PARG相关文献与解析，生知库 | 链接生命科学的每一步

Cetnarowska, Anna; Hyldahl, Mette; Nygård, Marcus; Dashti, Hesam; Hansen, Bo Vagner; Holm, Laura Kristine; Madsen, Kaja; Madsen, Maria Stahl; Shukla, Vallari; Durmaz Mitchell, Esra; Rauch, Alexander; Madsen, Jesper Grud Skat; Claussnitzer, Melina; Mandrup, Susanne

PPARG

PARG

发表日期：2026

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Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration

TRIM25 水平升高通过 PARG 降解损害聚（ADP-核糖）代谢，并介导压迫引起的椎间盘退变。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202519248

Cheng, Zhangrong; Gao, Haiyang; Wu, Wenbo; Shi, Pengzhi; Chen, Xianglong; Yu, Zimu; Wu, Wang; Zhao, Kangcheng; Yang, Cao; Zhang, Yukun

CRISPR-Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function after myocardial infarction.

基于 CRISPR-Cas 的 PPARGC1A 激活可增强内源性线粒体功能，并在心肌梗死后改善心脏功能。

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2026.02.027

Escobar Mario, Malik Saad A, Srinivasa Mira A, Mendez-Sosa Miguel A, Miller Jessica M, Lydon Samantha L, Luong Sandy N, Mathew Pretty R, Abouleisa Riham R E, Chakravarty Suridh, Pathan Saliha, Mohamed Tamer M A, Ghanta Ravi K, Hilton Isaac B

Chromatin regulators TOP2A and PPARGC1A stratify prostate cancer risk and reveal TOP2A-driven progression via PI3K/AKT pathway

染色质调节因子TOP2A和PPARGC1A可对前列腺癌风险进行分层，并揭示TOP2A通过PI3K/AKT通路驱动的肿瘤进展。

期刊:Chinese Journal of Cancer Research

影响因子:6.3

doi:10.21147/j.issn.1000-9604.2026.01.06

Wang, Zhipeng; Wang, Jie; Chen, Shuang; Wu, Ruicheng; Tuo, Zhouting; Ye, Luxia; Yoo, Koo Han; Li, Dengxiong; Jin, Xiaodong; Xiong, Wei; Feng, Dechao

New PPARG Exons: Cell-Specific Expression of Their RNAs in the Human Placenta

新的PPARG外显子：其RNA在人胎盘中的细胞特异性表达

期刊:Cells

影响因子:5.2

doi:10.3390/cells15070639

Vignaud, Marie-Léone; Morin, Nathalie; Fournier, Thierry

Ellagic Acid Prevents Obesity in High-Fat Diet-Fed Rats by Ameliorating Oxidative Stress via Modulation of the PPARG/STAT3/p-AKT1 Axis.

鞣花酸通过调节 PPARG/STAT3/p-AKT1 轴来改善氧化应激，从而预防高脂饮食喂养大鼠的肥胖。

期刊:Foods

影响因子:5.1

doi:10.3390/foods15050890

Zheng Yuancui, Yuan Qin, Hu Shiyao, Wang Huiqun

A Novel PPARG R212W Variant Causes Familial Partial Lipodystrophy Type 3: Clinical Presentation and Functional Characterization

一种新型 PPARG R212W 变异导致家族性部分脂肪营养不良 3 型：临床表现和功能特征

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms27041851

Gao, Yuan; Song, Ningyi; Fu, Lina; Liang, Yan; Luo, Xiaoping

PPARG as a central regulator of ferroptosis in Alzheimer's disease: integrated transcriptomic, single-cell, and experimental evidence

PPARG作为阿尔茨海默病中铁死亡的核心调控因子：整合转录组学、单细胞和实验证据

期刊:Frontiers in Aging Neuroscience

影响因子:4.5

doi:10.3389/fnagi.2026.1759279

Tang, Lingjia; Wu, Ningning; Xu, Hong; Mo, Yuxuan

High-Grade Acinic Cell Carcinoma of the Parotid with SYN2::PPARG Fusion

腮腺高级别腺泡细胞癌伴SYN2::PPARG融合

期刊:Head & Neck Pathology

影响因子:4.1

doi:10.1007/s12105-026-01912-4

Puzyrenko, Andrii; Argyris, Prokopios P; Pasternak-Wise, Olga; Cipriani, Nicole A; Trzcinska, Anna M

Synergistic Cellular Toxicity from Inhibition of Poly(ADP-ribose) Glycohydrolase (PARG) and Ubiquitin-Specific Protease 1 (USP1)

抑制聚（ADP-核糖）糖苷水解酶（PARG）和泛素特异性蛋白酶1（USP1）的协同细胞毒性

期刊:Toxics

影响因子:4.1

doi:10.3390/toxics14020162

Leonard, Stefan M; Pearson, Charlotte R; Roos, Wynand P; Sobol, Robert W

Extensive enhancer crosstalk controls PPARG2 activation during adipogenesis

广泛的增强子串扰控制着脂肪生成过程中 PPARG2 的激活。

Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration

TRIM25 水平升高通过 PARG 降解损害聚（ADP-核糖）代谢，并介导压迫引起的椎间盘退变。

CRISPR-Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function after myocardial infarction.

基于 CRISPR-Cas 的 PPARGC1A 激活可增强内源性线粒体功能，并在心肌梗死后改善心脏功能。

Chromatin regulators TOP2A and PPARGC1A stratify prostate cancer risk and reveal TOP2A-driven progression via PI3K/AKT pathway

染色质调节因子TOP2A和PPARGC1A可对前列腺癌风险进行分层，并揭示TOP2A通过PI3K/AKT通路驱动的肿瘤进展。

New PPARG Exons: Cell-Specific Expression of Their RNAs in the Human Placenta

新的PPARG外显子：其RNA在人胎盘中的细胞特异性表达

Ellagic Acid Prevents Obesity in High-Fat Diet-Fed Rats by Ameliorating Oxidative Stress via Modulation of the PPARG/STAT3/p-AKT1 Axis.

鞣花酸通过调节 PPARG/STAT3/p-AKT1 轴来改善氧化应激，从而预防高脂饮食喂养大鼠的肥胖。

A Novel PPARG R212W Variant Causes Familial Partial Lipodystrophy Type 3: Clinical Presentation and Functional Characterization

一种新型 PPARG R212W 变异导致家族性部分脂肪营养不良 3 型：临床表现和功能特征

PPARG as a central regulator of ferroptosis in Alzheimer's disease: integrated transcriptomic, single-cell, and experimental evidence

PPARG作为阿尔茨海默病中铁死亡的核心调控因子：整合转录组学、单细胞和实验证据

High-Grade Acinic Cell Carcinoma of the Parotid with SYN2::PPARG Fusion

腮腺高级别腺泡细胞癌伴SYN2::PPARG融合

Synergistic Cellular Toxicity from Inhibition of Poly(ADP-ribose) Glycohydrolase (PARG) and Ubiquitin-Specific Protease 1 (USP1)

抑制聚（ADP-核糖）糖苷水解酶（PARG）和泛素特异性蛋白酶1（USP1）的协同细胞毒性