Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
具有家族性阿尔茨海默病 APPV717I 突变的异种移植人类 iPSC 衍生神经元揭示了与突触功能相关的失调转录组特征,并暗示 LINGO2 是一种疾病信号介质
期刊:Acta Neuropathologica
影响因子:9.3
doi:10.1007/s00401-024-02755-5
Wenhui Qu, Matti Lam, Julie J McInvale, Jason A Mares, Sam Kwon, Nelson Humala, Aayushi Mahajan, Trang Nguyen, Kelly A Jakubiak, Jeong-Yeon Mun, Thomas G Tedesco, Osama Al-Dalahmah, Syed A Hussaini, Andrew A Sproul, Markus D Siegelin, Philip L De Jager, Peter Canoll, Vilas Menon #, Gunnar Hargus #
信号转导
神经
阿尔茨海默症
FCM
IF
IHC-P
WB
Neuroscience
Human
NCAM1