日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ODBAE: a high-performance model identifying complex phenotypes in high-dimensional biological datasets

ODBAE:一种用于识别高维生物数据集中的复杂表型的高性能模型

Shen, Yafei; Zhang, Tao; Liu, Zhiwei; Kostelidou, Kalliopi; Xu, Ying; Yang, Ling

Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells

支链 α-酮酸在有氧条件下激活血管细胞中的 HIF1α 信号

Wusheng Xiao, Nishith Shrimali, William M Oldham, Clary B Clish, Huamei He, Samantha J Wong, Bradley M Wertheim, Elena Arons, Marcia C Haigis, Jane A Leopold, Joseph Loscalzo

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

BCKDK 变构抑制剂脱靶消耗血浆色氨酸

Caitlyn E Bowman, Michael D Neinast, Cholsoon Jang, Jiten Patel, Megan C Blair, Emily T Mirek, William O Jonsson, Qingwei Chu, Lauren Merlo, Laura Mandik-Nayak, Tracy G Anthony, Joshua D Rabinowitz, Zolt Arany

Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance

肌肉中的支链氨基酸分解代谢影响全身 BCAA 水平,但不影响胰岛素抵抗

Megan C Blair, Michael D Neinast, Cholsoon Jang, Qingwei Chu, Jae Woo Jung, Jessie Axsom, Marc R Bornstein, Chelsea Thorsheim, Kristina Li, Atsushi Hoshino, Steven Yang, Rachel J Roth Flach, Bei B Zhang, Joshua D Rabinowitz, Zoltan Arany

Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors

结构研究发现,血管紧张素II受体阻滞剂样化合物是支链酮酸脱氢酶激酶抑制剂。

Shenping Liu ,Bethany L Kormos ,John D Knafels ,Parag V Sahasrabudhe ,Amy Rosado ,Ruth F Sommese ,Allan R Reyes ,Jessica Ward ,Rachel J Roth Flach ,Xiaochun Wang ,Leanne M Buzon ,Matthew R Reese ,Samit K Bhattacharya ,Kiyoyuki Omoto ,Kevin J Filipski

Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure

心脏外 BCAA 分解代谢可降低血压并预防心力衰竭

Danielle Murashige, Jae Woo Jung, Michael D Neinast, Michael G Levin, Qingwei Chu, Jonathan P Lambert, Joanne F Garbincius, Boa Kim, Atsushi Hoshino, Ingrid Marti-Pamies, Kendra S McDaid, Swapnil V Shewale, Emily Flam, Steven Yang, Emilia Roberts, Li Li, Michael P Morley, Kenneth C Bedi Jr, Matthew

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

靶向 BCAT1 与 α-酮戊二酸联合作用可引发胶质母细胞瘤的代谢合成致死

Bo Zhang #, Hui Peng #, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E Wang, Yanling Niu, Yan Chen, Yijie Wang, Kimmo J Hatanpaa, John A Copland, Ralph J DeBerardinis, Yingfei Wang, Weibo Luo

Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry

对中美洲血统的枫糖尿病患者 DBT 中反复观察到的变异进行基因组和生化分析

Charles J Billington Jr, Kimberly A Chapman, Eyby Leon, Beatrix W Meltzer, Seth I Berger, Matthew Olson, Robert A Figler, Steve A Hoang, Cui Wanxing, Brian R Wamhoff, M Sol Collado, Kristina Cusmano-Ozog

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

致癌过程中 BCAA 分解代谢的丧失会增强 mTORC1 活性并促进肿瘤发展和进展

Russell E Ericksen, Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Phillip J White, Zhaobing Ding, Royston Kwok, Philip Lee, George K Radda, Han Chong Toh, Matthew D Hirschey, Weiping Han

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

支链氨基酸的全身代谢命运的定量分析

Michael D Neinast, Cholsoon Jang, Sheng Hui, Danielle S Murashige, Qingwei Chu, Raphael J Morscher, Xiaoxuan Li, Le Zhan, Eileen White, Tracy G Anthony, Joshua D Rabinowitz, Zoltan Arany