NAMPT相关文献与解析，生知库 | 链接生命科学的每一步

Hu Ruoci, Park Jooman, Qian Yanyu, Xiong Shaolei, Elsabbagh Ahmad Hamza, Chhikara Aditya, Fan Huailing, Shi Zuoxiao, Liu Lifeng, Li Yanhui, Song Zhenyuan, Mahmoud Abeer M, Chen Jiwang, Baur Joseph A, He Yanlin, Layden Brian T, Zhou Zhenqi, Xu Pingwen, Ong Sang-Ging, Wang Zilai, Jiang Yuwei

IL-3

IL-33

信号转导

Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer

烟酰胺N-甲基转移酶（NNMT）维持YAP依赖性干细胞样/间质性前列腺癌对NAMPT抑制的固有敏感性

期刊:International Journal of Biological Sciences

影响因子:10

doi:10.7150/ijbs.120532

Carreira, Ágata Sofia Assunção; Ciuffreda, Marianna; Thongon, Nathakan; Haughey, Charles M; Pickard, Adam; Eddie, Sharon L; Steele, Rebecca E; Cerri, Elena; Belli, Romina; Peroni, Daniele; Facen, Elisa; Caffa, Irene; Ghanem, Moustafa; Nencioni, Alessio; Lunardi, Andrea; Tebaldi, Toma; Mills, Ian G; Provenzani, Alessandro

Topical NAMPT activation restores mitophagic flux to rescue diabetic keratopathy via the NADâº/PINK1 pathway.

局部激活 NAMPT 可恢复线粒体自噬通量，通过 NADâ º/PINK1 通路挽救糖尿病性角膜病变。

期刊:Cell Communication and Signaling

影响因子:8.9

doi:10.1186/s12964-026-02784-5

Guo Qian, Huang Guannan, Li Wanting, Ma Yunjing, Liu Haini, Liu Zihao, Zhu Limin, Ma Lechong, Zhou Qingjun, Zhao Shaozhen

NAMPT overexpression enhances the regenerative potential of mesenchymal stromal cell-derived extracellular vesicles in experimental AKI.

NAMPT 过表达增强了间充质基质细胞衍生的细胞外囊泡在实验性 AKI 中的再生潜能。

期刊:Stem Cell Research & Therapy

影响因子:7.3

doi:10.1186/s13287-026-04928-3

Buelli Simona, Prioli Miranda Soares Michelle, Pezzotta Anna, Corna Daniela, Trionfini Piera, Perico Luca, Kosovari Melissa, Rota Cinzia, Remuzzi Giuseppe, Benigni Ariela, Morigi Marina, Imberti Barbara

Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma

抑制NAMPT靶向DNA损伤反应可增强TP53突变型套细胞淋巴瘤对烷化化疗的敏感性

期刊:Blood Advances

影响因子:7.1

doi:10.1182/bloodadvances.2025016765

Li, Na; Liu, Yicen; Zhang, Linna; Guo, Saisai; Wu, Zhihao; Xu, Yan; Yang, Ming; Kong, Jixia; Che, Yuxuan; Shao, Kun; Yang, Hong

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy

开发靶向多功能酶烟酰胺磷酸核糖转移酶 (NAMPT) 的 PROTAC 用于乳腺癌治疗

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.5c01827

Galli, Ubaldina; Moro, Marianna; Balestrero, Federica Carolina; Colombo, Giorgia; Koten, Marco; Roncaglio, Benedetta; Genazzani, Armando A; Aprile, Silvio; Massarotti, Alberto; Orsomando, Giuseppe; Pirali, Tracey; Grolla, Ambra A

NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis

NAMPT通过SIRT1-C/EBPβ-STEAP4-NRF2轴改善高脂饮食诱导的非酒精性脂肪性肝病（NAFLD）。

期刊:Journal of Molecular Cell Biology

影响因子:5.9

doi:10.1093/jmcb/mjaf045

Zhao, Jingwu; Li, Qinjin; Wang, Yi; Liu, Bingbing; Gui, Sisi; Zheng, Yazhen; Chen, Xiaodong

NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma

NAMPT抑制通过线粒体代谢重编程诱导铁死亡，从而增强胶质母细胞瘤的肿瘤免疫原性。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1721125

Zhao, Dongxu; Duan, Lin; Ren, Hang; Zhang, Hang; Zhang, Menghui; Liu, Zhuohang; Wang, Hailan; Lu, Wenxuan; Shi, Wenhan; Hou, Qingwang; Li, Tianxiao; Li, Ming

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

【关注事项】Visfatin/PBEF/Nampt 通过 NAMPT-MAPK (p38, ERK1/2)-NF-κB 信号通路诱导巨噬细胞产生 EMMPRIN 和 MMP-9。

期刊:International Journal of Molecular Medicine

影响因子:5.8

doi:10.3892/ijmm.2026.5794

Fan, Yuqi; Meng, Shu; Wang, Yue; Cao, Jiatian; Wang, Changqian

CD19(+)Ki67(+)B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis.

