日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

mTORC2 募集和选择性磷酸化 Akt 的结构基础。

Taylor Martin S, Chen Maggie, Hancock Matthew, Wranik Maximilian, Miller Bryant D, O'Meara Timothy R, Palanski Brad A, Ficarro Scott B, Groendyke Brian J, Xiang Yufei, Kondo Kazuma T, Linde-Garelli Karen Y, Lee Michelle J, Mondal Dibyendu, Freund Daniel, Congreve Samantha, Matas Kaay, Hennink Maximiliaan, Xibinaku Kera, Valenstein Max L, van Eeuwen Trevor, Marto Jarrod A, Sali Andrej, Shi Yi, Gray Nathanael S, Sabatini David M, Chu Nam, Rogala Kacper B, Cole Philip A

ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation

ARP2/3复合物通过mTORC1和mTORC2过度激活,介导PTEN缺陷型人类神经细胞的神经病理学变化。

Dhaliwal, Navroop K; Weng, Octavia Yifang; Tian, Ai; Aggarwal, Aditi; Ahmed, Mai; Sun, Guoria; Bhattacharya, Afrin; Choi, Wendy W Y; Nishimura, Haruka; Chakraborty, Pragnya; Dong, Xiaoxue; Wu, Yuncheng; Wilson, Michael D; Wang, Lu-Yang; Parada, Luis F; Muffat, Julien; Li, Yun

The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy

mTORC2组分SIN1在转录后水平调控TYMS水平,并响应5-FU化疗调节P53活性。

Sayed, Abdulrahman El; Gomes, Nelson; Zakrzewski, Maciej; Liudkovska, Vladyslava; Serwa, Remigiusz; Azzi, Abdelhalim

Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway

Liprin-α1通过激活mTORC2-AKT1通路增强PHLDB3在结直肠癌中的致癌功能。

Ko, Hyun Min; Cao, Bo; Li, Li; Park, Hee-Won; Zeng, Shelya X; Lu, Hua

mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration

mTORC1 和 mTORC2 在人类神经发育、疾病和再生中的协同作用

Dhaliwal, Navroop K; Muffat, Julien; Li, Yun

TAX1BP1 protects against doxorubicin-induced cardiotoxicity via maintaining mitochondrial function in a mTORC2-SGK1-VDAC1 manner.

TAX1BP1 通过 mTORC2-SGK1-VDAC1 的方式维持线粒体功能,从而保护心脏免受阿霉素引起的毒性作用。

Xu Haixia, Lin Dejian, Dai Xinqing, Zhang Jian, Shi Jiayu, Lu Qi, Gu Zhifeng

PTEN-mTORC2 signaling module controls antibody isotype selection and antiviral humoral immunity

PTEN-mTORC2信号通路模块控制抗体亚型选择和抗病毒体液免疫

Thapa, Bikash; Lee, Yejin; Pak, Seongwon; Kim, Dongkyu; Kwon, Hyung-Joo; Lee, Keunwook

PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2-PKCα pathway in Sertoli cells.

PTBP1 通过促进支持细胞中 mTORC2-PKCα 通路的细胞骨架组织来支持小鼠精子发生。

Ozawa Manabu, Taguchi Jumpei, Mori Hideto, Kikuchi Mio, Muratani Masafumi, Yamamoto Takuya, Yamada Yasuhiro, Yoshida Nobuaki, Ikawa Masahito

FAM64A Potentiates Bladder Carcinoma Tumorigenesis and Metastasis Through PI3K/mTORC2/AKT Pathway Activation

FAM64A通过激活PI3K/mTORC2/AKT通路增强膀胱癌的肿瘤发生和转移

Zhu, Tao; Liufu, Cen; Yin, Cong; He, Jinqing; Luo, Junhua; Shi, Bentao; Wang, Yan

Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB

mTORC2激活蛋白激酶AKT/PKB的结构和机制基础

Chu, Nam; Le, Nhat; Nebie, Ouada; Yang, Sammi