PDX1相关文献与解析，生知库 | 链接生命科学的每一步

Benjamin J Weidemann ，Biliana Marcheva ，Mikoto Kobayashi ，Chiaki Omura ，Marsha V Newman ，Yumiko Kobayashi ，Nathan J Waldeck ，Mark Perelis ，Louise Lantier ，Owen P McGuinness ，Kathryn Moynihan Ramsey ，Roland W Stein ，Joseph Bass

信号转导

NF-κB

细胞生物学

发表日期：2024

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Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice

造血细胞中 Pdx1 的表达激活 Kras 突变，从而驱动 KC (Pdx1-Cre; LSL-KrasG12D/+) 小鼠发生白血病。

期刊:Leukemia & Lymphoma

影响因子:2.2

doi:10.1080/10428194.2023.2202788.

Morgan T Walcheck ,Manabu Nukaya ,Erik A Ranheim ,Kristina A Matkowskyj ,Sean Ronnekleiv-Kelly

The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function

NuRD复合物的Chd4亚基调节Pdx1控制的、参与β细胞功能的基因。

期刊:Journal of Molecular Endocrinology

影响因子:3.6

doi:10.1530/JME-22-0011

Rebecca K Davidson ,Staci A Weaver ,Nolan Casey ,Sukrati Kanojia ,Elise Hogarth ,Rebecca Schneider Aguirre ,Emily K Sims ,Carmella Evans-Molina ,Jason M Spaeth

细胞生物学

发表日期：2022

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Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

柯萨奇病毒B型4型感染β细胞通过Pdx1沉默下调分子伴侣Prefoldin URI，从而诱导MODY4样糖尿病

期刊:Cell Reports Medicine

影响因子:11.7

doi:10.1016/j.xcrm.2020.100125

Hugo Bernard ，Ana Teijeiro ，Almudena Chaves-Pérez ，Cristian Perna ，Basanthi Satish ，Anna Novials ，Jennifer P Wang ，Nabil Djouder

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

PDX1转录激活结构域的点突变会损害人类β细胞的发育和功能。

期刊:Molecular Metabolism

影响因子:7

doi:10.1016/j.molmet.2019.03.006

Xianming Wang ,Michael Sterr ,Ansarullah ,Ingo Burtscher ,Anika Böttcher ,Julia Beckenbauer ,Johanna Siehler ,Thomas Meitinger ,Hans-Ulrich Häring ,Harald Staiger ,Filippo M Cernilogar ,Gunnar Schotta ,Martin Irmler ,Johannes Beckers ,Christopher V E Wright ,Mostafa Bakhti ,Heiko Lickert

Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays

利用微加工的细胞排斥微孔阵列从分离的人类诱导性多能干细胞形成明确的胚状体

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/srep07402

Giuseppe Pettinato, Xuejun Wen, Ning Zhang

Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity

PDX1对潜在NF-κB增强子的抑制作用调控β细胞功能异质性

Pdx1 expression in hematopoietic cells activates Kras-mutation to drive leukemia in KC (Pdx1-Cre; LSL-KrasG12D/+) mice

造血细胞中 Pdx1 的表达激活 Kras 突变，从而驱动 KC (Pdx1-Cre; LSL-KrasG12D/+) 小鼠发生白血病。

The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function

NuRD复合物的Chd4亚基调节Pdx1控制的、参与β细胞功能的基因。

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

柯萨奇病毒B型4型感染β细胞通过Pdx1沉默下调分子伴侣Prefoldin URI，从而诱导MODY4样糖尿病

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

PDX1转录激活结构域的点突变会损害人类β细胞的发育和功能。

Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays

利用微加工的细胞排斥微孔阵列从分离的人类诱导性多能干细胞形成明确的胚状体