OPRM相关文献与解析，生知库 | 链接生命科学的每一步

Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia

OPRM1 过度甲基化：肌痛性脑脊髓炎/慢性疲劳综合征和纤维肌痛中内源性阿片通路失调

期刊:International Journal of Molecular Sciences

doi:10.3390/ijms27020826

Wyns, Arne; Hendrix, Jolien; Van Campenhout, Jente; Buntinx, Yanthe; Xiong, Huan-Yu; De Bruyne, Elke; Godderis, Lode; Nijs, Jo; Rice, David; Chiang, Daniel; Polli, Andrea

OPRM1 gene polymorphism linked to anxiety in cancer-related pain patients: an observational study

OPRM1基因多态性与癌症相关疼痛患者的焦虑有关：一项观察性研究

期刊:Frontiers in Pain Research

影响因子:2.7

doi:10.3389/fpain.2026.1666510

Mo, Jianwen; Xie, Zhuolun; Li, Xiaolan; Hu, Lei; Chen, Min; Xia, Xiaolin; Wang, Wei

Erratum: Pain Intensity in Patients with Opioid Use Disorder on Extended-Release Naltrexone or Opioid Agonists; The Role of COMT rs4680 and OPRM1 rs1799971: An Exploratory Study [Corrigendum]

勘误：阿片类药物使用障碍患者使用缓释纳曲酮或阿片类激动剂治疗时的疼痛强度；COMT rs4680 和 OPRM1 rs1799971 的作用：一项探索性研究 [更正]

期刊:Journal of Pain Research

影响因子:2.5

doi:10.2147/JPR.S598098

Genetic Variation A118G in the OPRM1 Gene Underlies the Dimorphic Response to Epidural Opioid-Induced Itch

OPRM1基因中的A118G遗传变异是硬膜外阿片类药物诱发瘙痒的二态性反应的基础。

期刊:Neuroscience Bulletin

影响因子:5.8

doi:10.1007/s12264-025-01411-6

Zhou, Xiaomeng; Li, Ai-Lun; Du, Wan-Jie; Gao, Pengyu; Lai, Bin; Fang, Fang; Han, Qingjian; Cang, Jing

OPRM

发表日期：2025

文献求助收藏

Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (OPRM1) rs1799971 and Catechol-O-Methyltransferase (COMT) rs4680, with Phenotypic Expression of Fibromyalgia

遗传变异（例如μ-阿片受体1 (OPRM1) rs1799971 和儿茶酚-O-甲基转移酶 (COMT) rs4680）与纤维肌痛表型表达的关联

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines13051183

Erenas Ondategui, Isabel; Gómez Castro, Julia; Estepa Hernández, Sandra; Chicharro Miguel, Celia; Peiró Cárdenas, Regina; Fernández-Araque, Ana; Verde, Zoraida

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder

手术后持续使用阿片类药物的遗传关联研究表明，OPRM1基因而非其他阿片类药物相关基因位点是阿片类药物使用障碍的主要驱动因素。

期刊:Genetic Epidemiology

影响因子:3.8

doi:10.1002/gepi.22588

Annis, Aubrey C; Gunaseelan, Vidhya; Smith, Albert V; Abecasis, Gonçalo R; Larach, Daniel B; Zawistowski, Matthew; Frangakis, Stephan G; Brummett, Chad M

OPRM

发表日期：2025

文献求助收藏

Do Diabetes and Genetic Polymorphisms in the COMT and OPRM1 Genes Modulate the Postoperative Opioid Demand and Pain Perception in Osteoarthritis Patients After Total Knee and Hip Arthroplasty?

糖尿病和 COMT 及 OPRM1 基因的遗传多态性是否会影响骨关节炎患者在全膝关节和髋关节置换术后的阿片类药物需求和疼痛感知？

期刊:Journal of Clinical Medicine

影响因子:2.9

doi:10.3390/jcm14134634

Jurewicz, Alina; Gasiorowska, Agata; Leźnicka, Katarzyna; Maciejewska-Skrendo, Agnieszka; Pawlak, Maciej; Machoy-Mokrzyńska, Anna; Bohatyrewicz, Andrzej; Tarnowski, Maciej

MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury.

