日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanding the therapeutic landscape of PDE10A inhibition through alchemical absolute binding free energy calculations and in-vitro evaluation

通过炼金术绝对结合自由能计算和体外评价,拓展PDE10A抑制剂的治疗领域

Sharma, Bhanu; Singh, Rahul; Kumar, Ashish; Das, Pralay; Purohit, Rituraj

Phase 2b Trial of the PDE10A Inhibitor MK-8189 in People With an Acute Episode of Schizophrenia

PDE10A抑制剂MK-8189治疗急性精神分裂症患者的2b期试验

Mukai, Yuki; Kost, James; Snow-Adami, Linda; Reed, Jessica; Taylor, Theresa; Kent, Justine; Egan, Michael F

ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

ADT-030 是一种新型 PDE10 抑制剂,在胰腺导管腺癌中表现出强大的抗肿瘤活性。

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Foote, Jeremy B; Keeton, Adam B; Chen, Xi; Ramirez-Alcantara, Veronica; Holmes, Thomas; Akce, Mehmet; Singh, Anju; Powell, Craig M; Behera, Santosh; Azmi, Asfar S; Nurmemmedov, Elmar; Babic, Ivan; Gorman, Gregory S; Coward, Lori; Buchsbaum, Donald J; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise

PDE1B 和 PDE10A 作为精神分裂症的新靶点:从分子设计与合成到治疗前景

Rautela, Jaya; Gaurav, Anand; Nissapatorn, Veeranoot; Tan, Chung Keat; Girol, Ana Paula; Pereira, Maria De Lourdes; Lee, Vannajan Sanghiran

PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges

PDE10A作为癌症诊断和治疗的新型靶点:见解与挑战

Ghoflchi, Sahar; Nakhaei, Ali; Abbasinezhad-Moud, Farzaneh; Jalili-Nik, Mohammad; Cimino, Patrick J

A Novel PDE10A Inhibitor for Tourette Syndrome and Other Movement Disorders

一种用于治疗图雷特综合症和其他运动障碍的新型 PDE10A 抑制剂

Randall D Marshall, Frank S Menniti, Mark A Tepper

THPP-1 PDE10A inhibitor reverses the cognitive deficits and hyperdopaminergic state in a neurodevelopment model of schizophrenia

THPP-1 PDE10A抑制剂可逆转精神分裂症神经发育模型中的认知缺陷和多巴胺能亢进状态

Uliana, Daniela L; Martinez, Angela; Grace, Anthony A

PDE10A Inactivation Prevents Doxorubicin-Induced Cardiotoxicity and Tumor Growth

PDE10A失活可预防阿霉素诱导的心脏毒性和肿瘤生长

Chen, Si; Chen, Jiawei; Du, Wenting; Mickelsen, Deanne M; Shi, Hangchuan; Yu, Han; Kumar, Sparsh; Yan, Chen

Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling

PDE10A 在血管平滑肌细胞增生和病理性血管重塑中的作用

Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia G Hsu, Vyacheslav A Korshunov, Xiaochun Long, Peter A Knight, Bradford C Berk, Chen Yan

Phosphodiesterase 10A (PDE10A): Regulator of Dopamine Agonist-Induced Gene Expression in the Striatum

磷酸二酯酶10A (PDE10A):纹状体中多巴胺激动剂诱导基因表达的调节因子

Bonate, Ryan; Kurek, Gabriela; Hrabak, Michael; Patterson, Santanna; Padovan-Neto, Fernando; West, Anthony R; Steiner, Heinz