CD19(+)Ki67(+)B 细胞受 NAMPT 调控，是三阴性乳腺癌脑转移的关键调节因子。

期刊:Breast Cancer Research

影响因子:5.6

doi:10.1186/s13058-026-02251-6

Zhou Qiyi, Zhu Zhimin, Zhao Yuxin, Jing Di, Zhang Liyuan

ERÎ± activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness.

ERÎ±激活NAMPT/IL-33信号通路，增强米色细菌产热和代谢适应性。

Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer

烟酰胺N-甲基转移酶（NNMT）维持YAP依赖性干细胞样/间质性前列腺癌对NAMPT抑制的固有敏感性

Topical NAMPT activation restores mitophagic flux to rescue diabetic keratopathy via the NADâº/PINK1 pathway.

局部激活 NAMPT 可恢复线粒体自噬通量，通过 NADâ º/PINK1 通路挽救糖尿病性角膜病变。

NAMPT overexpression enhances the regenerative potential of mesenchymal stromal cell-derived extracellular vesicles in experimental AKI.

NAMPT 过表达增强了间充质基质细胞衍生的细胞外囊泡在实验性 AKI 中的再生潜能。

Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma

抑制NAMPT靶向DNA损伤反应可增强TP53突变型套细胞淋巴瘤对烷化化疗的敏感性

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy

开发靶向多功能酶烟酰胺磷酸核糖转移酶 (NAMPT) 的 PROTAC 用于乳腺癌治疗

NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis

NAMPT通过SIRT1-C/EBPβ-STEAP4-NRF2轴改善高脂饮食诱导的非酒精性脂肪性肝病（NAFLD）。

NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma

NAMPT抑制通过线粒体代谢重编程诱导铁死亡，从而增强胶质母细胞瘤的肿瘤免疫原性。

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

【关注事项】Visfatin/PBEF/Nampt 通过 NAMPT-MAPK (p38, ERK1/2)-NF-κB 信号通路诱导巨噬细胞产生 EMMPRIN 和 MMP-9。

CD19(+)Ki67(+)B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis.

CD19(+)Ki67(+)B 细胞受 NAMPT 调控，是三阴性乳腺癌脑转移的关键调节因子。

ERÎ± activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness.

ERÎ±激活NAMPT/IL-33信号通路，增强米色细菌产热和代谢适应性。

Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer

烟酰胺N-甲基转移酶（NNMT）维持YAP依赖性干细胞样/间质性前列腺癌对NAMPT抑制的固有敏感性

Topical NAMPT activation restores mitophagic flux to rescue diabetic keratopathy via the NADâº/PINK1 pathway.

局部激活 NAMPT 可恢复线粒体自噬通量，通过 NADâ º/PINK1 通路挽救糖尿病性角膜病变。

NAMPT overexpression enhances the regenerative potential of mesenchymal stromal cell-derived extracellular vesicles in experimental AKI.

NAMPT 过表达增强了间充质基质细胞衍生的细胞外囊泡在实验性 AKI 中的再生潜能。

Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma

抑制NAMPT靶向DNA损伤反应可增强TP53突变型套细胞淋巴瘤对烷化化疗的敏感性

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy

开发靶向多功能酶烟酰胺磷酸核糖转移酶 (NAMPT) 的 PROTAC 用于乳腺癌治疗

NAMPT improves high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) via the SIRT1-C/EBPβ-STEAP4-NRF2 axis

NAMPT通过SIRT1-C/EBPβ-STEAP4-NRF2轴改善高脂饮食诱导的非酒精性脂肪性肝病（NAFLD）。

NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma

NAMPT抑制通过线粒体代谢重编程诱导铁死亡，从而增强胶质母细胞瘤的肿瘤免疫原性。

[Expression of Concern] Visfatin/PBEF/Nampt induces EMMPRIN and MMP‑9 production in macrophages via the NAMPT‑MAPK (p38, ERK1/2)‑NF‑κB signaling pathway

【关注事项】Visfatin/PBEF/Nampt 通过 NAMPT-MAPK (p38, ERK1/2)-NF-κB 信号通路诱导巨噬细胞产生 EMMPRIN 和 MMP-9。

CD19(+)Ki67(+)B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis.

CD19(+)Ki67(+)B 细胞受 NAMPT 调控，是三阴性乳腺癌脑转移的关键调节因子。

Topical NAMPT activation restores mitophagic flux to rescue diabetic keratopathy via the NADâº/PINK1 pathway.