周围神经损伤后，MBD1 依赖性 SUV39h1 募集诱导背根神经节中 Oprm1 的 H3K9me3 介导的转录沉默。

期刊:Molecular Pain

影响因子:2.8

doi:10.1177/17448069251389416

Sheng Hengwei, Gong Hualei, Liu Xiaolin, Wu Wenbo, Silva Helena Soares da, Huang Sen, Mo Kai

Correction to "ABCB1, SLC22A1, COMT, and OPRM1 Genotypes: Study of Their Influence on Plasma Methadone Levels and Clinical Response to Methadone Maintenance Treatment in Opioid Use Disorder"

对“ABCB1、SLC22A1、COMT 和 OPRM1 基因型：研究其对阿片类药物使用障碍患者血浆美沙酮水平和美沙酮维持治疗临床反应的影响”一文的更正

期刊:Fundamental & Clinical Pharmacology

影响因子:2.5

doi:10.1111/fcp.70040

OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism.

OPRM1/MRGPRX1 异二聚体通过外周机制驱动阿片类药物引起的瘙痒。

Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia

OPRM1 过度甲基化：肌痛性脑脊髓炎/慢性疲劳综合征和纤维肌痛中内源性阿片通路失调

OPRM1 gene polymorphism linked to anxiety in cancer-related pain patients: an observational study

OPRM1基因多态性与癌症相关疼痛患者的焦虑有关：一项观察性研究

Erratum: Pain Intensity in Patients with Opioid Use Disorder on Extended-Release Naltrexone or Opioid Agonists; The Role of COMT rs4680 and OPRM1 rs1799971: An Exploratory Study [Corrigendum]

勘误：阿片类药物使用障碍患者使用缓释纳曲酮或阿片类激动剂治疗时的疼痛强度；COMT rs4680 和 OPRM1 rs1799971 的作用：一项探索性研究 [更正]

Genetic Variation A118G in the OPRM1 Gene Underlies the Dimorphic Response to Epidural Opioid-Induced Itch

OPRM1基因中的A118G遗传变异是硬膜外阿片类药物诱发瘙痒的二态性反应的基础。

Association of Genetic Variants, Such as the μ-Opioid Receptor 1 (OPRM1) rs1799971 and Catechol-O-Methyltransferase (COMT) rs4680, with Phenotypic Expression of Fibromyalgia

遗传变异（例如μ-阿片受体1 (OPRM1) rs1799971 和儿茶酚-O-甲基转移酶 (COMT) rs4680）与纤维肌痛表型表达的关联

Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder

手术后持续使用阿片类药物的遗传关联研究表明，OPRM1基因而非其他阿片类药物相关基因位点是阿片类药物使用障碍的主要驱动因素。

Do Diabetes and Genetic Polymorphisms in the COMT and OPRM1 Genes Modulate the Postoperative Opioid Demand and Pain Perception in Osteoarthritis Patients After Total Knee and Hip Arthroplasty?

糖尿病和 COMT 及 OPRM1 基因的遗传多态性是否会影响骨关节炎患者在全膝关节和髋关节置换术后的阿片类药物需求和疼痛感知？

MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury.

周围神经损伤后，MBD1 依赖性 SUV39h1 募集诱导背根神经节中 Oprm1 的 H3K9me3 介导的转录沉默。

Correction to "ABCB1, SLC22A1, COMT, and OPRM1 Genotypes: Study of Their Influence on Plasma Methadone Levels and Clinical Response to Methadone Maintenance Treatment in Opioid Use Disorder"

对“ABCB1、SLC22A1、COMT 和 OPRM1 基因型：研究其对阿片类药物使用障碍患者血浆美沙酮水平和美沙酮维持治疗临床反应的影响”一文的更正