日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Ergosterol as a natural modulator of intestinal cholesterol absorption via NPC1L1: an in silico insight into hypercholesterolemia

麦角甾醇通过NPC1L1作为肠道胆固醇吸收的天然调节剂：高胆固醇血症的计算机模拟研究

期刊:Frontiers in Bioinformatics
影响因子:3.9
doi:10.3389/fbinf.2026.1734995
Shenoy, Aparna G; Sureshkumar, Amrithesh; Ravi, Vishal; Raju, Rajesh; Rehman, Niyas
NPC1L1
NPC1
代谢
发表日期：2026
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Mechanistic Insights into Lactobacillus harbinensis and Other Probiotics Regulating Lipid Metabolism in T2DM Mice via the PPARγ-LXRα-NPC1L1 Signaling Pathway Based on Multi-Omics Analysis

基于多组学分析的哈尔滨乳杆菌及其他益生菌通过PPARγ-LXRα-NPC1L1信号通路调控2型糖尿病小鼠脂质代谢的机制研究

期刊:Metabolites
影响因子:3.7
doi:10.3390/metabo16030157
Yeerjiang, Baheban; Manaer, Tabusi; Liu, Xuelian; Bieerdimulati, Reziya; Nabi, Xinhua
NPC1L1
信号转导
NPC1
代谢
糖尿病
发表日期：2026
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Identification of a Novel NPC1L1 Inhibitor from Danshen and Its Role in Nonalcoholic Fatty Liver Disease

从丹参中鉴定出一种新型NPC1L1抑制剂及其在非酒精性脂肪肝疾病中的作用

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms26062793
Xia, Donghai; Jiang, Xuan; Xie, Xiaomin; Zhou, Han; Yu, Dongping; Jin, Gaowa; Ye, Xianlong; Zhu, Shenglong; Guo, Zhimou; Liang, Xinmiao
代谢
NPC1
NPC1L1
脂肪肝
发表日期：2025
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Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer

调控NPC1L1以增强PARP抑制剂诱导的三阴性乳腺癌细胞铁死亡和免疫反应

期刊:Pharmaceutics
影响因子:4.9
doi:10.3390/pharmaceutics17050554
Ge Li ，Yuxia Yuan ，Xinhua Wu ，Lixian Wu
免疫/内分泌
肿瘤
乳腺癌
巨噬细胞
NPC1
NPC1L1
铁死亡
发表日期：2025
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Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks

克隆、系统发育分析、组织表达谱分析以及NPC1L1在鸡、鹌鹑和鸭中的功能作用

期刊:Poultry Science
影响因子:4.2
doi:10.1016/j.psj.2025.105032
Shu, Xin; Chen, Ziwei; Wang, Hui; Xu, Bingjie; Liu, Li; Zhang, Jilong; Zheng, Xiaotong; Chen, Jianfei
NPC1L1
发育与干细胞
NPC1
发表日期：2025
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Dietary curcumin prevents hypercholesterolemia by inhibiting the transcriptional activity of SREBP-2 and HNF1α and reducing intestinal and hepatic NPC1L1 expression in high-fat diet-fed hamsters.

膳食姜黄素通过抑制 SREBP-2 和 HNF1α 的转录活性，并降低高脂饮食喂养的仓鼠肠道和肝脏中 NPC1L1 的表达，来预防高胆固醇血症。

期刊:Nutrition & Metabolism
影响因子:4.1
doi:10.1186/s12986-025-01031-x
Cao Zhuo, Yang Jie, Mai Haiyan, Hong Ting, Chen Xiaobing, Feng Dan
EBP
NF1
NPC1
NPC1L1
发表日期：2025
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Intestinal IL-25 prevents high-fat diet-induced obesity by modulating the cholesterol transporter NPC1L1 expression in the intestinal epithelial cells

肠道IL-25通过调节肠上皮细胞中胆固醇转运蛋白NPC1L1的表达来预防高脂饮食诱导的肥胖。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-95516-7
Jeerawattanawart, Siranart; Angkasekwinai, Pornpimon
代谢
肥胖
细胞生物学
NPC1
NPC1L1
IL-2
上皮细胞
发表日期：2025
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NPC1L1 on pancreatic adenocarcinoma cell functions as a two-pronged checkpoint against antitumor activity

胰腺腺癌细胞上的NPC1L1发挥着双重抗肿瘤活性检查点的作用

期刊:
影响因子:
doi:10.1016/j.xinn.2024.100783
Zi, Ruiyang; Shen, Kaicheng; Zheng, Pengfei; Su, Xingxing; Yang, Yishi; Chen, Yanrong; Dai, Haisu; Mao, Chengyi; Lu, Yongling; Wang, Liting; Ma, Hongbo; Wang, Wei; Li, Qingyun; Lu, Wei; Li, Chengtao; Zheng, Shuangjia; Shi, Hui; Liu, Xiaohong; Chen, Zhiyu; Liang, Houjie; Ou, Juanjuan
NPC1L1
肿瘤
肿瘤免疫
NPC1
细胞生物学
发表日期：2025
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Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease

NPC1L1和HMGCR基因多态性与早发性三支血管冠状动脉疾病患者冠状动脉钙化的相关性

期刊:BMC Medical Genomics
影响因子:2
doi:10.1186/s12920-024-01802-0
Li, Yulong; Li, Jiawen; Tang, Xiaofang; Xu, Jingjing; Liu, Ru; Jiang, Lin; Tian, Jian; Zhang, Yin; Wang, Dong; Sun, Kai; Xu, Bo; Zhao, Wei; Hui, Rutai; Gao, Runlin; Song, Lei; Yuan, Jinqing; Zhao, Xueyan
NPC1L1
NPC1
GCR
发表日期：2024
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NPC1L1 Plays a Novel Role in Nonalcoholic Fatty Liver Disease

NPC1L1在非酒精性脂肪肝疾病中发挥新作用

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.3c07337
Xu, ChongLi; Fu, Fengyang; She, Yuhan; Xu, ChongBo
代谢
NPC1
NPC1L1
脂肪肝
发表日期：2023
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