Durinck Kaat

SRS2 is required for MUS81-dependent CO formation in zmm mutants.

在 zmm 突变体中,SRS2 是 MUS81 依赖性 CO 形成所必需的

Petiot Valentine, Chéron Floriane, White Charles I, Da Ines Olivier

Fine mapping highlights ITGAL and MUS81 loss‐of‐function mutations modulating recessive impacts in dairy cattle

精细定位突显了ITGAL和MUS81功能缺失突变对奶牛隐性遗传影响的调节作用。

Kishita, Kenji; Washiyama, Naoki; Takeuchi, Yuki; Hirano, Masahiro; Yamanaka, Ken; Ohashi, Yuko; Tsuda, Kazumasa; Okamoto, Kazuma; Duntsch, Laura; Jivanji, Swati; Lopdell, Thomas; Reynolds, Edwardo G M; Williams, Liam; Littlejohn, Mathew D

TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes

有丝分裂过程中 CDK1 对 TDP1 的磷酸化促进 MUS81 依赖性的 Top1-DNA 共价复合物的修复。

Srijita Paul Chowdhuri ,Benu Brata Das

DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells

DNA 修复蛋白 RAD52 是保护哺乳动物细胞中的 G-四链体所必需的

Shuo Liu, Zi Wang, Sameer Bikram Shah, Chia-Yu Chang, Michael Ai, Tran Nguyen, Rong Xiang, Xiaohua Wu