日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Efficacy and Safety of Oral PCSK9 Inhibitor Enlicitide in Adults With Heterozygous Familial Hypercholesterolemia: A Randomized Clinical Trial

口服PCSK9抑制剂恩利西肽治疗杂合子家族性高胆固醇血症成人患者的疗效和安全性：一项随机临床试验

期刊:Journal of the American Medical Association
影响因子:55
doi:10.1001/jama.2025.20620
Ballantyne, Christie M; Gellis, Laura; Tardif, Jean-Claude; Banka, Puja; Navar, Ann Marie; Asprusten, Emil Andreas; Scott, Russell; Stroes, Erik S G; Froman, Samar; Mendizabal, Geraldine; Wang, Fan; Catapano, Alberico L
PCSK9
CSK
代谢
发表日期：2026
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Response to PCSK9 Inhibition Based on LDL Receptor Function in Familial Hypercholesterolemia: A Nonrandomized Clinical Trial

基于LDL受体功能的PCSK9抑制剂治疗家族性高胆固醇血症的疗效：一项非随机临床试验

期刊:Jama Cardiology
影响因子:14.1
doi:10.1001/jamacardio.2026.0879
Raal, Frederick J; Fourie, Nyda; Scott, Russell; Blom, Dirk J; Basson, Matthys M De Vries; Kayikcioglu, Meral; Roth, Mendel; Vest, Jeffrey; Kallend, David; Stein, Evan A
PCSK9
信号转导
CSK
代谢
发表日期：2026
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Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8(+) T cell immunity via rewiring MHC-I antigen presentation

经基因工程改造的溶瘤病毒携带抗PCSK9 scFv，可通过重塑MHC-I抗原呈递途径增强长期CD8(+) T细胞免疫力

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2026.102724
Feng, Huolun; Zhang, Yuhan; Huang, Zuda; Zhou, Jianlong; Liu, Yongfeng; Xiao, Xiao; Chen, Mingxi; Guo, Xin; Zheng, Jiabin; Lyu, Zejian; Hu, Weixian; Wu, Deqing; Li, Yong; Xing, Fan
微生物学
CSK
CD8
免疫/内分泌
细胞生物学
T细胞
PCSK9
T细胞
发表日期：2026
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Therapeutic Potential of PCSK9 Inhibitors in Regulating Neuroinflammation in Acute Ischemic Stroke

PCSK9抑制剂在调节急性缺血性卒中神经炎症中的治疗潜力

期刊:CNS Drugs
影响因子:7.4
doi:10.1007/s40263-026-01278-9
Pu, Lanlan; Liu, Jiahui; Kong, Shuying; Joyama, Yuki; Gong, Xing; Ji, Xiaofei; Dong, Huijie
炎症
炎症/感染
神经科学
CSK
神经炎症
PCSK9
发表日期：2026
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Integrative Proteomic and Lipidomic Analysis of Patients With Acute Myocardial Infarction Treated With PCSK9 Antibodies and Statins

对接受PCSK9抗体和他汀类药物治疗的急性心肌梗死患者进行整合蛋白质组学和脂质组学分析

期刊:Circulation-Genomic and Precision Medicine
影响因子:5.5
doi:10.1161/CIRCGEN.125.005345
Schmidt, Lukas E; Burnap, Sean A; Singh, Bhawana; Takov, Kaloyan; Losdat, Sylvain; Schrutka, Lore; Galli, Lukas; Theofilatos, Konstantinos; Otto, Georg W; Hengstenberg, Christian; Tzoulaki, Ioanna; Lang, Irene M; Koskinas, Konstantinos C; Speidl, Walter S; Räber, Lorenz; Mayr, Manuel
CSK
心肌梗塞
PCSK9
心血管
发表日期：2026
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PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience

PCSK9表达与癌症生存：肿瘤学与老年科学交叉领域的预后生物标志物

期刊:Geroscience
影响因子:5.4
doi:10.1007/s11357-025-01733-3
Ungvari, Zoltan; Menyhart, Otília; Lehoczki, Andrea; Fekete, Monika; Bianchini, Giampaolo; Győrffy, Balázs
CSK
肿瘤
PCSK9
肿瘤免疫
发表日期：2026
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Identification of a peptide inhibitor disrupting the PCSK9-LDLR interaction via pharmacophore-based virtual screening, molecular dynamics simulations and in vitro/vivo evaluation.

通过基于药效团的虚拟筛选、分子动力学模拟和体外/体内评价，鉴定出一种能够破坏 PCSK9-LDLR 相互作用的肽抑制剂。

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2610849
Wu Wanling, Yang Shudan, Liu Jie, Wang Yuting, Pan Defeng, Zhou Yafeng
CSK
LDLR
PCSK9
发表日期：2026
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PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway

PCSK9抑制剂阿利西尤单抗通过ERK/p38 MAPK信号通路改善糖尿病心肌病

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms27052341
Lin, Shan; Wu, Bangwei; Sun, Shengjia; Sun, Tao
心肌病
信号转导
心血管
代谢
MAPK/ERK
CSK
糖尿病
PCSK9
发表日期：2026
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Alirocumab Attenuated Plaque Inflammation and PCSK9-Induced Proinflammatory Signalling in M1 Macrophages Independently of Lipid Lowering.

Alirocumab 可减轻 M1 巨噬细胞中的斑块炎症和 PCSK9 诱导的促炎信号传导，且与降低血脂无关。

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom16030397
Espadas Cristina, Soto-Catalán Manuel, Romero-Cote María, Kavanagh María, Herrero-Del Real Isabel, Ortega-Hernández Adriana, Lumpuy-Castillo Jairo, Gómez-Garre Dulcenombre, Egido Jesús, Tuñón José, Gómez-Guerrero Carmen, Lorenzo Óscar
细胞生物学
巨噬细胞
CSK
PCSK9
Immunology/Inflammation
炎症
巨噬细胞
发表日期：2026
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Refined Design and Liquid-Phase Assembly of GalNAc-siRNA Conjugates: Comparative Efficiency Validation in PCSK9 Targeting

GalNAc-siRNA缀合物的精细设计和液相组装：在PCSK9靶向治疗中的效率比较验证

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules31030476
Dmitriev, Nikolai A; Chernov, Petr V; Gongadze, Ivan S; Kovchina, Valeriia I; Ivanov, Vladimir N; Gusev, Artem E; Shilovskiy, Igor P; Kofiadi, Ilya A; Khaitov, Musa R
CSK
PCSK9
发表日期：2026
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