日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition.

小叶乳腺癌中 MDC1 相互作用的改变和 DNA 修复功能障碍赋予了其对 PARP 抑制剂的敏感性。

Sottnik Joseph L, Shackleford Madeleine T, Nesiba Camryn S, Richer Amanda L, Fleischmann Zoe, Swartz Jordan M, Rowland Carmen E, Musick Maggie, Fu Rui, Myler Logan R, Opresko Patricia L, Mehrotra Sanjana, Sokol Ethan S, Hesselberth Jay R, Diamond Jennifer R, Sikora Matthew J

Author Correction: Combination of PARP and KRAS(G12D) inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC

作者更正:PARP 和 KRAS(G12D) 抑制剂联合应用可通过利用 PDAC 的弱点来增强治疗效果。

Xu, Xin; Chen, Xin; Xu, Rongli; Huo, Zhenyu; Li, Changying; Nowsheen, Somaira; Aziz, Khaled; Yao, Fan; Lou, Zhenkun; Deng, Min

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation

PARP1-HPF1 在缺口 DNA 上的结构和动力学揭示了一种急性局部 ADP 核糖基化的机制

Sverzhinsky, Aleksandr; Xue, Huijun; Langelier, Marie-France; Muniz Corrêa, Marcelo V; Del Mundo, Joshua; Classen, Scott; Hammel, Michal; Rothenberg, Eli; Pascal, John M

Combination of PARP and KRAS(G12D) inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC.

PARP 和 KRAS(G12D) 抑制剂的联合应用,利用 PDAC 的弱点,增强了治疗效果。

Xu Xin, Chen Xin, Xu Rongli, Huo Zhenyu, Li Changying, Nowsheen Somaira, Aziz Khaled, Yao Fan, Lou Zhenkun, Deng Min

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas.

L-天冬酰胺酶诱导的肿瘤代谢适应揭示了B细胞淋巴瘤对PARP1/2抑制剂的脆弱性。

Aussel Anaïs, Nemazanyy Ivan, Vandenberghe Ashaina, Meola Pauline, Dorat Noémie, Paul Rachel, Habbouche Lama, Exposito Laurie, Nottet Nicolas, Petrilli Virginie, Chiche Edmond, Mounier Nicolas, Marchetti Sandrine, Chaveroux Cédric, Ricci Jean-Ehrland, Chiche Johanna

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling.

对单(ADP-核糖基)化和多(ADP-核糖基)化的多功能和灵敏检测揭示了 XRCC1 依赖的 PARP1 信号重塑。

Dauben Helen, Mihaljević Mihaela, Kolvenbach Andreas, Palumbieri Maria Dilia, Kapsali Chrysi, Huppertz Ina, Matić Ivan

Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer.

靶向从头嘧啶合成会使 PARP 抑制剂耐药的卵巢癌对铜介导的 ATR 失活变得脆弱。

Nan Yabing, Wang Kunyu, Hu Menghan, Luo Qingyu, Wu Xiaowei, Yu Xiao, Zhou Xuantong, Chen Li, Li Bin, Cui Zhumei, Liu Zhihua

Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging

唾液乳杆菌衍生的吲哚-3-乙酸促进AHR-PARP1轴介导的DNA修复,从而延缓肠道衰老

Cao, Zheng; Zhang, Cui; Lei, Hehua; Lin, Weichuan; Yu, Wenkai; Gao, Xin; He, Yanmeng; Li, Xinzhi; Xiang, Qingwei; Zhang, Zhiwen; Luo, Weifei; Patterson, Andrew D; Zhang, Limin; Chen, Gang

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites.

PARPi 结合纳米颗粒 LIN28B siRNA 用于治疗恶性腹水。

Fang Yan, Shen Qian, Lin Yao, Zhu Jing, Zhu Xiaolan, Huang Rui, Wu Yijia, Shen Feiyang, Li Qian, Zheng Guopei, Zhang Zhe, Chu Qian, Hu Junhao, Shen Jianfeng

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant Glioma.

Prickle4 驱动 IDH 突变型胶质瘤的微环境重塑和对 Parp 抑制剂的耐药性。

Yang Ju, Yang Hua, Yuan Yifan, Zhang Chenyang, Fu Ziwei, Chen Yanyan, Xiong Yinghong, Chen Shuyu, Ling Kexin, Liu Ying, Huse Jason T, Chen Bo, Chan Timothy A, Qi Zengxin, Zhang Zhao, Liu Xiuping, Wang Yuxiang