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Zhou, Xiang; Han, Seungbin; Cebulla, Nadine; Haertle, Larissa; Steinhardt, Maximilian J; Schirmer, Daniel; Runau, Eva; Flamm, Leon; Terhorst, Calvin; Jähnel, Laura; Vogt, Cornelia; Nerreter, Silvia; Teufel, Eva; Stanojkovska, Emilia; Mersi, Julia; Munawar, Umair; Schindehütte, Magnus; Blum, Robert; Reinhold, Ann-Kristin; Scherf-Clavel, Oliver; Rittner, Heike L; Pham, Mirko; Rasche, Leo; Einsele, Hermann; Sommer, Claudia; Kortüm, K Martin

NOX1

发表日期：2023

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NOX1 inhibition sensitizes HCC cells to sorafenib and radiotherapy by modulating ROS-mediated programmed cell death

NOX1抑制剂通过调节ROS介导的程序性细胞死亡，使HCC细胞对索拉非尼和放射疗法更加敏感。

期刊:Acta Pharmacologica Sinica

影响因子:8.4

doi:10.1038/s41401-025-01623-6

Mu, Wei; Shi, Ya-Ge; Jian, Yu-Lun; Li, Lei; Zhou, Yan-Feng; Wang, Hui; Ge, Yang

ANKRD49 promotes the epithelial-mesenchymal transition of non-small cell lung cancer via the PKNOX1/TGF-Î²1/SMAD axis.

ANKRD49 通过 PKNOX1/TGF-β1/SMAD 轴促进非小细胞肺癌的上皮-间质转化。

期刊:Cancer Cell International

影响因子:6

doi:10.1186/s12935-026-04240-3

Yuan Meng, Qin Guang-Mei, Zhang Chu-Lin, Liu Chao-Feng, Liang Gang, Sun Jia, Wang Wei, Liu Kai-Yuan, Yu Bao-Feng, Wang Hai-Long, Pang Min

NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice.

NOX1/4 驱动乙醇喂养小鼠的肝脏铁和脂质失调、氧化还原失衡和炎症。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-026-42716-4

Yu Linna, He Tian, Zhang Pengli, Zhao Xueru, Xun Linting, Li Ruochang, Wan Ping

炎症/感染

NOX1

Immunology/Inflammation

炎症

发表日期：2026

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Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.

橙皮苷通过 NOX1 依赖性氧化应激增强胃癌细胞对顺铂的敏感性。

期刊:Biomedical Reports

影响因子:1.9

doi:10.3892/br.2025.2076

Zhu Wanjing, Li Qiyin, Ji Zhenglei, Wu Di, Chen Jingya, Zhao Yunli, Wu Huazhang

NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo.

NOX1 和 NPY1R 标记区域性结肠干细胞群，这些干细胞群在体内是癌症的起源。

期刊:Nature Cell Biology

影响因子:19.1

doi:10.1038/s41556-025-01763-1

Gasnier Maxime, Chen Tanysha Chi-Ying, Yada Swathi, Sagiraju Sowmya, Yoshikawa Yusuke, Perna Stefano, Lim Hui Yi Grace, Lee Bernett, Barker Nick

Emergence of NOX1/DUOX NADPH oxidases is a key feature of functional neutrophil reprogramming at the gut and lung barrier

NOX1/DUOX NADPH氧化酶的出现是肠道和肺屏障中功能性中性粒细胞重编程的关键特征。

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2025.103883

Ashish K Singh ，Maurice O'Mara ，Julie Drieu La Rochelle ，Noemie Therry ，Aurora D'Alessio ，John Baugh ，Ramya S Barre ，Misaki Matsumoto ，Aitor Nogales ，Luis Martínez-Sobrido ，Ulla G Knaus

Alleviation of accelerated diabetic atherogenesis in STZ-treated apoE/NOX1 DKO mice, apoE-/-/tg-EC-DHFR mice, and by folic acid

叶酸可缓解链脲佐菌素（STZ）处理的 apoE/NOX1 双敲除小鼠、apoE-/-/tg-EC-DHFR 小鼠以及糖尿病动脉粥样硬化加速的发生。

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2025.103570

Yixuan Zhang ,Ji Youn Youn ,Kai Huang ,Yuhan Zhang ,Hua Cai

Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy

人参皂苷Rg5通过抑制NOX1调节TLR4和BCL-2通路，从而减轻高尿酸血症肾病中的炎症、细胞凋亡和细胞焦亡。

期刊:Journal of Ginseng Research

影响因子:6.8

doi:10.1016/j.jgr.2025.03.009

Yu-Xin Zhang ，Hui Wan ，Guan-Yue Shan ，Jun-Ya Cheng ，Zhi-Cheng Gao ，Yi-Ying Liu ，Wen-Na Shi ，Zi-Jun Sun ，Hai-Jun Li

Redox Modulation in Hepatic Fibrosis: Translating NOX1/4 Inhibition to Therapy

肝纤维化中的氧化还原调控：将NOX1/4抑制转化为治疗

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27010158

Mansour, Ghaith K; Hajjar, Ahmad W; Marafini, Irene; Monteleone, Giovanni

Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

硼替佐米诱发的周围神经病变和PKNOX1基因的单核苷酸多态性

NOX1 inhibition sensitizes HCC cells to sorafenib and radiotherapy by modulating ROS-mediated programmed cell death

NOX1抑制剂通过调节ROS介导的程序性细胞死亡，使HCC细胞对索拉非尼和放射疗法更加敏感。

ANKRD49 promotes the epithelial-mesenchymal transition of non-small cell lung cancer via the PKNOX1/TGF-Î²1/SMAD axis.

ANKRD49 通过 PKNOX1/TGF-β1/SMAD 轴促进非小细胞肺癌的上皮-间质转化。

NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice.

NOX1/4 驱动乙醇喂养小鼠的肝脏铁和脂质失调、氧化还原失衡和炎症。

Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.

橙皮苷通过 NOX1 依赖性氧化应激增强胃癌细胞对顺铂的敏感性。

NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo.

NOX1 和 NPY1R 标记区域性结肠干细胞群，这些干细胞群在体内是癌症的起源。

Emergence of NOX1/DUOX NADPH oxidases is a key feature of functional neutrophil reprogramming at the gut and lung barrier

NOX1/DUOX NADPH氧化酶的出现是肠道和肺屏障中功能性中性粒细胞重编程的关键特征。

Alleviation of accelerated diabetic atherogenesis in STZ-treated apoE/NOX1 DKO mice, apoE-/-/tg-EC-DHFR mice, and by folic acid

叶酸可缓解链脲佐菌素（STZ）处理的 apoE/NOX1 双敲除小鼠、apoE-/-/tg-EC-DHFR 小鼠以及糖尿病动脉粥样硬化加速的发生。

Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy

人参皂苷Rg5通过抑制NOX1调节TLR4和BCL-2通路，从而减轻高尿酸血症肾病中的炎症、细胞凋亡和细胞焦亡。

Redox Modulation in Hepatic Fibrosis: Translating NOX1/4 Inhibition to Therapy

肝纤维化中的氧化还原调控：将NOX1/4抑制转化为治疗