日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

OTUD4 deubiquitination stabilizes EGFR and activates the PI3K/AKT pathway to promote the invasiveness of triple-negative breast cancer.

OTUD4 去泛素化可稳定 EGFR 并激活 PI3K/AKT 通路，从而促进三阴性乳腺癌的侵袭性。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-026-08482-x
Ren Yu, Zhou Fulin, Tan Zhihua, Yang Senguo, Zhang Shaolin, Zhang Yonglin, Fu Yumei, Zhang Mai, Liu Shu
肿瘤
表观遗传
OTUD4
肿瘤免疫
信号转导
泛素化
EGF
乳腺癌
EGFR
AKT
发表日期：2026
文献求助 收藏

OTUD4-ZMYND8-DDX3X Axis Drives Immunosuppressive Microenvironment in Spinal Metastases of Triple-Negative Breast Cancer

OTUD4-ZMYND8-DDX3X轴驱动三阴性乳腺癌脊柱转移瘤的免疫抑制微环境

期刊:Neoplasia
影响因子:7.7
doi:10.1016/j.neo.2025.101259
Liang, Bing; Hu, Annan; Lu, Hongwei; Zhou, Hao; Chen, Qing; Jia, Chao; Wang, Jinjin; Jiang, Libo; Hong, Wei; Zhou, Jian; Dong, Jian
肿瘤
ZMYND8
OTUD4
肿瘤免疫
DDX3
乳腺癌
免疫/内分泌
发表日期：2026
文献求助 收藏

OTUD4 regulates pancreatic cancer progression via Hippo/YAP axis.

OTUD4 通过 Hippo/YAP 轴调控胰腺癌的进展。

期刊:Neoplasia
影响因子:7.7
doi:10.1016/j.neo.2026.101285
Qu Shuaike, Liu Zhihao, Wang Beibei, Li Xin, Li Zhongbo, Gai Yingwen, Sun Yanan, Zhang Qi, Sun Yaguang, Pan Wei, Zhu Jian, Tan Xiaodong
肿瘤
OTUD4
肿瘤免疫
信号转导
YAP
胰腺癌
Hippo
发表日期：2026
文献求助 收藏

OTUD4 Inhibits Prostate Cancer by Deubiquitinating MYH9

OTUD4 通过去泛素化 MYH9 抑制前列腺癌

期刊:Oncology Research
影响因子:4.1
doi:10.32604/or.2025.073455
Qin, Zheng; Zhang, Yueyao; Liu, Dongze; Zheng, Xiaokang; Wang, Kaibin; Zhu, Xiao; Zhang, Yuanhao; Xu, Kexin; Li, Changying; Kang, Lijuan; Wang, Lili; Wang, Haitao
肿瘤
表观遗传
OTUD4
肿瘤免疫
泛素化
MYH
前列腺癌
发表日期：2026
文献求助 收藏

The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-κB signaling and inflammation

去泛素化酶OTUD4抑制TAK1激酶依赖的NF-κB信号通路和炎症反应。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110784
Liu, Zhaohui; Wang, Xiaolong; Wu, Lihui; Min, Li; Sheng, Ying; Sun, Zhiming; Deng, Yunfang; Miao, Lin; Liu, Yue; Li, Jiabing; Zhao, Yu
炎症
表观遗传
OTUD4
炎症/感染
信号转导
泛素化
NF-κB
发表日期：2025
文献求助 收藏

WSB1 promotes prostate cancer malignancy through OTUD4-mediated ISOC2 stabilization and P16INK4a suppression

WSB1通过OTUD4介导的ISOC2稳定和P16INK4a抑制促进前列腺癌恶性进展

期刊:American Journal of Cancer Research
影响因子:2.9
doi:10.62347/HGMA4543
Sun, Jian; Wang, Fei; Feng, Yuxuan; Qiu, Xiya; Qu, Wenying; He, Xuefeng; Xie, Jianjun; Li, Gang
肿瘤
前列腺癌
肿瘤免疫
OTUD4
发表日期：2025
文献求助 收藏

OTUD4 suppresses colorectal cancer progression through deubiquitinating p53

OTUD4 通过去泛素化 p53 抑制结直肠癌进展

期刊:Discover Oncology
影响因子:2.9
doi:10.1007/s12672-025-04033-6
Bu, Xianyue; Wang, Yingxu; Pan, Jinzhen; Li, Shuai; Li, Penghao; Zheng, Bing
肿瘤
肠癌
表观遗传
OTUD4
肿瘤免疫
泛素化
发表日期：2025
文献求助 收藏

Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers

通过药物抑制OTUD4/CD73蛋白水解轴可恢复针对免疫抑制性乳腺癌的抗肿瘤免疫力

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI176390
Zhu, Yueming; Banerjee, Anupam; Xie, Ping; Ivanov, Andrey A; Uddin, Amad; Jiao, Qiao; Chi, Junlong Jack; Zeng, Lidan; Lee, Ji Young; Xue, Yifan; Lu, Xinghua; Cristofanilli, Massimo; Gradishar, William J; Henry, Curtis J; Gillespie, Theresa W; Bhave, Manali Ajay; Kalinsky, Kevin; Fu, Haian; Bahar, Ivet; Zhang, Bin; Wan, Yong
CD7
肿瘤
OTUD4
肿瘤免疫
CD73
乳腺癌
免疫/内分泌
发表日期：2024
文献求助 收藏

CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation

CSE 通过 PAI-1 降解降低 OTUD4 引发肺上皮细胞凋亡

期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/s41419-023-06131-1
Lijuan Luo, Tiao Li, Zihang Zeng, Herui Li, Xue He, Yan Chen
信号转导
细胞生物学
上皮细胞
IP
WB
Apoptosis
Human
OTUD4
发表日期：2023
文献求助 收藏

The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection

去泛素化酶OTUD4抑制潘氏细胞抗菌肽表达，引发肠道炎症和细菌感染

期刊:Cell Insight
影响因子:
doi:10.1016/j.cellin.2023.100100
Keying Yu, Yu-Yao Guo, Tianzi Liuyu, Peng Wang, Zhi-Dong Zhang, Dandan Lin, Bo Zhong
免疫
微生物学
肠炎
其它细胞
IP
WB
OTUD4
发表日期：2023
文献求助 收藏