ATG5相关文献与解析，生知库 | 链接生命科学的每一步

Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy.

一氧化氮供体通过抑制HMGB1-ATG5介导的内皮细胞自噬来减轻心脏骤停引起的血脑屏障损伤。

Duan Pengyu, Bi Yonghong, Feng Weiyu, Jin Zhehao, Meng Yao, Li Hangbing, Li Xiaoyan, Luo Lan, Zhao Xiangcheng, Zhang Bing

血脑屏障

ATG7 vs. ATG5: Distinct autophagy pathways shaping TGF-β signaling and endothelial function

ATG7 与 ATG5：不同的自噬通路影响 TGF-β 信号传导和内皮功能

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0335584

Singh, Aman; Peddi, Bharatsinai; Bhatt, Kriti S; Nguyen, Hien C; Singh, Krishna K

Editorial Expression of Concern: ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

编辑关注声明：ATG5可被DNA损伤剂诱导，并促进不依赖于自噬的有丝分裂灾难。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-57529-8

Maskey, Dipak; Yousefi, Shida; Schmid, Inès; Zlobec, Inti; Perren, Aurel; Friis, Robert; Simon, Hans-Uwe

ATG5 controls CD80 expression in B cells and shapes cognate CD4(+) T cell responses

ATG5 控制 B 细胞中 CD80 的表达，并影响相应的 CD4(+) T 细胞反应。

期刊:Autophagy

影响因子:14.3

doi:10.1080/15548627.2025.2507614

Passos, Ingredy; Zobel, Thomas; Münz, Christian; Peters, Anneli; Lünemann, Jan D

Actl6a regulates autophagy via Sox2-dependent Atg5 and Atg7 expression to inhibit apoptosis in spinal cord injury.

Actl6a 通过 Sox2 依赖的 Atg5 和 Atg7 表达来调节自噬，从而抑制脊髓损伤中的细胞凋亡。

期刊:Journal of Advanced Research

影响因子:13

doi:10.1016/j.jare.2025.01.038

Hao Jian, Yang Yubiao, Xie Li, Li Zhenhan, Ma Boyuan, Wang Bitao, Chen Jinyu, Zeng Zhi, Zhou Xianhu

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

ATG5 和膜 atg8 化在逆转录酶体组装和功能中的非经典作用

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.100928

Paddar, Masroor Ahmad; Wang, Fulong; Trosdal, Einar S; Hendrix, Emily; He, Yi; Salemi, Michelle R; Mudd, Michal; Jia, Jingyue; Duque, Thabata; Javed, Ruheena; Phinney, Brett S; Deretic, Vojo

ATG5

发表日期：2025

文献求助收藏

ATG5-dependent autophagy in Sertoli cells protects against cadmium-disrupted blood-testis barrier via perturbing CXCL2/CXCR2 axis.

Sertoli 细胞中 ATG5 依赖性自噬通过扰乱 CXCL2/CXCR2 轴来保护血睾屏障免受镉破坏。

期刊:Cell Biology and Toxicology

影响因子:5.9

doi:10.1007/s10565-025-10089-5

Li Hao, Hu Yi-Fan, Wang Xin-Run, Hong Jing-Wen, Zhang Zhi-Yang, Zou Yu-Hui, Cheng Xin-Yi, Luo Ye-Xin, Zhang Xu-Dong, Zhu Hua-Long, Xiong Yong-Wei, Chang Wei, Wang Hua, Yang Lan

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

ATG5的缺失会损害CD4+ T细胞的活化并促进抗肿瘤反应。

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2025.1284391

Carlos Plaza-Sirvent ，Clara Bessen ，Alisha W Bronietzki ，Katjana Klages ，Marc Schuster ，Jochen Huehn ，Ingo Schmitz

ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease.

ESRRA-ATG5介导的线粒体自噬增强精氨酸代谢，从而缓解糖尿病肾病。

UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination.

UBA1 通过靶向 ATG5 进行泛素化来抑制自噬，从而促进心脏肥大。

Nitric Oxide Donor Alleviates Cardiac Arrest Induced Blood Brain Barrier Injury by Inhibiting HMGB1-ATG5 Mediated Endothelial Autophagy.

一氧化氮供体通过抑制HMGB1-ATG5介导的内皮细胞自噬来减轻心脏骤停引起的血脑屏障损伤。

ATG7 vs. ATG5: Distinct autophagy pathways shaping TGF-β signaling and endothelial function

ATG7 与 ATG5：不同的自噬通路影响 TGF-β 信号传导和内皮功能

Editorial Expression of Concern: ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

编辑关注声明：ATG5可被DNA损伤剂诱导，并促进不依赖于自噬的有丝分裂灾难。

ATG5 controls CD80 expression in B cells and shapes cognate CD4(+) T cell responses

ATG5 控制 B 细胞中 CD80 的表达，并影响相应的 CD4(+) T 细胞反应。

Actl6a regulates autophagy via Sox2-dependent Atg5 and Atg7 expression to inhibit apoptosis in spinal cord injury.

Actl6a 通过 Sox2 依赖的 Atg5 和 Atg7 表达来调节自噬，从而抑制脊髓损伤中的细胞凋亡。

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

ATG5 和膜 atg8 化在逆转录酶体组装和功能中的非经典作用

ATG5-dependent autophagy in Sertoli cells protects against cadmium-disrupted blood-testis barrier via perturbing CXCL2/CXCR2 axis.

Sertoli 细胞中 ATG5 依赖性自噬通过扰乱 CXCL2/CXCR2 轴来保护血睾屏障免受镉破坏。

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

ATG5的缺失会损害CD4+ T细胞的活化并促进抗肿瘤反应。