日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth

共价变构分子胶抑制NRF2依赖性癌症生长

Roy, Nilotpal; Wyseure, Tine; Lo, I-Chung; Lu, Justine; Eissler, Christie L; Bernard, Steffen M; Bok, Ilah; Snead, Aaron N; Parker, Albert; Lo, U-Ging; Green, Jason C; Inloes, Jordon; Jacinto, Sarah R; Kuenzi, Brent; Pariollaud, Marie; Negri, Kathleen; Le, Khoi; Horning, Benjamin D; Ibrahim, Noah; Grabow, Stephanie; Panda, Harit; Bhatt, Dhaval P; Wilkerson, Emily M; Saeidi, Soma; Zolkind, Paul; Rush, Zoe; Williams, Heather N; Walton, Eric; Pastuszka, Martha K; Sigler, John J; Tran, Eileen; Hee, Kenneth; McLaughlin, Joseph; Ambrus-Aikelin, Géza; Pollock, Jonathan; Abraham, Robert T; Kinsella, Todd M; Simon, Gabriel M; Major, Michael B; Weinstein, David S; Patricelli, Matthew P

Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells

过量的半胱氨酸会促进结合物的形成,并抑制NRF2激活的癌细胞增殖。

Brain, Jennifer A; Vigil, Anna-Lena B G; Davidsen, Kristian; Itokawa, Ayaha; Jurasin, Abby C; Kerbyson, Hannah J; Kobiesa, Maximilian; Hart, Madeleine L; Yoon, Sang Jun; Bellotti, Peter; Maianti, Juan Pablo; DeNicola, Gina M; Sullivan, Lucas B

Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response.

二甲双胍通过 NRF2 介导的 IRE1α 依赖性未折叠蛋白反应的恢复来缓解与衰老相关的牙周炎。

Sun Yu, Chen Qifeng, Zhao Yan, Yin Yuanyuan, Chen Qiao, Yang Lixin, Liu Zixuan, Chen Rui, Xu Xiaohui, Song Jinlin

Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy.

KEAP1/NRF2 介导的差异性信号传导拓宽了小细胞肺癌治疗中氧化还原靶向药物的治疗窗口。

Samarin Jana, Nůsková Hana, Fabrowski Piotr, Malz Mona, Amtmann Eberhard, Taeubert Minerva J, Pastor-Flores Daniel, Kazdal Daniel, Kurilov Roman, de Vries Nicole, Pink Hannelore, Deis Franziska, Hummel-Eisenbeiss Johanna, Renz Lisa, Kaushal Kamini, Morgen Michael, Dick Tobias P, Hamilton Gerhard, Muckenthaler Martina, Mall Moritz, Lim Bryce, Kanamaru Taishi, Klinke Glynis, Sos Martin L, Frede Julia, Miller Aubry K, Alborzinia Hamed, Gunkel Nikolas

ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling.

ERM抑制通过ROS诱导的NRF2信号传导赋予铁死亡抵抗力。

Qiao Menghao, Zhou Liqun, Zhou Minhua, Fang Yu, Mai Haiying, Cao Lingbo, Xu Kun, Sang Yuan, Chen Minyi, Huang Jiewei, Huang Peiyi, Yan Zhipeng, Wang Chao, Dai Zhangshuai, Huang Dichun, He Ronghan, Pang Lijuan, Guo Yunmiao, Chew Ting Gang, Huang Junqi

Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1.

Tussilagone 通过直接靶向 KEAP1 的半胱氨酸 434 来调节 Nrf2 和 NF-κB/NLRP3 炎症小体,从而减轻香烟烟雾引起的慢性阻塞性肺病。

Targeting of a novel interplay between MET tyrosine kinase and NRF2 enhances sensitivity to Paclitaxel in triple negative breast cancer

靶向MET酪氨酸激酶和NRF2之间的新型相互作用可增强三阴性乳腺癌对紫杉醇的敏感性

Taddei, Irene; Cirotti, Claudia; Lamballe, Fabienne; Castellanet, Olivier; Maina, Flavio; Medici, Vanessa; Fierro, Fabrizio; Corleone, Giacomo; De Nicola, Francesca; Fanciulli, Maurizio; Cesari, Eleonora; Di Leone, Alba; Piermattei, Alessia; Santoro, Angela; Naro, Chiara; Sette, Claudio; Barilà, Daniela

Curcuma longa-derived extracellular vesicle-like particles ameliorate retinal neovascularization through HIF-1α and NRF2 signaling

姜黄来源的细胞外囊泡样颗粒通过HIF-1α和NRF2信号通路改善视网膜新生血管形成

Chen, Ying; Peng, De-Wei; Jiang, Sheng-Rui; Shao, Qian-Chun; Zhang, Yi-Cong; Chi, Zai-Long

NRF2 activation resolves neuropathic pain via dual antioxidant and Na(V)1.7-Suppressive mechanisms.

NRF2 激活通过双重抗氧化和 Na(V)1.7 抑制机制缓解神经性疼痛。

Shan Zhiming, Cai Song, Yang Haoyi, Guo Weijie, Wu Chaoran, Cheung Martin, Luo Xin, Cheung Chi Wai, Liu Jessica Aijia

Sex-based differences in the NRF2 oxidative stress response: Implications for precision therapeutics

NRF2氧化应激反应中的性别差异:对精准治疗的启示

Russomanno, Giusy; Kwiatkowska, Karolina; Copple, Ian M